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Fig. 5 | Laboratory Animal Research

Fig. 5

From: Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model

Fig. 5Fig. 5

Genes set pertaining to mitochondrial biogenesis and respiration are enriched as a result of higher tidal volume. HALLMARK_MYC_TARGET_V1, REACTIVE_OXYGEN_SPECIES_PATHWAY and OXIDATIVE_PHOSPHORYLATION gene sets were enriched dependent on tidal volume increases (A–C). The top 10 genes with highest beta value from the appropriate gene sets are displayed beneath each graph. TNFA_SIGNALING_VIA_NFKB, DNA_REPAIR and UNFOLDED_PROTEIN_RESPONSE gene sets increase their NES scores with increased tidal volumes (D–F)

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Laboratory Animal Research

ISSN: 2233-7660