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Fig. 3 | Laboratory Animal Research

Fig. 3

From: Characterization and applications of chimeric mice with humanized livers for preclinical drug development

Fig. 3

Histological findings in PXB-mouse livers. a H&E staining of left lateral lobes. Area within rectangle is magnified in (b). Human hepatocytes with clear cytoplasm and lipid droplets occupied most areas of the liver section. b Mouse hepatocytes with eosinophilic cytoplasm of various sizes are shown by arrows. c The left lateral lobe of PXB-mouse was immunostained with anti-hCK8/18 antibodies. Human hepatocytes were brown-colored, and the area within the rectangle is magnified in (d). d m, mouse hepatocytes, h, human hepatocytes. H&E staining of 14 weeks. Bar = 100 μm

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