Table 1 Publications using humanized mouse/cells
Chimeric mice or cells | PXB-mouse | FRG mouse | TK-NOG mouse | uPA/SCID mouse (CA)a | uPA/SCID mouse (DE)b | uPA/SCID mouse (BE)c | uPA/SCID mouse (FR)d | PXB-cells | Total |
|---|---|---|---|---|---|---|---|---|---|
Anti-HBV agents | |||||||||
 Nucleic acid analog | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 5 |
 Small molecule | 7 | 1 | 0 | 0 | 0 | 0 | 0 | 10 | 18 |
 Interferon | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 6 |
 siRNA/miRNA | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 6 |
 Antibody | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
 Others | 0 | 1 | 0 | 0 | 6 | 0 | 0 | 0 | 7 |
Ant-HCV agents | |||||||||
 Small molecule | 24 | 3 | 2 | 3 | 0 | 4 | 1 | 0 | 37 |
 Interferon | 5 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 8 |
 Small molecule +Interferon | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5 |
 siRNA | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
 Antibody | 3 | 3 | 0 | 3 | 1 | 9 | 0 | 0 | 19 |
 Others | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
DMPK/Toxicology | |||||||||
 ADME | 24 | 3 | 11 | 0 | 0 | 10 | 0 | 2 | 50 |
 DDI | 5 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 9 |
 Liver toxicity | 19 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 24 |
Total | 105 | 14 | 23 | 8 | 13 | 23 | 1 | 16 | 203 |