Fig. 1
From: SARS-CoV-2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID-19 model
Comparison of clinicopathological characteristics of Wuhan- and Omicron-infected K18-hACE2 mice. A K18-hACE2-transgenic mice inoculated with 1 × 105 PFU Wuhan and Omicron SARS-CoV-2 via the intranasal route. They were necropsied at 7 dpi. B The histopathological score of lung inflammation at 7 dpi was measured based on H&E slides. C Representative images of H&E staining of virus-infected lung tissues at 7 dpi. Boxed areas are magnified in the right panel. Scale bar = 500 μm (40×) and 100 μm (200×). D Viral burden in the lungs was measured at 7 dpi by TCID50. E The weight of the mice was monitored. Right graph, the individual values of the mice at 7 dpi. F The body temperature of the mice was monitored. Body temperature was presented with the difference from baseline. Baseline, the average body temperature of uninfected normal mice. Right graph, individual values of the mice at 7 dpi. Student’s-t test, *p < 0.05; **p < 0.01; ***p < 0.001. Error bars indicate the mean ± SD