Fig. 4

Kossa stained tibia sections of female C57BL/6J mice and the occurrence of bone structure anomalies. Sections were magnified × 2.5. A example for no anomalies in the tibia section. B example for trabecularized cortical bone, mineralized lesions and anomalous trabecular localization in the tibia (here: epiphysis). C example for pseudocortical structures within the medullar cavity and the partial disruption of the growth plate. D bar plot of the percentage of animals within each housing condition CON (black), ENR (light blue) and SNE (green), that showed morphological anomalies with the respective p value from a χ² test. E bar plot of the number of morphological anomalies per animal within the three housing conditions (same coloring scheme)