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  1. Mulberry (Morus alba) leaves are known to have therapeutic effects on lipid metabolism including lipogenesis, lipolysis and hyperlipidemia. However, novel compounds with strong lipolytic ability among 27 extracts...

    Authors: Mi Rim Lee, Ji Eun Kim, Woo Bin Yun, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Whan Choi, Kyung Mi Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2017 33:3303270

    Content type: OriginalPaper

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  2. Angelica acutiloba (AA), a Japanese species of Danggui, has been used worldwide as a traditional herbal medicine with several bioactivities including anti-diabetic, anti-allergic, anti-inflammatory, anti-tumor, a...

    Authors: Jun-Won Yun, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Yun-Soon Kim, In Ae Park, Hyeon Hoe Kim, Jeong-Hwan Che and Byeong-Cheol Kang

    Citation: Laboratory Animal Research 2017 33:3303223

    Content type: OriginalPaper

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  3. Artemisia argyi is used as a health supplement, tea, and food source in Korea. This study aimed to evaluate the effect of Artemisia argyi (AA) and its active compound, dehydromatricarin A (DA), on the attenuation...

    Authors: Na-Rae Shin, Sung-Hyeuk Park, Je-Won Ko, Hyung-Won Ryu, Seong-Hun Jeong, Jong-Choon Kim, Dong-Ho Shin, Hoon-Sang Lee and In-Sik Shin

    Citation: Laboratory Animal Research 2017 33:3303209

    Content type: OriginalPaper

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  4. Korl:ICR mice, established by the Korean National Institute of Food and Drug Safety Evaluation (NIFDS), are characterized based on their genetic variation, response to gastric injury, and response to constipat...

    Authors: Ji Eun Sung, Ji Eun Kim, Hyun Ah Lee, Woo Bin Yun, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Suk Jung, Kil Soo Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2017 33:3302187

    Content type: OriginalPaper

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  5. C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neu...

    Authors: Woo Bin Yun, Hye Ryeong Kim, Ji Eun Kim, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Young Suk Jung, Hyun Keun Song, Joon Young Cho, Kil Soo Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2017 33:3302179

    Content type: OriginalPaper

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  6. Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual ten...

    Authors: Ji Eun Kim, Jung Hoon Nam, Joon Young Cho, Kil Soo Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2017 33:3302171

    Content type: OriginalPaper

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  7. Doxorubicin is a widely used chemotherapeutic agents and is now part of standard therapeutic regimens for a variety of cancers (eg, hematopoietic malignancies and advanced solid tumors of the breast, ovary, th...

    Authors: Sou Hyun Kim, Keuk-Jun Kim, Joung-Hee Kim, Jae-Hwan Kwak, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung

    Citation: Laboratory Animal Research 2017 33:3302165

    Content type: OriginalPaper

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  8. Non-alcoholic fatty liver disease (NAFLD) is believed to be the most prevalent liver disease worldwide and a major cause of chronic liver injury. It is characterized by lipid accumulation in the absence of sig...

    Authors: Sou Hyun Kim, Yong Lim, Ju Bin Park, Jae-Hwan Kwak, Keuk-Jun Kim, Joung-Hee Kim, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung

    Citation: Laboratory Animal Research 2017 33:3302157

    Content type: OriginalPaper

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  9. This study was conducted to compare the multiple low-dose streptozotocin (MLDS)-induced diabetic patterns of Korl:ICR, A:ICR, and B:ICR mice obtained from three different sources. Six-week-old male ICR mice we...

    Authors: Do Yeon Lee, Myeong Hwan Kim, Hye Rin Suh, Young Suk Jung, Dae Youn Hwang and Kil Soo Kim

    Citation: Laboratory Animal Research 2017 33:3302150

    Content type: OriginalPaper

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  10. Animal model, as an indispensable tool for scientific purposes of biomedical researches and clinical application, is a commonly used in various researches. Regarding to this, it is necessary to establish the m...

    Authors: Dong-Ju Hwang, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang and Joon Young Cho

    Citation: Laboratory Animal Research 2017 33:3302140

    Content type: OriginalPaper

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  11. Adaptive immunity is a type of immune response mediated by T and B cells, and is important response for immune response amplification and memory. In this study, the adaptive immunologic properties of C57BL/6NK...

    Authors: Hye Ryeong Kim, Jun Young Choi, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2017 33:3302132

    Content type: OriginalPaper

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  12. Inbred mice, a systematically developed homogeneous animal, have been developed to maintain experimental reproducibility and to minimize experimental variables in animal-based studies. In particular, C57BL/6 m...

