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Table 1 HBx transgenic mice published

From: Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

HBV DNA subtype Promoter Mouse strain Tumor generation Published paper
adr HBV X CD-1 HCC Kim et al. (Nature 1991) [28]
adr HBV X F1 hybrid (C57BL/6 X DBA) HCC Yu et al. (J of Hepatology 1999) [33]
ayw SV40, ATIII, HBV X F1 hybrid (C57BL/6 X DBA) No serious liver damage BILLET et al. (J of Virology 1995) [29]
adw Alpha1 antitrypsin ICR females X B6C3F1 males. No tumor Lee et al. (J of Virology 1990)
ayw HBV X F1 hybrid (C57BL/6 X DBA) No description Perfumo et al. (J of Virology 1992) [31]
No description HBV X, Rat insulin II C57BL/6, F2 hybrid(C57BL/6 X DBA) No pathological change Reifenberg et al. (J of Hepatology 1997) [32]
ayw albumin C57BL/6 HCC Wu et al. (BBRC 2006) [34]
No description HBV X in p21 locus C57BL/6 HCC Wang et al. (Hepatology 2004) [35]