Fig. 1

Body weight (a), reactive oxygen species (ROS) and lipid peroxidation (LPO) analyses (b), and representative photomicrographs of hematoxylin and eosin staining (c-f) in the cerebral cortices of control and lipopolysaccharide (LPS)-treated animals. LPS induced a reduction of body weight (a) and increases of DCF and MDA values (b). LPS treatment induced severe histopathological changes including swelling and vacuolation of nerve cells (d and f). Arrows indicate normal pyramidal cells with well-characterized dendrites (e). Open arrows indicate abnormal nerve cells that were swollen and vacuolated (f). Arrowheads indicate shrunken neuroglial cells (f). Magnified photos indicate square region. Scale bar = 100 μm (c and d), 200 μm (e and f). Data (n = 5) are shown as mean ± S.E.M. ^# p < 0.05 vs. control animal