    Authors: Jun Young Choi, Hye Ryeong Kim, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2017 33:3302124

    Content type: OriginalPaper

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  13. Inbred mice are an essential animal strain for research as they can improve the reproducibility and reliability of study results. The establishment of new inbred lines is continuing, and new inbred lines are b...

    Authors: Hyun Keun Song and Dae Youn Hwang

    Citation: Laboratory Animal Research 2017 33:3302119

    Content type: Review

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  14. Glucose is essential for testicular function; the uptake of carbohydrate-derived glucose by cells is mediated by glucose transporters (GLUTs). In the present study, we investigated the activity of GLUT1 and GL...

    Authors: Kyu Ri Hahn, Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Yang Hee Kim, Young Kwang Jo, Geon A. Kim, Jin Young Chung, Jung Hoon Choi, In Koo Hwang, Goo Jang and Yeo Sung Yoon

    Citation: Laboratory Animal Research 2017 33:3302114

    Content type: Case Report

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  15. Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, b...

    Authors: Young-Hwan Ban, Yeseul Cha, Jieun Choi, Eun Suk An, Ji Young Lee, Nu Ry Han, Da Woom Seo, Gooyoung Jung, Da-Hye Jeong, Man Hee Rhee, Ehn-Kyoung Choi and Yun-Bae Kim

    Citation: Laboratory Animal Research 2017 33:3302105

    Content type: OriginalPaper

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  16. The objective of this study was to determine the effect of ionizing radiation (IR) exposure of parents on carcinogenesis of the next generation focusing on the epigenetic perspective to clarify the relationshi...

    Authors: Lan Li, Jong-Hyun Kim, Hee-Tae Park, Jae-Hoon Lee, Min-Koo Park, Ji-Won Lee, Jeong-Chan Lee and Min-Jae Lee

    Citation: Laboratory Animal Research 2017 33:3302092

    Content type: OriginalPaper

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  17. The usage of essential oils as antimicrobial agents is gaining attention. Besides, pet turtles were known to harbor a range of pathogenic bacteria while the turtle keeping is a growing trend worldwide.The curr...

    Authors: B. C. J. De Silva, Won-Gi Jung, Sabrina Hossain, S. H. M. P. Wimalasena, H. N. K. S. Pathirana and Gang-Joon Heo

    Citation: Laboratory Animal Research 2017 33:3302084

    Content type: OriginalPaper

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  18. Chronic obstructive pulmonary diseases (COPD) is an important disease featured as intense inflammation, protease imbalance, and air flow limitation and mainly induced by cigarette smoke (CS). In present study,...

    Authors: Je-Won Ko, Na-Rae Shin, Sung-Hyeuk Park, Joong-Sun Kim, Young-Kwon Cho, Jong-Choon Kim, In-Sik Shin and Dong-Ho Shin

    Citation: Laboratory Animal Research 2017 33:3302076

    Content type: OriginalPaper

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  19. The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading unde...

    Authors: Shikha Yadav, Inderjeet Yadav, Kunal Pratap, Pradeep Kumar Tiwari and Vijay Pal Singh

    Citation: Laboratory Animal Research 2017 33:3302068

    Content type: OriginalPaper

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  20. The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines ...

    Authors: Ji Eun Sung, Jun Young Choi, Ji Eun Kim, Hyun Ah Lee, Woo Bin Yun, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Dong Seob Kim, Chung Yeoul Lee, Hee Seob Lee, Yong Lim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2017 33:3302057

    Content type: OriginalPaper

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  21. Turtle-borne Salmonella enterica owns significance as a leading cause in human salmonellosis. The current study aimed to determine the quinolone susceptibility and the genetic characteristics of 21 strains of S. ...

    Authors: B. C. J. De Silva, Sabrina Hossain, S. H. M. P. Wimalasena, H. N. K. S. Pathirana, Mitchell Wendt and Gang-Joon Heo

    Citation: Laboratory Animal Research 2017 33:3302049

    Content type: OriginalPaper

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  22. HemoHIM, herbal preparation has designed for immune system recovery. We investigated the antiinflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulm...

    Authors: Na-Rae Shin, Sung-Ho Kim, Je-Won Ko, Sung-Hyeuk Park, In-Chul Lee, Jung-Min Ryu, Jong-Choon Kim and In-Sik Shin

    Citation: Laboratory Animal Research 2017 33:3301040

    Content type: OriginalPaper

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  23. The purpose of this study was to investigate the immunomodulatory activity of ice plant (Mesembryanthemum crystallinum) extract (IPE) in vitro and in vivo. Raji (a human B cell line) and Jurkat (a human T cell li...

    Authors: Joo-Hee Choi, Sung-Gang Jo, Seoung-Ki Jung, Woo-Tae Park, Keun-Young Kim, Yong-Wook Park and Jong-Hwan Park

    Citation: Laboratory Animal Research 2017 33:3301032

    Content type: OriginalPaper

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  24. The study was performed to see the effects of coenzyme Q10 (CoQ10) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats w...

