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  1. Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferati...

    Authors: Hyo Young Jung, Dae Young Yoo, Young Kwang Jo, Geon A. Kim, Jin Young Chung, Jung Hoon Choi, Goo Jang and In Koo Hwang

    Citation: Laboratory Animal Research 2016 32:3202128

    Content type: Case Report

    Published on:

  2. To investigate the beneficial effects of diosgenin (DC) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were measured ...

    Authors: Eun-Kyoung Koh, Woo-Bin Yun, Ji-Eun Kim, Sung-Hwa Song, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Seung-Wan Jee, Chang-Joon Bae and Dae-Youn Hwang

    Citation: Laboratory Animal Research 2016 32:3202105

    Content type: OriginalPaper

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  3. Helicobacter pylori colonizes the gastric mucosa of about half of the world’s population, causing chronic gastritis and gastric cancer. An increasing emergence of antibiotic-resistant H. pylori arouses demand on ...

    Authors: Dong-Jae Kim, Min-Jung Kang, Jin-A Choi, Dae-Seung Na, Jin-Beom Kim, Chun-Soo Na and Jong-Hwan Park

    Citation: Laboratory Animal Research 2016 32:3202099

    Content type: OriginalPaper

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  4. The aim of this study is to investigate the potential of anti-osteoarthritis effects on egg white-chalcanthite (EC), purple bamboo salts (PBS), and a mixture of EC and PBS (EC+PBS). EC is a mixture of egg whit...

    Authors: Tae-Hee Lee, Hyun-kyung Song, Ja-Young Jang, Dong-Yoon Kim, Hyun-Kyung Park, Eun-A Choi and Beom-Seok Han

    Citation: Laboratory Animal Research 2016 32:3202091

    Content type: OriginalPaper

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  5. The antibacterial activities of the essential oil of Eucalyptus globulus (EOEG) was determined against 7 fish pathogenic bacteria (Edwardsiella tarda, Streptococcus iniae, S. parauberis, Lactococcus garviae, Vibr...

    Authors: Joon-Woo Park, Mitchell Wendt and Gang-Joon Heo

    Citation: Laboratory Animal Research 2016 32:3202087

    Content type: OriginalPaper

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  6. Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pat...

    Authors: Hyun-Kyu Park, Jae-Woo Cho, Byoung-Seok Lee, Heejin Park, Ji-Seok Han, Mi-Jin Yang, Wan-Jung Im, Do-Yong Park, Woo-Jin Kim, Su-Cheol Han and Yong-Bum Kim

    Citation: Laboratory Animal Research 2016 32:3202079

    Content type: OriginalPaper

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  7. A 19-month-old male German shepherd dog was presented with a hindlimb footpad mass. The mass was excised and histopathology was performed. Grossly, the cut section of the mass had multiple wellcircumscribed no...

    Authors: Eun-Mi Lee, Ah-Young Kim, Eun-Joo Lee and Kyu-Shik Jeong

    Citation: Laboratory Animal Research 2016 32:10

    Content type: Case Report

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  8. The C57BLKS/J-Leprdb mouse has a point mutation in the leptin receptor gene and is one of the most useful animal model for non-insulin dependent diabetes mellitus in human. Since the homozygote of C57BLKS/J-Leprd...

    Authors: Harry Jung, Hajin Nam and Jun-Gyo Suh

    Citation: Laboratory Animal Research 2016 32:9

    Content type: Letter

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  9. Animal models for gastric ulcers produced by physical, pharmacological and surgical methods have been widely employed to evaluate therapeutic drugs and investigate the mechanism of action of this disease. ICR ...

    Authors: Sung Hwa Song, Ji Eun Kim, Jun Go, Eun Kyoung Koh, Ji Eun Sung, Hyun Ah Lee, Kyung Min Choi, Hae Deun Kim, Young Suk Jung, Kil Soo Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2016 32:7

    Content type: OriginalPaper

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  10. Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys t...

    Authors: Kangmoo Choi, Jaejin Chang, Min-Jae Lee, Seungsu Wang, Kimhong In, Wilhelm C. Galano-tan, Sanghun Jun, Kahee Cho, Yong-Hwa Hwang, Sung-Ju Kim and Wanje Park

    Citation: Laboratory Animal Research 2016 32:6

    Content type: OriginalPaper

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  11. Asparagus cochinchinensis has been used to treat various diseases including fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease, while IL-4 cytokine has been considered as key regu...

