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  1. The clinical use of sildenafil citrate (Viagra), a drug used to treat erectile dysfunction, is limited because of its many side effects on tissues. In this context, we aimed to investigate the protective effec...

    Authors: Ibrahim M. Ibrahim Laila, Samar HassabAllah Kassem and Marwa Salah ElDin Mohamed Diab
    Citation: Laboratory Animal Research 2023 39:22
    Content type: Research Published on:

  2. Globally, medicinal plants are used to treat diseases like diabetes. The present study evaluates the possible antioxidant, acute oral toxicity, the in-vitro and in-vivo antidiabetic potential of the hydro-ethanol...

    Authors: Alokali Kiba, Dipankar Saha and Bhrigu Kumar Das
    Citation: Laboratory Animal Research 2023 39:21
    Content type: Research Published on:

  3. Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatric disorders with morphological brain abnormalities. There is a growing body of evidence that abnormalities in the dop...

    Authors: Aysegul Gungor Aydin and Esat Adiguzel
    Citation: Laboratory Animal Research 2023 39:20
    Content type: Research Published on:

  4. Transient receptor potential canonical (TRPC) channels are non-selective cationic channels with permeability to Ca2+ and Na+. Despite their importance, there are currently few studies on TRPC in the periodontal l...

    Authors: Aeryun Kim, Ae Ri Kim, Yeong-Eui Jeon, Yun‑Jung Yoo, Yu-Mi Yang and Eun‑Jung Bak
    Citation: Laboratory Animal Research 2023 39:19
    Content type: Research Published on:

  6. The symbiosis between the Hawaiian bobtail squid Euprymna scolopes and bacterium Vibrio fischeri serves as a model for investigating the molecular mechanisms that promote the initial formation of animal-bacterial...

    Authors: Andrew G. Cecere, Rachel A. Cook and Tim I. Miyashiro
    Citation: Laboratory Animal Research 2023 39:17
    Content type: Research Published on:

  7. Liver fibrosis is an early stage of liver cirrhosis. As a reversible lesion before cirrhosis, liver failure, and liver cancer, it has been a target for drug discovery. Many antifibrotic candidates have shown p...

    Authors: Ji-Hee Hwang, Minyoung Lim, Gyeongjin Han, Heejin Park, Yong-Bum Kim, Jinseok Park, Sang-Yeop Jun, Jaeku Lee and Jae-Woo Cho
    Citation: Laboratory Animal Research 2023 39:16
    Content type: Research Published on:

  8. Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties. Hallucinations, confusion, agitation, aggressiveness, anxiety, and restlessness are reported am...

    Authors: Vincent Onoriode Igben, Wilson Josiah Iju, Omogbiya Adrian Itivere, John Chukwuma Oyem, Peter Sunday Akpulu and Efe Endurance Ahama
    Citation: Laboratory Animal Research 2023 39:15
    Content type: Research Published on:

  9. Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the dev...

    Authors: Emmanuelle Totain, Loïc Lindner, Nicolas Martin, Yolande Misseri, Alexandra Iché, Marie-Christine Birling, Tania Sorg, Yann Herault, Alain Bousquet-Melou, Pascale Bouillé, Christine Duthoit, Guillaume Pavlovic and Severine Boullier
    Citation: Laboratory Animal Research 2023 39:14
    Content type: Research Published on:

  12. Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia administration is an essential step for MCAo, but anestheti...

    Authors: Jinyoung Won, Zeeshan Ahmad Khan and Yonggeun Hong
    Citation: Laboratory Animal Research 2023 39:11
    Content type: Short Communication Published on:

  14. Enrichment of home cages in laboratory experiments offers clear advantages, but has been criticized in some respects. First, there is a lack of definition, which makes methodological uniformity difficult. Seco...

    Authors: Paul Mieske, Julia Scheinpflug, Timur Alexander Yorgan, Laura Brylka, Rupert Palme, Ute Hobbiesiefken, Juliane Preikschat, Lars Lewejohann and Kai Diederich
    Citation: Laboratory Animal Research 2023 39:9
    Content type: Research Published on:

  15. The Omicron variant has become the most prevalent SARS-CoV-2 variant. Omicron is known to induce milder lesions compared to the original Wuhan strain. Fatal infection of the Wuhan strain into the brain has bee...

