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Fig. 2 | Laboratory Animal Research

Fig. 2

From: Hypothermic treatment reduces matrix metalloproteinase-9 expression and damage in the liver following asphyxial cardiac arrest in rats

Fig. 2

Immunohistochemical staining for MMP9 in the liver sections of the normothermia (NT; A-E) and hypothermia (HT; a-e) groups at sham, 6 h, 12 h, 1 day, and 2 days after asphyxial cardiac arrest (ACA). MMP9 immunoreactivity in the NT-CA and HT-CA groups is markedly increased from 6 h and continued to increase until 2 days after ACA. In the HT-CA group, MMP9 immunoreactivity is significantly lower than those in the corresponding NT-CA groups after ACA. CV: central vein. Scale bar = 50 μm. (F) Relative optical density (ROD) of MMP9 immunoreactivity in the normothermia and hypothermia groups (n = 5 at each point in time after sham-operation, n = 11 at each point in time after ACA, *P < 0.05, significantly different from sham group; P < 0.05; significantly different from previous time-point group; #P < 0.05, significantly different from NT-CA group). Bars indicate means ± standard error of the mean

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