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Table 3 The histological phenotype in the liver of wild and HBx-Tg hybrid mice

From: Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

  Group 1 Group 2 Group 3
WT HBx Tg P-value WT HBx Tg P-value WT HBx Tg P-value
Micro-fatty change 0/34(0%) 15/47 (31.9%) 0.001 1/6 (16.7%) 12/14 (85.7%) 0.003 5/9 (55.6%) 8/8 (100%) 0.031
Macro-fatty change 0/34(0%) 2/47 (4.3%) 0.223 0/6 (0%) 4/14 (28.6%) 0.143 0/9 (0%) 8/8 (100%) 0.000
Inflammation 0/34(0%) 8/47 (17.0%) 0.011 0/6 (0%) 1/14 (7.1%) 0.502 0/9 (0%) 1/8 (12.5%) 0.274
Necrosis 0/34(0%) 1/47 (2.2%) 0.392 0/6 (0%) 0/14 (0%) 0/9 (0%) 0/8 (0%)
Dysplasia 0/34(0%) 46/47 (97.9%) 0.000 0/6 (0%) 13/14 (92.9%) 0.000 0/9 (0%) 8/8 (100%) 0.001
Dysplastic nodule 0/34(0%) 0/47 (0%) 0/6 (0%) 4/14 (28.6%) 0.143 0/9 (0%) 7/8 (87.5%) 0.000
Tumor 0/34(0%) 0/47 (0%) 0/6 (0%) 2/1414.3%) 0.329 0/9 (0%) 7/8 (87.5%) 0.000
  1. Group 1: ~ 12 weeks, Group 2: 12~28 weeks, Group 3: 28~36 weeks