    Authors: Na Yun Lee, Youn Woo Lee, Seung-Min Hong, Dain On, Gyeong Min Yoon, See-He An, Ki Taek Nam, Jun-Young Seo, Jeon-Soo Shin, Yang-Kyu Choi, Seung Hyun Oh, Jun-Won Yun, Ho Young Lee, Kang-Seuk Choi, Je Kyung Seong and Jun Won Park
    Citation: Laboratory Animal Research 2023 39:8
    Content type: Short Communication Published on:

  16. Hypertension is a medical condition that often comorbidly exist in patients with type II diabetes. Therefore, it is very important to manage both conditions simultaneously to mitigate the complications and mor...

    Authors: Emuesiri Goodies Moke, Eric Kelly Inanemo Omogbai, SammyDavies Ehiosu Osagie-Eweka, Adaeze Phina Uchendu, Odion Martha Obayuwana, Elizabeth Okoro-Akpandu and Benneth Ben-Azu
    Citation: Laboratory Animal Research 2023 39:7
    Content type: Research Published on:

  17. New findings in regenerative medicine have always been combined with numerous animal studies. Therefore, choosing the right translational animal model plays an important role in transferring as much basic know...

    Authors: Kamran Shirbache, Hossein Nematian and Mohammad Hossein Nabian
    Citation: Laboratory Animal Research 2023 39:6
    Content type: Short Communication Published on:

  18. Orthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant immunosuppressive therapy is important to prevent graft failure. We i...

    Authors: Min-Jung Park, Hyun Sik Na, Young-Shin Joo, Keun-Hyung Cho, Se-Young Kim, Jeong Won Choi, Jin-Ah Baek, Jong Young Choi, Young Kyoung You and Mi-La Cho
    Citation: Laboratory Animal Research 2023 39:5
    Content type: Research Published on:

  19. Cudrania tricuspidata is a perennial plant, and Sargassum fusiforme is a brown seaweed with numerous potential benefits, including anticancer, anti-inflammatory, and antioxidant activities. However, the efficacie...

    Authors: Priyanka Rajan, Premkumar Natraj, Nak Hyoung Kim, Jae-Hoon Kim, Hyuk Joon Choi and Chang-Hoon Han
    Citation: Laboratory Animal Research 2023 39:4
    Content type: Research Published on:

  20. Epigallocatechin gallate (EGCG) is a flavonoid compound commonly found in green tea. It exhibits antioxidant, anti-inflammatory, and neuroprotective effects in cerebral ischemia. Protein phosphatase 2 A (PP2A)...

    Authors: Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park and Phil Ok Koh
    Citation: Laboratory Animal Research 2023 39:3
    Content type: Research Published on:

  21. Recombination activating gene2 (Rag2) knockout (KO) mice are used widely in various research fields, including vaccine development, transplantation studies, and hematopoiesis research, but few studies have com...

    Authors: Yu Jeong Roh, Jeong Eun Gong, Ji Eun Kim, You Jeong Jin, Hee Jin Song, Ayun Seol, Jumin Park, Yong Lim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2023 39:2
    Content type: Research Published on:

  22. Disruptions of the intestinal epithelial barrier (IEB) are frequently observed in various digestive diseases, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). This study assessed ...

    Authors: Ji Eun Kim, Hee Jin Song, Yun Ju Choi, You Jeong Jin, Yu Jeong Roh, Ayun Seol, So Hae Park, Ju Min Park, Hyun Gu Kang and Dae Youn Hwang
    Citation: Laboratory Animal Research 2023 39:1
    Content type: Research Published on:

  24. Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals...

    Authors: Siavash Ahmadi-Noorbakhsh, Mohammad Farajli Abbasi, Maedeh Ghasemi, Gholamreza Bayat, Nahid Davoodian, Ehsan Sharif-Paghaleh, Seyedeh Mahsa Poormoosavi, Melika Rafizadeh, Maryam Maleki, Hesamaddin Shirzad-Aski, Hossein Kargar Jahromi, Masoomeh Dadkhah, Bahman Khalvati, Tahereh Safari, Mohammad Amin Behmanesh, Seyed Esmaeil Khoshnam…
    Citation: Laboratory Animal Research 2022 38:40
    Content type: Review Published on:

  25. Fameyes (a mixture of Clematis mandshurica Rupr. extract (CMRE) and Erigeron annuus (L.) Pers. extract (EAPE)) containing scutellarin and chlorogenic acid as major components has been reported to relieve mental s...

