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Table 6 Effects of losartan, metformin and glibenclamide on mean arterial pressure (mmHg) of DOCA + STZ hypertensive diabetic rats

From: Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

Treatment

Initial

Week 1

Week 2

Week 3

Week 4

Week 8

Normal Control

74.00 ± 0.00

69.00 ± 3.00

76.00 ± 7.02

82.00 ± 8.00

79.33 ± 3.28

86.33 ± 5.81

HD Control

72.33 ± 2.67

99.33 ± 0.67*

107.33 ± 3.71*

115.00 ± 2.89*

123.00 ± 6.25*

102.33 ± 1.33

HD + LOS + MET

81.67 ± 8.33

89.67 ± 89.67*

99.00 ± 2.08*

101.33 ± 0.67

84.33 ± 2.85#

97.00 ± 3.21

HD + LOS + GLB

83.33 ± 3.33

89.33 ± 0.33*

91.67 ± 1.67

89.00 ± 4.00#

85.33 ± 2.91#

93.00 ± 0.58

HD + LOS + MET + GLB

84.67 ± 2.67

89.00 ± 4.00*

88.00 ± 3.00#

93.67 ± 1.33#

82.67 ± 2.67#

94.00 ± 5.13

  1. All values are expressed as mean ± SEM (n = 5). *P < 0.05 when compared with normal control; #P < 0.05 when compared with hypertensive diabetic control. (HD Control Hypertensive Diabetic Control, HD Hypertensive Diabetic Rats, LOS Losartan, MET Metformin, GLB Glibenclamide)