Table 1 HBx transgenic mice published
HBV DNA subtype | Promoter | Mouse strain | Tumor generation | Published paper |
|---|---|---|---|---|
adr | HBV X | CD-1 | HCC | Kim et al. (Nature 1991) [28] |
adr | HBV X | F1 hybrid (C57BL/6 X DBA) | HCC | Yu et al. (J of Hepatology 1999) [33] |
ayw | SV40, ATIII, HBV X | F1 hybrid (C57BL/6 X DBA) | No serious liver damage | BILLET et al. (J of Virology 1995) [29] |
adw | Alpha1 antitrypsin | ICR females X B6C3F1 males. | No tumor | Lee et al. (J of Virology 1990) |
ayw | HBV X | F1 hybrid (C57BL/6 X DBA) | No description | Perfumo et al. (J of Virology 1992) [31] |
No description | HBV X, Rat insulin II | C57BL/6, F2 hybrid(C57BL/6 X DBA) | No pathological change | Reifenberg et al. (J of Hepatology 1997) [32] |
ayw | albumin | C57BL/6 | HCC | Wu et al. (BBRC 2006) [34] |
No description | HBV X in p21 locus | C57BL/6 | HCC | Wang et al. (Hepatology 2004) [35] |