Table 3 The histological phenotype in the liver of wild and HBx-Tg hybrid mice

From: Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

	Group 1			Group 2			Group 3
	WT	HBx Tg	P-value	WT	HBx Tg	P-value	WT	HBx Tg	P-value
Micro-fatty change	0/34(0%)	15/47 (31.9%)	0.001	1/6 (16.7%)	12/14 (85.7%)	0.003	5/9 (55.6%)	8/8 (100%)	0.031
Macro-fatty change	0/34(0%)	2/47 (4.3%)	0.223	0/6 (0%)	4/14 (28.6%)	0.143	0/9 (0%)	8/8 (100%)	0.000
Inflammation	0/34(0%)	8/47 (17.0%)	0.011	0/6 (0%)	1/14 (7.1%)	0.502	0/9 (0%)	1/8 (12.5%)	0.274
Necrosis	0/34(0%)	1/47 (2.2%)	0.392	0/6 (0%)	0/14 (0%)	–	0/9 (0%)	0/8 (0%)	–
Dysplasia	0/34(0%)	46/47 (97.9%)	0.000	0/6 (0%)	13/14 (92.9%)	0.000	0/9 (0%)	8/8 (100%)	0.001
Dysplastic nodule	0/34(0%)	0/47 (0%)	–	0/6 (0%)	4/14 (28.6%)	0.143	0/9 (0%)	7/8 (87.5%)	0.000
Tumor	0/34(0%)	0/47 (0%)	–	0/6 (0%)	2/1414.3%)	0.329	0/9 (0%)	7/8 (87.5%)	0.000

Group 1: ~ 12 weeks, Group 2: 12~28 weeks, Group 3: 28~36 weeks

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