    Authors: Min-Hae Song, Ha-Na Kim, Yong Lim and In-Surk Jang

    Citation: Laboratory Animal Research 2017 33:3301024

    Content type: OriginalPaper

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  25. Previous studies report positive effects of pentoxifylline (PTX) alone or in combination with other drugs on some pathologic bone diseases as well as an ability to accelerate osteogensis and fracture healing i...

    Authors: Mohammad Mahdi Vashghani Farahani, Reza Ahadi, Mohammadamin Abdollahifar and Mohammad Bayat

    Citation: Laboratory Animal Research 2017 33:3301015

    Content type: OriginalPaper

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  26. Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology, oncology, infect...

    Authors: Hye-Jun Shin, Young Min Cho, Hee Jung Shin, Hae Deun Kim, Kyung Min Choi, Mi Gyeong Kim, Hyoung Doo Shin and Myeon-Woo Chung

    Citation: Laboratory Animal Research 2017 33:3301008

    Content type: OriginalPaper

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  27. Circling mouse (C57BL/6J-cir/cir) deleted the transmembrane inner ear (Tmie) gene is an animal model for human non-syndromic recessive deafness, DFNB6. In circling mouse, hair cells in the cochlea have degenerate...

    Authors: Yoo Yeon Kim, Hajin Nam, Harry Jung, Boyoung Kim and Jun Gyo Suh

    Citation: Laboratory Animal Research 2017 33:3301001

    Content type: OriginalPaper

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  28. Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering ...

    Authors: Yun-Jung Choi, Hye-Jin Park, Chul-Ho Sohn, Kyeong Cheon Jung, Seong Hoe Park and Jae-Il Lee

    Citation: Laboratory Animal Research 2016 32:3204267

    Content type: Case Report

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  29. Transplantation of spermatogonial stem cells (SSCs) in experimental animal models has been used to study germ line stem cell biology and to produce transgenic animals. The species-specific recipient model prep...

    Authors: Won-Young Lee, Ran Lee, Hyuk Song, Tai-Young Hur, Seunghoon Lee, Jiyun Ahn and Hyunjhung Jhun

    Citation: Laboratory Animal Research 2016 32:3204257

    Content type: OriginalPaper

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  30. Alzheimer’s disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of hum...

    Authors: Woo Bin Yun, Jin Ju Park, Ji Eun Kim, Ji Eun Sung, Hyun Ah Lee, Jae Ho Lee, Chang Jun Bae and Dae Youn Hwang

    Citation: Laboratory Animal Research 2016 32:3204249

    Content type: OriginalPaper

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  31. Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects and the action mechanism of drugs against this disease. ICR mice were selected to produce ...

    Authors: Ji Eun Kim, Woo Bin Yun, Ji Eun Sung, Hyun Ah Lee, Jun Young Choi, Yeon Shik Choi, Young Suk Jung, Kil Soo Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2016 32:3204231

    Content type: OriginalPaper

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  32. We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationsh...

    Authors: Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Dae Won Kim, Jung Hoon Choi, Jin Young Chung, Moo-Ho Won, Yeo Sung Yoon and In Koo Hwang

    Citation: Laboratory Animal Research 2016 32:3204224

    Content type: OriginalPaper

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  33. This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats w...

    Authors: Myeong-Hwan Kim, Eun-Jin Lee, Jeong-Mu Cheon, Ki-Jun Nam, Tae-Ho Oh and Kil-Soo Kim

    Citation: Laboratory Animal Research 2016 32:3204217

    Content type: OriginalPaper

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  34. Our research sought to characterize the phylogeny of Pseudomonas aeruginosa isolated from pet Chinese stripe-necked turtles (Ocadia sinensis) to better understand its evolutionary relation to other isolates and i...

    Authors: Mitchell Wendt and Gang-Joon Heo

    Citation: Laboratory Animal Research 2016 32:3204208

    Content type: OriginalPaper

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  35. This study investigated the protective effects of diallyl disulfide (DADS) against acetaminophen (AAP)-induced acute renal injury in male rats. We also investigated the effects of DADS on kidney injury molecul...

    Authors: Jin-Young Shin, Ji-Hee Han, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, Tae-Yang Jung, Hyun-A Kim, Sung-Hwan Kim, In-Sik Shin and Jong-Choon Kim

    Citation: Laboratory Animal Research 2016 32:3204200

    Content type: OriginalPaper

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  36. Dynamin-like protein I (DLP-1) is an important mitochondrial fission and fusion protein that is associated with apoptotic cell death in neurodegenerative diseases. In this study, we investigated DLP-1 expressi...

