Characterization of changes in global gene expression in the hearts and kidneys of transgenic mice overexpressing human angiotensin-converting enzyme 2

Table 3 Gene ontology and KEGG pathways related to human ACE2 overexpression in kidneys of dTg mice

P-value	KEGG pathway	Gene counts
2.12E-11	Oxidative phosphorylation	97
0.001377066	Valine, leucine and isoleucine degradation	35
0.006218532	Prostate cancer	78
0.009537098	One carbon pool by folate	17
0.017347632	Glycerolipid metabolism	34
0.018135441	Amyotrophic lateral sclerosis (ALS)	19
0.021784257	Basal cell carcinoma	41
0.023491979	DNA polymerase	23
0.026797164	1- and 2-Methylnaphthalene degradation	20
0.028321892	Ubiquinone biosynthesis	8
0.029679868	TGF-beta signaling pathway	67
0.032515198	Colorectal cancer	73
0.032849174	Wnt signaling pathway	110
0.038628325	Antigen processing and presentation	49
0.04013507	Apoptosis	65
0.045726832	Fatty acid metabolism	29
0.048242938	Pentose and glucuronate interconversions	13

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