Fig. 3

Scoring of intestinal lesions. (A, B) Number, load and average size of colonic lesions in B6 or A/J mice treated with AOM/DSS (++) or AOM only (+). Lesions were categorized as either ACFs (≤30 abnormal crypts) or tumors (≥30 abnormal crypts). Box plots show median (line), mean (+), IQR (box) and minimum to maximum (whiskers). Statistical significance between strains treated with AOM/DSS or AOM only was determined by Mann-Whitney U tests (**p ≤ 0.01). (C) Size distribution of lesions in colons of B6 and A/J mice. Data is presented as median number of lesions in each lesion size category for each group, plotted by treatment. The smallest size category includes lesions with 1–4 aberrant crypts, while lesions are considered tumors if they contain ≥30 abnormal crypts per lesion (0.4 mm²). (D) Number, load and average size of small intestinal lesions in B6 or A/J mice treated with AOM/DSS (++) or AOM only (+). Box plots show median (line), mean (+), IQR (box) and minimum to maximum (whiskers)