Fig. 1
From: Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus
a-l p53 immunohistochemistry in the hippocampus of the young (a, d, g, j), adult (b, e, h, k) and aged (c, f, i, l) mice. p53 immunoreactivity is shown in the pyramidal cells (arrows) and granule cells (asterisk) in the young mouse hippocampus. p53 immunoreactivity in these cells is significantly and gradually decreased during aging process. GCL, granule cell layer; ML, molecular layer; PL, polymorphic layer; SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum. Scale bar = 400 μm (A-C) and 100 μm (D-L). (M) ROD as % of p53 immunoreactive cells in the hippocampus (n = 7 per group; *P < 0.05, significantly different from the young group, †P < 0.05, significantly different from the adult group). The bars indicate the means ± SEM