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Table 3 The histological phenotype in the liver of wild and HBx-Tg hybrid mice

From: Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

 Group 1Group 2Group 3
WTHBx TgP-valueWTHBx TgP-valueWTHBx TgP-value
Micro-fatty change0/34(0%)15/47 (31.9%)0.0011/6 (16.7%)12/14 (85.7%)0.0035/9 (55.6%)8/8 (100%)0.031
Macro-fatty change0/34(0%)2/47 (4.3%)0.2230/6 (0%)4/14 (28.6%)0.1430/9 (0%)8/8 (100%)0.000
Inflammation0/34(0%)8/47 (17.0%)0.0110/6 (0%)1/14 (7.1%)0.5020/9 (0%)1/8 (12.5%)0.274
Necrosis0/34(0%)1/47 (2.2%)0.3920/6 (0%)0/14 (0%)0/9 (0%)0/8 (0%)
Dysplasia0/34(0%)46/47 (97.9%)0.0000/6 (0%)13/14 (92.9%)0.0000/9 (0%)8/8 (100%)0.001
Dysplastic nodule0/34(0%)0/47 (0%)0/6 (0%)4/14 (28.6%)0.1430/9 (0%)7/8 (87.5%)0.000
Tumor0/34(0%)0/47 (0%)0/6 (0%)2/1414.3%)0.3290/9 (0%)7/8 (87.5%)0.000
  1. Group 1: ~ 12 weeks, Group 2: 12~28 weeks, Group 3: 28~36 weeks