    Authors: Junkee Hong, Tae-Kyeong Lee, In Hye Kim, Seungah Lee, Byung-Ju Jeon, Jiwon Lee, Moo-Ho Won and Sungsu Kim
    Citation: Laboratory Animal Research 2022 38:39
    Content type: Research Published on:

  28. Resistance exercise training is known to improve metabolic disorders, such as obesity and type2 diabetes. In this study, we investigated whether the beneficial effects of resistance exercise training persisted...

    Authors: Hye Jin Kim, Youn Ju Kim, Il Yong Kim and Je Kyung Seong
    Citation: Laboratory Animal Research 2022 38:36
    Content type: Research Published on:

  29. Obstructive jaundice induces oxidative changes in the brain parenchyma and plays significant role in clinical manifestations of hepatic encephalopathy. We aim to study the progression of the brain oxidative st...

    Authors: Konstantinos Lilimpakis, Aidona Tsepelaki, Electra Kalaitzopoulou, Dimitrios Zisimopoulos, Polyxeni Papadea, Marianna Skipitari, Athina Varemmenou, Apostolos Aggelis, Constantine Vagianos, Constantine Constantoyannis and Christos D. Georgiou
    Citation: Laboratory Animal Research 2022 38:35
    Content type: Research Published on:

  30. The Asian federation of laboratory animal science associations (AFLAS) was established on November 29, 2003, and will celebrate its 20th anniversary in 2023. During this time, the number of AFLAS member associ...

    Authors: Noriyuki Kasai
    Citation: Laboratory Animal Research 2022 38:34
    Content type: Review Published on:

  31. Nonhuman primates are used for research purposes such as studying diseases and drug discovery and development programs. Various clinical pathology parameters are used as biomarkers of disease conditions in bio...

    Authors: Niraj A. Shah, Laxit K. Bhatt, Rajesh J. Patel, Tushar M. Patel, Nayankumar V. Patel, Harshida G. Trivedi, Nilam R. Patel, Jitendra H. Patel, Satish D. Patel, Rajesh S. Sundar and Mukul R. Jain
    Citation: Laboratory Animal Research 2022 38:33
    Content type: Research Published on:

  32. In vivo molecular imaging is a research field in which molecular biology and advanced imaging techniques are combined for imaging molecular-level biochemical and physiological changes that occur in a living bo...

    Authors: Su Jin Kim and Ho-Young Lee
    Citation: Laboratory Animal Research 2022 38:31
    Content type: Review Published on:

  33. Given its similar structure and immune response to the human skin, porcine is a good model for dermal studies. Here, we sensitized ovalbumin (Ova) on minipig back skin for 2–4 weeks to induce chronic atopic de...

    Authors: Young Kyu Kim, JuKyung Lee, Hyeon-Young Kim, Sung-Hwan Kim, Jeong Ho Hwang and Han Na Suh
    Citation: Laboratory Animal Research 2022 38:32
    Content type: Research Published on:

  34. All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J,...

    Authors: Kristine Eraker Aasland Hansen, Alexandra M. Hudecová, Fred Haugen, Eystein Skjerve, Erik Ropstad and Karin E. Zimmer
    Citation: Laboratory Animal Research 2022 38:30
    Content type: Research Published on:

  35. Now that it is possible to efficiently classify and save tissue images of laboratory animals using whole-slide imaging, many diagnostic models are being developed through transfer learning with Convolutional N...

    Authors: Jong Su Byun, Ji Hyun Lee, Jin Seok Kang and Beom Seok Han
    Citation: Laboratory Animal Research 2022 38:29
    Content type: Research Published on:

  36. Inbred mice have several advantages, including genetic similarity to humans, a well-established gene manipulation system, and strong tolerance to inbreeding. However, inbred mice derived from a limited genetic...

    Authors: Hajin Nam, Boyoung Kim, Avishekh Gautam, Yoo Yeon Kim, Eun Sun Park, Jong Sun Lee, Hyung-Joo Kwon, Je Kyung Seong and Jun Gyo Suh
    Citation: Laboratory Animal Research 2022 38:28
    Content type: Research Published on:

  37. The Institutional Animal Care and Use Committee (IACUC) became compulsory in 2008 by the Animal Protection Act in Korea. Seoul National University (SNU), which conducts 5% of Korea’s total animal protocol revi...

