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Fig. 2 | Laboratory Animal Research

Fig. 2

From: Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus

Fig. 2

A-L p63 immunohistochemistry in the hippocampus of the young (a, d, g, j), adult (b, e, h, k) and aged (c, f, i, l) mice. p63 immunoreactivity is found in pyramidal cells (arrows) and granule cells (asterisk) in the young mouse hippocampus. p63 immunoreactivity is gradually reduced during aging, showing that p63 immunoreactivity is hardly shown in aged granule cells (arrowhead). GCL, granule cell layer; ML, molecular layer; PL, polymorphic layer; SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum. Scale bar = 400 μm (A-C and a-c) and 100 μm (D-L and d-l). (M) Relative optical density (ROD) as % of p63 immunoreactive cells in the hippocampus (n = 7 per group; *P < 0.05, significantly different from the young group, P < 0.05, significantly different from the adult group). The bars indicate the means ± SEM

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