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Table 1 Effects of losartan, metformin, and glibenclamide on body weight of DOCA + STZ hypertensive diabetic rats

From: Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

Treatment

Initial

Week 4

Week 8

Normal Control

237.20 ± 3.61

296.40 ± 6.20

317.80 ± 9.17

HD Control

273.60 ± 6.23

190.00 ± 6.12*

167.40 ± 4.45*

HD + LOS + MET

261.80 ± 7.55

214.60 ± 11.91*

200.40 ± 12.42*

HD + LOS + GLB

259.60 ± 10.79

250.20 ± 12.23*#

235.00 ± 13.78*#

HD + LOS + MET + GLB

265.00 ± 7.76

247.20 ± 1.50*#

225.80 ± 3.20*#

  1. All values are expressed as mean ± SEM (n = 5). *P < 0.05 when compared with normal control; #P < 0.05 when compared with hypertensive diabetic control. (HD Control Hypertensive Diabetic Control, HD Hypertensive Diabetic Rats, LOS Losartan, MET Metformin, GLB Glibenclamide)
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Laboratory Animal Research

ISSN: 2233-7660