    Authors: Ji-Eun Sung, Hyun-Ah Lee, Ji-Eun Kim, Jun Go, Eun-Ji Seo, Woo-Bin Yun, Dong-Seob Kim, Hong-Joo Son, Chung-Yeoul Lee, Hee-Seob Lee and Dae-Youn Hwang

    Citation: Laboratory Animal Research 2016 32:5

    Content type: OriginalPaper

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  12. In this study, the potential hepatotoxicity of 1,3-dichloro-2-propanol and its hepatotoxic mechanisms in rats was investigated. The test chemical was administered orally to male rats at 0, 27.5, 55, and 110 mg...

    Authors: In-Chul Lee, Sang-Min Lee, Je-Won Ko, Sung-Hyeuk Park, In-Sik Shin, Changjong Moon, Sung-Ho Kim and Jong-Choon Kim

    Citation: Laboratory Animal Research 2016 32:4

    Content type: OriginalPaper

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  13. A dysfunction of endoplasmic reticulum (ER) stress response can result in various diseases, including cancer, inflammation, diabetes and neurodegenerative disorders. To investigate whether ER stress response c...

    Authors: Ji-Eun Kim, Jun Go, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Woo-Bin Yun and Dae-Youn Hwang

    Citation: Laboratory Animal Research 2016 32:3

    Content type: OriginalPaper

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  14. The purpose of this study was to evaluate the effects of thiopental versus propofol on cardiopulmonary functions, when used as an induction agent prior to isoflurane anesthesia in rhesus monkeys. Eight healthy...

    Authors: Yun-Jung Choi, Hye-Jin Park, Hyeon-Ho Kim, Yun-Jin Lee, Kyeong-Cheon Jung, Seong-Hoe Park and Jae-Il Lee

    Citation: Laboratory Animal Research 2016 32:2

    Content type: OriginalPaper

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  15. In this study, we observed the ontogenetic changes in glucose transporter 3 (GLUT3) immunoreactivity, a major neuronal GLUT, in the dentate gyrus of mouse brains at various ages: postnatal day (P) 1, 7, 14, 28...

    Authors: Hyo Young Jung, Hee Sun Yim, Dae Young Yoo, Jong Whi Kim, Jin Young Chung, Je Kyung Seong, Yeo Sung Yoon, Dae Won Kim and In Koo Hwang

    Citation: Laboratory Animal Research 2016 32:1

    Content type: OriginalPaper

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  16. As the request of the authors, the following information has been changed.

    Authors: Jangbeen Kyung, Dajeong Kim, Dongsun Park, Yun-Hui Yang, Ehn-Kyoung Choi, Sung-Pyo Lee, Tae-Su Kim, Yoon-Bok Lee and Yun-Bae Kim

    Citation: Laboratory Animal Research 2015 31:3103153

    Content type: Erratum

    Published on:

    The original article that this is related to.

  17. In order to assess inhibitory potentials of white rose petal extracts (WRPE) on the activities of enzymes related to dermal aging according to the extraction conditions, three extraction methods were adopted. ...

    Authors: Ehn-Kyoung Choi, Haiyu Guo, Jae-Kwon Choi, Su-Kil Jang, Kyungha Shin, Ye-Seul Cha, Youngjin Choi, Da-Woom Seo, Yoon-Bok Lee, Seong-Soo Joo and Yun-Bae Kim

    Citation: Laboratory Animal Research 2015 31:3103148

    Content type: Letter

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  18. The aim of this study was to verify subacute oral dose toxicity of positively charged 100 nm zinc oxide (ZnOAE100[+]) nanoparticles (NPs) in Sprague-Dawley rats. ZnOAE100[+] NPs were administered to rats of each ...

    Authors: Je-Won Ko, Eun-Taek Hong, In-Chul Lee, Sung-Hyeuk Park, Jong-Il Park, Nak-Won Seong, Jeong-Sup Hong, Hyo-In Yun and Jong-Choon Kim

    Citation: Laboratory Animal Research 2015 31:3103139

    Content type: Letter

    Published on:

  19. Curcumin provides various biological effects through its anti-inflammatory and antioxidant properties. Moreover, curcumin exerts a neuroprotective effect against ischemic condition-induced brain damage. Protei...

    Authors: Fawad-Ali Shah, Dong-Ju Park, Sang-Ah Gim and Phil-Ok Koh

    Citation: Laboratory Animal Research 2015 31:3103134

    Content type: Letter

    Published on:

  20. Some polymers and bioactive compounds derived from Styela clava tunic (SCT) have been reported as traditional medicine for the treatment of inflammation, oxidative stress and surgical wounds although there is lit...

    Authors: Eun-Kyoung Koh, Ji-Eun Sung, Ji-Eun Kim, Jun Go, Sung-Hwa Song, Hyun-Ah Lee, Hong-Joo Son, Young-Jin Jung, Yong Lim and Dae-Youn Hwang

    Citation: Laboratory Animal Research 2015 31:3103125

    Content type: OriginalPaper

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  21. This study was conducted to investigate the effects of lutein alone or in combination with vitamin C on the antioxidant defense system in rats. A total of 18 eight-week-old male Sprague Dawley (SD) rats were r...

