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Fig. 1 | Laboratory Animal Research

Fig. 1

From: Elucidating the characteristics of Mx1 and resistance to influenza A virus subtype H1N1 in the newly developed KWM/Hym mice

Fig. 1

The alignment of nucleotide sequences and amino acids in Mx1 of KWM/Hym mice. A The sequence of the Mx1 gene in KWM/Hym has variation at two positions (327T>C and 1839 A>G) compared to that in A2G mice (M. m. domesticus). The sequence of the Mx1 gene in KWM/Hym has variation with 4 and 38 sites compared to those in CAST/EiJ (M. m. castaneus) and M. spretus mice, respectively. B The KWM/Hym mice have two missense mutations (G83R, A222V) in the G domain of Mx1 protein compared to the protein in CAST/EiJ mice. The Mx1 protein in KWM/Hym compared to the protein in M. Spretus has 25 missense mutations, with 13 sites in the G domain, eight in the stalk domain, two in the loop L4 domain, and two in the bundle-signaling element domain. The amino acid sequences were aligned using the T-Coffee Multiple Sequence Alignment Program (https://www.ebi.ac.uk/Tools/msa/tcoffee/)

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Laboratory Animal Research

ISSN: 2233-7660