Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

Table 2 Effects of losartan, metformin and glibenclamide on 2-hourly fasting blood sugar level of DOCA + STZ hypertensive diabetic rats

Treatment	Post-induction (mg/dL)	2nd Hour	4th Hour	6th Hour
Normal Control	84.40 ± 2.69	76.40 ± 2.69	79.60 ± 2.20	72.80 ± 0.49
HD Control	354.60 ± 2.09	354.00 ± 1.79^*	359.60 ± 3.36^*	349.60 ± 1.83^*
HD + LOS + MET	361.20 ± 7.84	290.40 ± 13.72^*#	274.00 ± 8.57^*#	256.00 ± 2.45^*#
HD + LOS + GLB	329.60 ± 6.73	288.60 ± 3.80^*#	246.80 ± 4.03^*#a	225.20 ± 2.80^*#a
HD + LOS + MET + GLB	382.00 ± 3.51	303.40 ± 7.45^*#	261.40 ± 8.54^*#	238.60 ± 5.67^*#a

All values are expressed as mean ± SEM (n = 5). *P < 0.05 when compared with normal control; ^#P < 0.05 when compared with hypertensive diabetic control; ^aP < 0.05 when compared with LOS + MET treatment. (HD Control Hypertensive Diabetic Control, HD Hypertensive Diabetic Rats, LOS Losartan, MET Metformin, GLB Glibenclamide)

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