    Authors: Min-Hae Song, Eu-Chul Shin, Dae-Youn Hwang and In-Surk Jang

    Citation: Laboratory Animal Research 2015 31:3103117

    Content type: OriginalPaper

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  22. The effect of pentoxifylline (PTX) administration on histomorphological parameters of streptozotocin (STZ)-induced type 1 diabetes mellitus (DM) in male rat testes were evaluated. We randomly divided 40 male r...

    Authors: Abbas Piryaei, Azam Najar and Mohammad Bayat

    Citation: Laboratory Animal Research 2015 31:3103111

    Content type: OriginalPaper

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  23. To evaluate the hepatotoxicity and nephrotoxicity of Galla Rhois (GR) toward the liver and kidney of ICR mice, alterations in related markers including body weight, organ weight, urine composition, liver patho...

    Authors: Jun Go, Ji-Eun Kim, Eun-Kyoung Koh, Sung-Hwa Song, Ji-Eun Seung, Chan-Kyu Park, Hyun-Ah Lee, Hong-Sung Kim, Jae-Ho Lee, Beum-Soo An, Seung-Yun Yang, Yong Lim and Dae-Youn Hwang

    Citation: Laboratory Animal Research 2015 31:3103101

    Content type: OriginalPaper

    Published on:

  24. As the request of the authors, the following information has been changed.

    Authors: Jingmei Cai, Tae-Su Kim, Ja Young Jang, Jihyun Kim, Kyungha Shin, Sung-Pyo Lee, Ehn-Kyoung Choi, Sa-Hyun Kim, Min Park, Jong Bae Kim and Yun-Bae Kim

    Citation: Laboratory Animal Research 2015 31:3102099

    Content type: Erratum

    Published on:

    The original article that this is related to.

  25. We developed pancreatic and duodenal homeobox1 (Pdx1) knockout mice to improve a compensatory hyperinsulinemia, which was induced by hyperplasia in the β cells or Langerhans’ islands, as the diabetic model mice. ...

    Authors: Haruo Hashimoto, Tsutomu Kamisako, Takahiro Kagawa, Seiki Haraguchi, Mika Yagoto, Ri-ichi Takahashi, Kenji Kawai and Hiroshi Suemizu

    Citation: Laboratory Animal Research 2015 31:3102093

    Content type: Letter

    Published on:

  26. A number of Helicobacter species may confound experimental data because of their association with disease progressing in various kinds of laboratory animals. Screening of Helicobacter species is particularly desi...

    Authors: Sunhwa Hong, Yungho Chung, Won-Guk Kang, Yeon-Shik Choi and Okjin Kim

    Citation: Laboratory Animal Research 2015 31:3102086

    Content type: OriginalPaper

    Published on:

  27. Streptococcus pneumoniae is a major human pathogen that is involved in community-acquired pneumonia. Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine that activates immune responses against infe...

    Authors: Dong-Gu Jeong, Jin-Hee Seo, Seung-Ho Heo, Yang-Kyu Choi and Eui-Suk Jeong

    Citation: Laboratory Animal Research 2015 31:3102078

    Content type: OriginalPaper

    Published on:

  28. Gastrodia elata (GE) is traditionally used for treatment of various disorders including neurodegenerative diseases such as Alzheimer’s disease. To investigate the neuroprotective effect of GE, amyloid-β peptide (...

    Authors: Young-Mi Park, Bong-Gun Lee, Sang-Hoon Park, Hong-Geun Oh, Yang-Gyu Kang, Ok-Jin Kim, Lee-Seong Kwon, Yong-Phill Kim, Min-Hyu Choi, Yong-Seob Jeong, Jisun Oh and Hak-Yong Lee

    Citation: Laboratory Animal Research 2015 31:3102069

    Content type: OriginalPaper

    Published on:

  29. Coronary artery disease is a common occurrence in human, and causes enormous social cost. Poncirus fructus (PF), the dried immature fruits of Poncirus trifoliata Rafinesquem, is used in the treatment of womb cont...

    Authors: Dong-Jun Yu, Jin-Hong Jun, Tae-Jun Kim, Dong-Kyun Suh, Dong-ho Youn and Tae-Wan Kim

    Citation: Laboratory Animal Research 2015 31:3101033

    Content type: OriginalPaper

    Published on:

  30. Since scalp hair loss has increased recently even in young people, seriously affecting individual’s quality of life, the hair growth-stimulating effects of Laminaria japonica extract (LJE) and Cistanche tubulosa ...

