Fig. 4
From: SARS-CoV-2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID-19 model
Lymphoid depletion in Omicron-infected mice with brain infection A Representative H&E images of the spleens from Omicron-infected K18-hACE2 mice with brain infection at 7 dpi. Arrow heads, apoptotic cells. B Histological scores of lymphoid depletion and apoptosis in white pulp of the spleen based on H&E slides. C Representative TUNEL images of the spleens from Omicron-infected K18-hACE2 mice with brain infection at 7 dpi. D Representative IF images of CD3 + T cells and CD19 + B cells in the spleen of an Omicron-infected K18-hACE2 mouse with brain infection at 7 dpi. CD3 (green), CD19 (red), and DAPI (blue; nucleus). Boxed areas were magnified in the right panel. Scale bar = 500 μm (40×), 200 μm (100×), 100 μm (200×), and 20 μm (1000×)