Fig. 2
From: Chlorogenic acid modulates the ubiquitin–proteasome system in stroke animal model
Chlorogenic acid (CGA) inhibits the decrease in ubiquitin–proteasome system proteins in the right ischemic cortex. Images of protein spots A of ubiquitin C-terminal hydrolase L1, ubiquitin thioesterase OTUB1, proteasome subunit α type 1, proteasome subunit α type 3, proteasome subunit β type 4, and hypoxanthine phosphoribosyltransferase in the cerebral cortex from vehicle + middle cerebral artery occlusion (MCAO), CGA + MCAO, vehicle + sham, and CGA + sham animals. MCAO significantly reduced the expression levels of the ubiquitin–proteasome system proteins and CGA treatment maintained the levels of these proteins. Each square indicates protein spots. Intensities of protein spots are represented as a ratio of intensity of each group to that of vehicle + sham group B. Data (n = 5 per group) are represented as the mean ± S.E.M. *p < 0.05, **p < 0.01