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  1. Quercetin, a natural flavonoid, copiously exists in vegetable, fruits and tea. Quercetin is beneficial to neurodegenerative disorders via its strong anti-oxidant and anti-inflammatory activities. γ-Enolase is ...

    Authors: Seong-Jun Jeon, Myeong-Ok Kim, Fawad Ali-Shah and Phil-Ok Koh
    Citation: Laboratory Animal Research 2018 33:3304308
    Content type: OriginalPaper Published on:

  2. A correlation between endoplasmic reticulum (ER) stress and laxative effects was first reported in a constipation model treated with an aqueous extract of Liriope platyphylla (AEtLP) roots. To investigate the cor...

    Authors: Ji Eun Kim, Bo Ram Song, Woo Bin Yun, Jun Young Choi, Jin Ju Park, Mi Rim Lee and Dae Youn Hwang
    Citation: Laboratory Animal Research 2018 33:3304298
    Content type: OriginalPaper Published on:

  3. Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its ...

    Authors: Jong-Hwan Kim, Eun-Young Cho, Euna Kwon, Woo-Ho Kim, Jin-Sung Park, Yong-Soon Lee, Jun-Won Yun and Byeong-Cheol Kang
    Citation: Laboratory Animal Research 2018 33:3304291
    Content type: OriginalPaper Published on:

  4. In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on dgalactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (int...

    Authors: Kwon Young Lee, Hyo Young Jung, Dae Young Yoo, Woosuk Kim, Jong Whi Kim, Hyun Jung Kwon, Dae Won Kim, Yeo Sung Yoon, In Koo Hwang and Jung Hoon Choi
    Citation: Laboratory Animal Research 2017 33:3304283
    Content type: OriginalPaper Published on:

  5. This paper reports a case of super pregnancy in a BALB/c mouse pregnant with 30 pups following induction of superovulation using a PMSG-hCG protocol. Superovulation was induced in 10 mice by injecting 5 IU PMS...

    Authors: Hanieh Vaseghi, Asghar Mogheiseh, Masood Sepehrimanesh, Mojtaba Kafi and Mohammad Hossein Nooranizadeh
    Citation: Laboratory Animal Research 2017 33:3303280
    Content type: Case Report Published on:

  6. Mulberry (Morus alba) leaves are known to have therapeutic effects on lipid metabolism including lipogenesis, lipolysis and hyperlipidemia. However, novel compounds with strong lipolytic ability among 27 extracts...

    Authors: Mi Rim Lee, Ji Eun Kim, Woo Bin Yun, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Whan Choi, Kyung Mi Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2017 33:3303270
    Content type: OriginalPaper Published on:

  7. Successful male germ cell transplantation requires depletion of the host germ cells to allow efficient colonization of the donor spermatogonial stem cells. Although a sterilizing drug, busulfan, is commonly us...

    Authors: Tai-Young Hur, Seung-Hoon Lee, Sun-A Ock, Hyuk Song, Hyun-Jung Park, Ran Lee, Si-Heung Sung, Hyunjhung Jhun and Won-Young Lee
    Citation: Laboratory Animal Research 2017 33:3303264
    Content type: OriginalPaper Published on:

  9. Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intak...

    Authors: So-Hyeon Bok, Seung Sik Cho, Chun-Sik Bae, Dae-Hun Park and Kyung-Mok Park
    Citation: Laboratory Animal Research 2017 33:3303251
    Content type: OriginalPaper Published on:

  11. Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (...

    Authors: Ji Hyeon Ahn, Tae-Kyeong Lee, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Il Jun Kang, Young Joo Lee, Moo-Ho Won and Choong-Hyun Lee
    Citation: Laboratory Animal Research 2017 33:3303237
    Content type: OriginalPaper Published on:

  12. Among three representative species of Angelica found in Asian countries, including Korea, China, and Japan, Angelica acutiloba (AA) has been used as traditional herbal medicine with antitumor, antiinflammatory, a...

    Authors: Jun-Won Yun, Yun-Soon Kim, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Hyeon Hoe Kim, Jeong-Hwan Che and Byeong-Cheol Kang
    Citation: Laboratory Animal Research 2017 33:3303231
    Content type: OriginalPaper Published on:

  13. Angelica acutiloba (AA), a Japanese species of Danggui, has been used worldwide as a traditional herbal medicine with several bioactivities including anti-diabetic, anti-allergic, anti-inflammatory, anti-tumor, a...

    Authors: Jun-Won Yun, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Yun-Soon Kim, In Ae Park, Hyeon Hoe Kim, Jeong-Hwan Che and Byeong-Cheol Kang
    Citation: Laboratory Animal Research 2017 33:3303223
    Content type: OriginalPaper Published on:

  14. This study aims to evaluate early changes in retinal structure and BMP2 expression in the retina and crystalline lens by comparing streptozotocin-induced diabetic pigs and normal control group pigs.

