Table 3 Large cohorts of PDX consortiums
From: Patient-derived xenografts as compatible models for precision oncology
| Â | Organization | Cancer types | No. of models | Genome data | Distribution | Web site |
|---|---|---|---|---|---|---|
EurOPDX | EuroPDX consortium (16 academic institutions) | 30 | 1924 | Gene mutations | Available (Trans-national access or collaboration) | |
NCI Patient-Derived Models Repository (PDMR) | National Cancer Institute, USA | 65 | 2925 | OncoKB cancer panel, whole exome sequencing, RNA sequencing | Available | |
Public Repository of Xenografts (PRoXe) | Weinstock Laboratory | Leukemia, lymphoma | 157 | Targeted exome sequencing (205 gene), RNA sequencing | Available | |
The Jackson Laboratory PDX cohort | The Jackson Laboratory | 35 | 400+ | Targeted exome sequencing, whole exome sequencing, RNA sequencing | Available | https://www.jax.org/jax-mice-and-services/in-vivo-pharmacology/oncology-services/pdx-tumors |
Novartis Institutes for Biomedical Research PDX Encyclopedia (NIBR PDXE) | Norvatis | 16 | 1075 | Whole exome sequencing, SNP array, RNA sequencing | Not available |