    Authors: Kyungha Shin, Tae-Su Kim, Jangbeen Kyung, Dajeong Kim, Dongsun Park, Ehn-Kyoung Choi, Sung-Pyo Lee, Woong-Suk Yang, Myung-Hwa Kang and Yun-Bae Kim

    Citation: Laboratory Animal Research 2015 31:3101024

    Content type: OriginalPaper

    Published on:

  31. Some biological effects of Red Liriope platyphylla (RLP) on various chronic diseases including Alzheimer’s disease, diabetes and obesity were suggested after a report of the production from Liriope platyphylla (L...

    Authors: Young-Ju Lee, Eun-Kyoung Koh, Ji-Eun Kim, Jun Go, Sung-Hwa Song, Ji-Eun Seong, Hong-Joo Son, Byeong-Cheol Kang and Dae-Youn Hwang

    Citation: Laboratory Animal Research 2015 31:3101013

    Content type: OriginalPaper

    Published on:

  32. Helicobacter pylori-eliminating effects of FEMY-R7, composed of Laminaria japonica and Oenothera biennis extracts, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intrag...

    Authors: Tae-Su Kim, Kyungha Shin, Joseph H. Jeon, Ehn-Kyoung Choi, Youngjin Choi, Sung-Pyo Lee, Yoon-Bok Lee and Yun-Bae Kim

    Citation: Laboratory Animal Research 2015 31:3101007

    Content type: OriginalPaper

    Published on:

  33. The leptin receptor-deficient db/db mouse is a rodent model of type 2 diabetes and obesity. Diabetes in db/db mice shows an age-dependent progression, with early insulin resistance followed by an insulin secretor...

    Authors: Hye-Min Choi, Hae Rim Kim, Eun-Kyoung Kim, Yong Sub Byun, Young-Suk Won, Won-Ki Yoon, Hyoung-Chin Kim, Jong-Goo Kang and Ki-Hoan Nam

    Citation: Laboratory Animal Research 2015 31:3101001

    Content type: OriginalPaper

    Published on:

  34. Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) can occur in cancer patients after irradiation. In this study, we characterized the clinical and histopathological features ...

    Authors: Joong Sun Kim, Won Seok Jang, Min Ji Bae, Sunhoo Park and Seung Sook Lee

    Citation: Laboratory Animal Research 2015 31:7

    Content type: Letter

    Published on:

  35. Curcumin exerts a protective effect in cerebral ischemia through its anti-oxidant and anti-inflammatory activities. γ-enolase is a glycolytic enzyme expressed in neurons that is known to exerts a neuroprotecti...

    Authors: Sang-Ah Gim, So-Ra Lee, Fawad-Ali Shah and Phil-Ok Koh

    Citation: Laboratory Animal Research 2015 31:6

    Content type: Letter

    Published on:

  36. Inflammation has recently been implicated in cancer formation and progression. As tissue transglutaminase (TG2) has been associated with both inflammatory signaling and tumor cell behavior, we propose that TG2...

    Authors: Keunhee Oh, Hyeong-Gon Moon, Dong-Sup Lee and Young-Bok Yoo

    Citation: Laboratory Animal Research 2015 31:5

    Content type: OriginalPaper

    Published on:

  37. The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the foll...

    Authors: Azam Najar, Mohammadjavad Fridoni, Fatemesadat Rezaei, Saba Bayat and Mohammad Bayat

    Citation: Laboratory Animal Research 2015 31:4

    Content type: OriginalPaper

    Published on:

  38. Procedures involving complex surgical techniques in rats, such as placement of abdominal aortic graft require extended duration of surgical anesthesia, which often can be achieved by repeated administrations o...

    Authors: Arun H. S. Kumar and Anthony J. P. Clover

    Citation: Laboratory Animal Research 2015 31:3

    Content type: OriginalPaper

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  39. Genetic background in animal models is an intrinsic research variable in biomedical research. Although inbred strains offer genetic uniformity, the outbred stocks, known for genetic variability are often used ...

    Authors: Marcia Brower, Martha Grace, Catherine M. Kotz and Vijay Koya

    Citation: Laboratory Animal Research 2015 31:2

    Content type: OriginalPaper

    Published on:

  40. The common marmoset (Callithrix jacchus) is a small-bodied, popular New World monkey and is used widely in reproductive biology, neuroscience, and drug development, due to its comparative ease of handling, high r...

    Authors: Jun-Won Yun, Jae-Bum Ahn and Byeong-Cheol Kang

    Citation: Laboratory Animal Research 2015 31:1

    Content type: Review

    Published on:

Affiliated with


  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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