Skip to main content


Fig. 5 | Laboratory Animal Research

Fig. 5

From: Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus

Fig. 5

Immunohistochemistry for pCREB in the dentate gyrus of control (a), vehicle- (b), control-HSP70- (c), and Tat-HSP70-treated (d) mice. In all groups, pCREB-positive nuclei (arrows) are mainly observed in the subgranular zone of the dentate gyrus. Note that pCREB-positive nuclei are strongly observed in the dentate gyrus of Tat-HSP70-treated mice. GCL, granule cell layer; ML, molecular layer; PL, polymorphic layer. Scale bar = 50 μm. e The number of pCREB-positive nuclei per section for each group are shown and f values from western blot analysis is expressed as a ratio of pCREB and CREB immunoblot band in control group (n = 5 per group; aP < 0.05, versus control group; bP < 0.05, versus vehicle-treated group). Data are presented as mean ± SEMs

Back to article page