    Authors: Ah-Ram Jang and Phil-Ok Koh

    Citation: Laboratory Animal Research 2016 32:3204194

    Content type: OriginalPaper

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  37. The purpose of this study was to delineate the various factors that affect the growth characteristics of human cancer xenografts in nude mice and to reveal the relationship between the growth characteristics a...

    Authors: Ji Young Lee, Mi-Sook Kim, Eun Ho Kim, Namhyun Chung and Youn Kyoung Jeong

    Citation: Laboratory Animal Research 2016 32:3204187

    Content type: OriginalPaper

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  38. Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [po...

    Authors: Yawon Hwang and Gonhyung Kim

    Citation: Laboratory Animal Research 2016 32:3204181

    Content type: OriginalPaper

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  39. Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD contai...

    Authors: Yeseul Cha, Ja Young Jang, Young-Hwan Ban, Haiyu Guo, Kyungha Shin, Tae-Su Kim, Sung-Pyo Lee, Jieun Choi, Eun-Suk An, Da-Woom Seo, Jung-Min Yon, Ehn-Kyoung Choi and Yun-Bae Kim

    Citation: Laboratory Animal Research 2016 32:3203179

    Content type: OriginalPaper

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  40. Pet turtles are known as a source of Salmonella infection to humans when handled in captivity. Thirty four turtles purchased from pet shops and online markets in Korea were examined to determine whether the turtl...

    Authors: Du-San Back, Gee-Wook Shin, Mitchell Wendt and Gang-Joon Heo

    Citation: Laboratory Animal Research 2016 32:3203166

    Content type: OriginalPaper

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  41. The approach and novelty of this scientific work was to formulate the appropriate Streptozotocin (STZ) and Alloxan dosage in different routes of administration to imply minimum mortality rate and high incidenc...

    Authors: Ataroalsadat Mostafavinia, Abdodlah Amini, Seyed Kamran Ghorishi, Ramin Pouriran and Mohammad Bayat

    Citation: Laboratory Animal Research 2016 32:3203160

    Content type: OriginalPaper

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  42. Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. ...

    Authors: Seungho Choi, Jong-Kyu Woo, Yeong-Su Jang, Ju-Hee Kang, Jung-Eun Jang, Tae-Hoo Yi, Sang-Yong Park, Sun-Yeou Kim, Yeo-Sung Yoon and Seung Hyun Oh

    Citation: Laboratory Animal Research 2016 32:3203151

    Content type: OriginalPaper

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  43. Dendrobium moniliforme (L.) Sw., an herb of the Orchidaceae family, has long been used in traditional medicine to strengthen bones, nourish the stomach, and promote the production of bodily fluid. Recently, polys...

    Authors: Mu-Jin Lee, Ho-Kyung Jung, Min-Suk Kim, Ji-Hun Jang, Mi-Ok Sim, Tea-Mook Kim, Ho Park, Byung-Kwan Ahn, Hyun-Woo Cho, Jung-Hee Cho, Won-Seok Jung and Jong-Choon Kim

    Citation: Laboratory Animal Research 2016 32:3203144

    Content type: OriginalPaper

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  44. The aim of this study was to examine the therapeutic potential of sulfasalazine and prednisolone in a mouse collagen antibody-induced arthritis (CAIA) model. Twenty-five male BALB/c mice were randomly divided ...

    Authors: Joo Hye Sim, Won Kil Lee, Yun Seok Lee and Jin Seok Kang

    Citation: Laboratory Animal Research 2016 32:3203135

    Content type: OriginalPaper

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  45. We designed 4 primers for amplification of allelespecific PCR products from leptin receptor mutant and normal alleles using primer design web service for tetraprimer ARMS-PCR (Figure 1) i.e., Lepr-forward oute...

    Authors: Harry Jung, Hajin Nam and Jun-Gyo Suh

    Citation: Laboratory Animal Research 2016 32:3202133

    Content type: Erratum

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    The original article was published in Laboratory Animal Research 2016 32:9

  46. Whereas increasing concerns about radiation exposure to nuclear disasters or side effects of anticancer radiotherapy, relatively little research for radiation damages or remedy has been done. The purpose of th...

    Authors: Seung-Hyun Ryu, Jong-Hyung Park, Eui-Suk Jeong, Soo-Young Choi, Seung-Hoon Ham, Jin-Il Park, Hee-Yeon Jeon, Jun-Young Kim, Ran-Ji Yoo, Yong-Jin Lee, Sang-Keun Woo and Yang-Kyu Choi

    Citation: Laboratory Animal Research 2016 32:3202116

    Content type: OriginalPaper

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Affiliated with


  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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