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Table 1 Summary of simian varicella virus outbreak and follow-up

From: Intratracheal inoculation of human varicella zoster virus (VZV; MAV strain) vaccine successfully induced VZV IgG antibodies in rhesus monkeys

 

Symptoms

SVV viremia

(PCR)

Immune status during SVV outbreak

Treatment of SVV

Follow up

R1

Fever

Vesicular skin rash

Anorexia

Vomiting

+

Immunosuppression for islet TPL

Ganciclovir

Cefazolin

Ibuprofen

Adalimumab

Maropitant citrate

↑AST and ALT

Death 3 days after the onset of symptoms

R2

Fever

Vesicular skin rash

Anorexia

+

Immunosuppression for islet TPL

Ganciclovir

Cefazolin

Ibuprofen

Adalimumab

Disappearance of rash 5 days after the onset of symptoms

Recovery

R3

Fever

Vesicular skin rash

+

Immunocompetence

Ganciclovir IV SID

Cefazolin

Ibuprofen

Disappearance of rash 6 days after the onset of symptoms

Recovery

R4

Vesicular skin rash

Vomiting

+

Immunocompetence

Ganciclovir IV SID

Cefazolin

Maropitant citrate

Disappearance of rash 6 days after the onset of symptoms

Recovery

R5

+

Immunosuppression for islet TPL

Prophylactic use of ganciclovir

SVV viremia detected but no symptoms by prophylactic use of ganciclovir

R6

+

Immunocompetence

Prophylactic use of ganciclovir

SVV viremia detected but no symptoms by prophylactic use of ganciclovir

R7

Immunosuppression for islet TPL

Prophylactic use of ganciclovir

 

R8

Immunocompetence

Prophylactic use of ganciclovir

 

R9

Immunosuppression for islet TPL

Prophylactic use of ganciclovir

 

R10

Immunosuppression for islet TPL

Prophylactic use of ganciclovir

 

R11

Immunocompetence

Prophylactic use of ganciclovir

 

R12

Immunocompetence

Prophylactic use of ganciclovir

 

R13

Immunocompetence

Prophylactic use of ganciclovir

 

R14

Immunocompetence

Prophylactic use of ganciclovir