    Authors: Jae Seung Jeong, Woon-Kyu Lee, Yeon Sung Moon and Na Rae Kim
    Citation: Laboratory Animal Research 2017 33:3303216
    Content type: OriginalPaper Published on:

  15. Artemisia argyi is used as a health supplement, tea, and food source in Korea. This study aimed to evaluate the effect of Artemisia argyi (AA) and its active compound, dehydromatricarin A (DA), on the attenuation...

    Authors: Na-Rae Shin, Sung-Hyeuk Park, Je-Won Ko, Hyung-Won Ryu, Seong-Hun Jeong, Jong-Choon Kim, Dong-Ho Shin, Hoon-Sang Lee and In-Sik Shin
    Citation: Laboratory Animal Research 2017 33:3303209
    Content type: OriginalPaper Published on:

  17. Pet turtles are well-known to harbor an array of bacterial pathogens which can cause zoonotic infections in humans as well as opportunistic infections in the turtles itself. Essential oils are the natural plan...

    Authors: Sabrina Hossain, Honghoi Heo, B. C. J. De Silva, S. H. M. P. Wimalasena, H. N. K. S. Pathirana and Gang-Joon Heo
    Citation: Laboratory Animal Research 2017 33:3303195
    Content type: OriginalPaper Published on:

  18. Korl:ICR mice, established by the Korean National Institute of Food and Drug Safety Evaluation (NIFDS), are characterized based on their genetic variation, response to gastric injury, and response to constipat...

    Authors: Ji Eun Sung, Ji Eun Kim, Hyun Ah Lee, Woo Bin Yun, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Suk Jung, Kil Soo Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2017 33:3302187
    Content type: OriginalPaper Published on:

  19. C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neu...

    Authors: Woo Bin Yun, Hye Ryeong Kim, Ji Eun Kim, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Young Suk Jung, Hyun Keun Song, Joon Young Cho, Kil Soo Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2017 33:3302179
    Content type: OriginalPaper Published on:

  20. Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual ten...

    Authors: Ji Eun Kim, Jung Hoon Nam, Joon Young Cho, Kil Soo Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2017 33:3302171
    Content type: OriginalPaper Published on:

  21. Doxorubicin is a widely used chemotherapeutic agents and is now part of standard therapeutic regimens for a variety of cancers (eg, hematopoietic malignancies and advanced solid tumors of the breast, ovary, th...

    Authors: Sou Hyun Kim, Keuk-Jun Kim, Joung-Hee Kim, Jae-Hwan Kwak, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung
    Citation: Laboratory Animal Research 2017 33:3302165
    Content type: OriginalPaper Published on:

  22. Non-alcoholic fatty liver disease (NAFLD) is believed to be the most prevalent liver disease worldwide and a major cause of chronic liver injury. It is characterized by lipid accumulation in the absence of sig...

    Authors: Sou Hyun Kim, Yong Lim, Ju Bin Park, Jae-Hwan Kwak, Keuk-Jun Kim, Joung-Hee Kim, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung
    Citation: Laboratory Animal Research 2017 33:3302157
    Content type: OriginalPaper Published on:

  23. This study was conducted to compare the multiple low-dose streptozotocin (MLDS)-induced diabetic patterns of Korl:ICR, A:ICR, and B:ICR mice obtained from three different sources. Six-week-old male ICR mice we...

    Authors: Do Yeon Lee, Myeong Hwan Kim, Hye Rin Suh, Young Suk Jung, Dae Youn Hwang and Kil Soo Kim
    Citation: Laboratory Animal Research 2017 33:3302150
    Content type: OriginalPaper Published on:

  24. Animal model, as an indispensable tool for scientific purposes of biomedical researches and clinical application, is a commonly used in various researches. Regarding to this, it is necessary to establish the m...

    Authors: Dong-Ju Hwang, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang and Joon Young Cho
    Citation: Laboratory Animal Research 2017 33:3302140
    Content type: OriginalPaper Published on:

  25. Adaptive immunity is a type of immune response mediated by T and B cells, and is important response for immune response amplification and memory. In this study, the adaptive immunologic properties of C57BL/6NK...

    Authors: Hye Ryeong Kim, Jun Young Choi, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang and Hyun Keun Song
    Citation: Laboratory Animal Research 2017 33:3302132
    Content type: OriginalPaper Published on:

  26. Inbred mice, a systematically developed homogeneous animal, have been developed to maintain experimental reproducibility and to minimize experimental variables in animal-based studies. In particular, C57BL/6 m...

