Fig. 1

Experimental scheme and average tumor number in the three BALB/c substrains. a After applying single dose DMBA, three different doses of TPA were applied to the shaved back skin, twice weekly for 20 weeks. Also, one group of BALB/c mice was administered DMBA and medium dose TPA, with subsequent intraperitoneal injection of cisplatin as anti-tumor drug. b Average number of tumors. Only papilloma with tumor size 2 cm or more were counted, and are represented in the graph. Data represent the mean ± SD. *, p < 0.05 compared to the No treated group. #, p < 0.05 compared to the Vehicle treated group