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Table 3 Large cohorts of PDX consortiums

From: Patient-derived xenografts as compatible models for precision oncology

  Organization Cancer types No. of models Genome data Distribution Web site
EurOPDX EuroPDX consortium
(16 academic institutions)
30 1924 Gene mutations Available (Trans-national access or collaboration) https://www.europdx.eu/
NCI Patient-Derived Models Repository (PDMR) National Cancer Institute, USA 65 2925 OncoKB cancer panel, whole exome sequencing, RNA sequencing Available https://pdmr.cancer.gov/
Public Repository of Xenografts (PRoXe) Weinstock Laboratory Leukemia, lymphoma 157 Targeted exome sequencing (205 gene), RNA sequencing Available https://www.proxe.org/
The Jackson Laboratory PDX cohort The Jackson Laboratory 35 400+ Targeted exome sequencing, whole exome sequencing, RNA sequencing Available https://www.jax.org/jax-mice-and-services/in-vivo-pharmacology/oncology-services/pdx-tumors
Novartis Institutes for Biomedical Research PDX Encyclopedia (NIBR PDXE) Norvatis 16 1075 Whole exome sequencing, SNP array, RNA sequencing Not available https://www.nature.com/articles/nm.3954