    Authors: Jun Young Choi, Hye Ryeong Kim, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang and Hyun Keun Song
    Citation: Laboratory Animal Research 2017 33:3302124
    Content type: OriginalPaper Published on:

  27. Inbred mice are an essential animal strain for research as they can improve the reproducibility and reliability of study results. The establishment of new inbred lines is continuing, and new inbred lines are b...

    Authors: Hyun Keun Song and Dae Youn Hwang
    Citation: Laboratory Animal Research 2017 33:3302119
    Content type: Review Published on:

  28. Glucose is essential for testicular function; the uptake of carbohydrate-derived glucose by cells is mediated by glucose transporters (GLUTs). In the present study, we investigated the activity of GLUT1 and GL...

    Authors: Kyu Ri Hahn, Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Yang Hee Kim, Young Kwang Jo, Geon A. Kim, Jin Young Chung, Jung Hoon Choi, In Koo Hwang, Goo Jang and Yeo Sung Yoon
    Citation: Laboratory Animal Research 2017 33:3302114
    Content type: Case Report Published on:

  29. Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, b...

    Authors: Young-Hwan Ban, Yeseul Cha, Jieun Choi, Eun Suk An, Ji Young Lee, Nu Ry Han, Da Woom Seo, Gooyoung Jung, Da-Hye Jeong, Man Hee Rhee, Ehn-Kyoung Choi and Yun-Bae Kim
    Citation: Laboratory Animal Research 2017 33:3302105
    Content type: OriginalPaper Published on:

  31. The objective of this study was to determine the effect of ionizing radiation (IR) exposure of parents on carcinogenesis of the next generation focusing on the epigenetic perspective to clarify the relationshi...

    Authors: Lan Li, Jong-Hyun Kim, Hee-Tae Park, Jae-Hoon Lee, Min-Koo Park, Ji-Won Lee, Jeong-Chan Lee and Min-Jae Lee
    Citation: Laboratory Animal Research 2017 33:3302092
    Content type: OriginalPaper Published on:

  32. The usage of essential oils as antimicrobial agents is gaining attention. Besides, pet turtles were known to harbor a range of pathogenic bacteria while the turtle keeping is a growing trend worldwide.The curr...

    Authors: B. C. J. De Silva, Won-Gi Jung, Sabrina Hossain, S. H. M. P. Wimalasena, H. N. K. S. Pathirana and Gang-Joon Heo
    Citation: Laboratory Animal Research 2017 33:3302084
    Content type: OriginalPaper Published on:

  33. Chronic obstructive pulmonary diseases (COPD) is an important disease featured as intense inflammation, protease imbalance, and air flow limitation and mainly induced by cigarette smoke (CS). In present study,...

    Authors: Je-Won Ko, Na-Rae Shin, Sung-Hyeuk Park, Joong-Sun Kim, Young-Kwon Cho, Jong-Choon Kim, In-Sik Shin and Dong-Ho Shin
    Citation: Laboratory Animal Research 2017 33:3302076
    Content type: OriginalPaper Published on:

  34. The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading unde...

    Authors: Shikha Yadav, Inderjeet Yadav, Kunal Pratap, Pradeep Kumar Tiwari and Vijay Pal Singh
    Citation: Laboratory Animal Research 2017 33:3302068
    Content type: OriginalPaper Published on:

  35. The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines ...

    Authors: Ji Eun Sung, Jun Young Choi, Ji Eun Kim, Hyun Ah Lee, Woo Bin Yun, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Dong Seob Kim, Chung Yeoul Lee, Hee Seob Lee, Yong Lim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2017 33:3302057
    Content type: OriginalPaper Published on:

  36. Turtle-borne Salmonella enterica owns significance as a leading cause in human salmonellosis. The current study aimed to determine the quinolone susceptibility and the genetic characteristics of 21 strains of S. ...

    Authors: B. C. J. De Silva, Sabrina Hossain, S. H. M. P. Wimalasena, H. N. K. S. Pathirana, Mitchell Wendt and Gang-Joon Heo
    Citation: Laboratory Animal Research 2017 33:3302049
    Content type: OriginalPaper Published on:

  37. HemoHIM, herbal preparation has designed for immune system recovery. We investigated the antiinflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulm...

    Authors: Na-Rae Shin, Sung-Ho Kim, Je-Won Ko, Sung-Hyeuk Park, In-Chul Lee, Jung-Min Ryu, Jong-Choon Kim and In-Sik Shin
    Citation: Laboratory Animal Research 2017 33:3301040
    Content type: OriginalPaper Published on:

  38. The purpose of this study was to investigate the immunomodulatory activity of ice plant (Mesembryanthemum crystallinum) extract (IPE) in vitro and in vivo. Raji (a human B cell line) and Jurkat (a human T cell li...

