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Table 2 Effect of Gαq-RGS2 signaling inhibitor on organ-to body weight ratio (%) of various organs

From: Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor

Organ

NC

VC

T10

T100

Heart

0.289 ± 0.026

0.268 ± 0.015

0.290 ± 0.019

0.284 ± 0.027

Kidney

0.544 ± 0.04

0.534 ± 0.075

0.608 ± 0.07

0.562 ± 0.063

Liver

2.010 ± 0.222

1.929 ± 0.207

2.263 ± 0.221

2.175 ± 0.287

Brain

0.681 ± 0.018

0.690 ± 0.035

0.752 ± 0.032

0.659 ± 0.019

Lung

0.331 ± 0.036

0.346 ± 0.029

0.393 ± 0.036

0.387 ± 0.011

  1. NC = , Normal control, VC = 1 % DMSO treated normal rats, T10 = Gαq-RGS2 signaling inhibitor (10 mg/kg) treated rats and T100 = Gαq-RGS2 signaling inhibitor (100 mg/kg) treated rats. (n = 6/each group)
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Laboratory Animal Research

ISSN: 2233-7660