    Authors: Na Ahn, Jaehak Park, Jungjoon Ihm and Sangho Roh
    Citation: Laboratory Animal Research 2022 38:27
    Content type: Research Published on:

  38. Calcium carbide (CaC2) is a chemical primarily used in the production of acetylene gas. The misuse of CaC2 to induce fruit ripening is a global challenge with a potential adverse effects to human health. Addition...

    Authors: Pherah A. Ouma, Victoria K. Mwaeni, Peris W. Amwayi, Alfred Orina Isaac and James Nyabuga Nyariki
    Citation: Laboratory Animal Research 2022 38:26
    Content type: Research Published on:

  40. Rabbits are being increasingly used as companion animals, and in research; thus, the need for proper veterinary care for rabbits has increased. Surgical access is more challenging in rabbits under inhalation a...

    Authors: Yujin Kim, Hee Yeon Jeon, Insook Yang, Ji Hyun Kim, Jae Hee Chung, Ji-Hyeon Ju, Gyeonghun Kim, Jun Won Park, Seung Yeon Oh, Je Kyung Seong, Seung Hyun Oh and Young-Shin Joo
    Citation: Laboratory Animal Research 2022 38:24
    Content type: Short Communication Published on:

  41. Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas exchange in the lungs. Ventilator-induced lung injury (VILI) is an un...

    Authors: Jon Petur Joelsson, Arni Asbjarnarson, Snaevar Sigurdsson, Jennifer Kricker, Bryndis Valdimarsdottir, Holmfridur Thorarinsdottir, Eir Starradottir, Thorarinn Gudjonsson, Saevar Ingthorsson and Sigurbergur Karason
    Citation: Laboratory Animal Research 2022 38:23
    Content type: Research Published on:

  42. To systematically evaluate the effects of metformin on tumors in experimental animal models of different types of cancer. Pubmed, Embase, Cochrane, and Web of Science databases were searched for studies on met...

    Authors: Fan Zhang, Shuai Han and Weijie Song
    Citation: Laboratory Animal Research 2022 38:22
    Content type: Short Communication Published on:

  43. Neuroinflammation plays an important role in cognitive decline and memory impairment in neurodegenerative disorders. Previously, we demonstrated that Humulus japonicus (HJ) has anti-inflammatory effects in rodent...

    Authors: Jun Go, Hye-Yeon Park, Da Woon Lee, So-Young Maeng, In-Bok Lee, Yun Jeong Seo, Jin-Pyo An, Won Keun Oh, Chul-Ho Lee and Kyoung-Shim Kim
    Citation: Laboratory Animal Research 2022 38:21
    Content type: Research Published on:

  44. Gastrointestinal microbiota, which comprises hundreds of different types of microbes, biologically plays crucial roles in the host’s health. Probiotics (PRO) did not always have a positive benefit on the host,...

    Authors: Min-Jeong Kim, Dong-Gyeong Jeon, Yong Lim and Insurk Jang
    Citation: Laboratory Animal Research 2022 38:20
    Content type: Research Published on:

  46. The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human. Discovery of a drug and/or component, equipment,...

    Authors: P. Mukherjee, S. Roy, D. Ghosh and S. K. Nandi
    Citation: Laboratory Animal Research 2022 38:18
    Content type: Review Published on:

  47. As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus dis...

    Authors: Suhyeon Yoon, Hyuna Noh, Heejin Jin, Sungyoung Lee, Soyul Han, Sung-Hee Kim, Jiseon Kim, Jung Seon Seo, Jeong Jin Kim, In Ho Park, Jooyeon Oh, Joon-Yong Bae, Gee Eun Lee, Sun-Je Woo, Sun-Min Seo, Na-Won Kim…
    Citation: Laboratory Animal Research 2022 38:17
    Content type: Research Published on:

  48. Intravital imaging via two-photon microscopy (TPM) is a useful tool for observing and delineating biological events at the cellular and molecular levels in live animals in a time-lapse manner. This imaging met...

    Authors: Da Jeong Byun, Young Min Kim and Young-Min Hyun
    Citation: Laboratory Animal Research 2022 38:16
    Content type: Review Published on:

  50. The use of animals in biomedical science remains controversial. An individual’s level of concern is generally influenced by their culture, previous or current experience with animals, and the specific animal s...

    Authors: Olatz Goñi-Balentziaga, Iván Ortega-Saez, Sergi Vila and Garikoitz Azkona
    Citation: Laboratory Animal Research 2022 38:14
    Content type: Research Published on:
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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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Laboratory Animal Research

ISSN: 2233-7660