    Authors: Joo-Hee Choi, Sung-Gang Jo, Seoung-Ki Jung, Woo-Tae Park, Keun-Young Kim, Yong-Wook Park and Jong-Hwan Park
    Citation: Laboratory Animal Research 2017 33:3301032
    Content type: OriginalPaper Published on:

  39. The study was performed to see the effects of coenzyme Q10 (CoQ10) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats w...

    Authors: Min-Hae Song, Ha-Na Kim, Yong Lim and In-Surk Jang
    Citation: Laboratory Animal Research 2017 33:3301024
    Content type: OriginalPaper Published on:

  40. Previous studies report positive effects of pentoxifylline (PTX) alone or in combination with other drugs on some pathologic bone diseases as well as an ability to accelerate osteogensis and fracture healing i...

    Authors: Mohammad Mahdi Vashghani Farahani, Reza Ahadi, Mohammadamin Abdollahifar and Mohammad Bayat
    Citation: Laboratory Animal Research 2017 33:3301015
    Content type: OriginalPaper Published on:

  41. Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology, oncology, infect...

    Authors: Hye-Jun Shin, Young Min Cho, Hee Jung Shin, Hae Deun Kim, Kyung Min Choi, Mi Gyeong Kim, Hyoung Doo Shin and Myeon-Woo Chung
    Citation: Laboratory Animal Research 2017 33:3301008
    Content type: OriginalPaper Published on:

  42. Circling mouse (C57BL/6J-cir/cir) deleted the transmembrane inner ear (Tmie) gene is an animal model for human non-syndromic recessive deafness, DFNB6. In circling mouse, hair cells in the cochlea have degenerate...

    Authors: Yoo Yeon Kim, Hajin Nam, Harry Jung, Boyoung Kim and Jun Gyo Suh
    Citation: Laboratory Animal Research 2017 33:3301001
    Content type: OriginalPaper Published on:

  43. Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering ...

    Authors: Yun-Jung Choi, Hye-Jin Park, Chul-Ho Sohn, Kyeong Cheon Jung, Seong Hoe Park and Jae-Il Lee
    Citation: Laboratory Animal Research 2016 32:3204267
    Content type: Case Report Published on:

  44. Transplantation of spermatogonial stem cells (SSCs) in experimental animal models has been used to study germ line stem cell biology and to produce transgenic animals. The species-specific recipient model prep...

    Authors: Won-Young Lee, Ran Lee, Hyuk Song, Tai-Young Hur, Seunghoon Lee, Jiyun Ahn and Hyunjhung Jhun
    Citation: Laboratory Animal Research 2016 32:3204257
    Content type: OriginalPaper Published on:

  45. Alzheimer’s disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of hum...

    Authors: Woo Bin Yun, Jin Ju Park, Ji Eun Kim, Ji Eun Sung, Hyun Ah Lee, Jae Ho Lee, Chang Jun Bae and Dae Youn Hwang
    Citation: Laboratory Animal Research 2016 32:3204249
    Content type: OriginalPaper Published on:

  47. Our research sought to characterize the phylogeny of Pseudomonas aeruginosa isolated from pet Chinese stripe-necked turtles (Ocadia sinensis) to better understand its evolutionary relation to other isolates and i...

    Authors: Mitchell Wendt and Gang-Joon Heo
    Citation: Laboratory Animal Research 2016 32:3204208
    Content type: OriginalPaper Published on:

  48. This study investigated the protective effects of diallyl disulfide (DADS) against acetaminophen (AAP)-induced acute renal injury in male rats. We also investigated the effects of DADS on kidney injury molecul...

    Authors: Jin-Young Shin, Ji-Hee Han, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, Tae-Yang Jung, Hyun-A Kim, Sung-Hwan Kim, In-Sik Shin and Jong-Choon Kim
    Citation: Laboratory Animal Research 2016 32:3204200
    Content type: OriginalPaper Published on:

  49. Dynamin-like protein I (DLP-1) is an important mitochondrial fission and fusion protein that is associated with apoptotic cell death in neurodegenerative diseases. In this study, we investigated DLP-1 expressi...

    Authors: Ah-Ram Jang and Phil-Ok Koh
    Citation: Laboratory Animal Research 2016 32:3204194
    Content type: OriginalPaper Published on:

  50. Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [po...

    Authors: Yawon Hwang and Gonhyung Kim
    Citation: Laboratory Animal Research 2016 32:3204181
    Content type: OriginalPaper Published on:
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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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Laboratory Animal Research

ISSN: 2233-7660