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  1. Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual ten...

    Authors: Ji Eun Kim, Jung Hoon Nam, Joon Young Cho, Kil Soo Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2017 33:3302171
    Content type: OriginalPaper Published on:

  2. Doxorubicin is a widely used chemotherapeutic agents and is now part of standard therapeutic regimens for a variety of cancers (eg, hematopoietic malignancies and advanced solid tumors of the breast, ovary, th...

    Authors: Sou Hyun Kim, Keuk-Jun Kim, Joung-Hee Kim, Jae-Hwan Kwak, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung
    Citation: Laboratory Animal Research 2017 33:3302165
    Content type: OriginalPaper Published on:

  3. Non-alcoholic fatty liver disease (NAFLD) is believed to be the most prevalent liver disease worldwide and a major cause of chronic liver injury. It is characterized by lipid accumulation in the absence of sig...

    Authors: Sou Hyun Kim, Yong Lim, Ju Bin Park, Jae-Hwan Kwak, Keuk-Jun Kim, Joung-Hee Kim, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung
    Citation: Laboratory Animal Research 2017 33:3302157
    Content type: OriginalPaper Published on:

  4. Animal model, as an indispensable tool for scientific purposes of biomedical researches and clinical application, is a commonly used in various researches. Regarding to this, it is necessary to establish the m...

    Authors: Dong-Ju Hwang, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang and Joon Young Cho
    Citation: Laboratory Animal Research 2017 33:3302140
    Content type: OriginalPaper Published on:

  5. Adaptive immunity is a type of immune response mediated by T and B cells, and is important response for immune response amplification and memory. In this study, the adaptive immunologic properties of C57BL/6NK...

    Authors: Hye Ryeong Kim, Jun Young Choi, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang and Hyun Keun Song
    Citation: Laboratory Animal Research 2017 33:3302132
    Content type: OriginalPaper Published on:

  6. Inbred mice, a systematically developed homogeneous animal, have been developed to maintain experimental reproducibility and to minimize experimental variables in animal-based studies. In particular, C57BL/6 m...

    Authors: Jun Young Choi, Hye Ryeong Kim, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang and Hyun Keun Song
    Citation: Laboratory Animal Research 2017 33:3302124
    Content type: OriginalPaper Published on:

  7. Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, b...

    Authors: Young-Hwan Ban, Yeseul Cha, Jieun Choi, Eun Suk An, Ji Young Lee, Nu Ry Han, Da Woom Seo, Gooyoung Jung, Da-Hye Jeong, Man Hee Rhee, Ehn-Kyoung Choi and Yun-Bae Kim
    Citation: Laboratory Animal Research 2017 33:3302105
    Content type: OriginalPaper Published on:

  8. The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading unde...

    Authors: Shikha Yadav, Inderjeet Yadav, Kunal Pratap, Pradeep Kumar Tiwari and Vijay Pal Singh
    Citation: Laboratory Animal Research 2017 33:3302068
    Content type: OriginalPaper Published on:

  9. The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines ...

    Authors: Ji Eun Sung, Jun Young Choi, Ji Eun Kim, Hyun Ah Lee, Woo Bin Yun, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Dong Seob Kim, Chung Yeoul Lee, Hee Seob Lee, Yong Lim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2017 33:3302057
    Content type: OriginalPaper Published on:

  10. HemoHIM, herbal preparation has designed for immune system recovery. We investigated the antiinflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulm...

    Authors: Na-Rae Shin, Sung-Ho Kim, Je-Won Ko, Sung-Hyeuk Park, In-Chul Lee, Jung-Min Ryu, Jong-Choon Kim and In-Sik Shin
    Citation: Laboratory Animal Research 2017 33:3301040
    Content type: OriginalPaper Published on:

  11. The purpose of this study was to investigate the immunomodulatory activity of ice plant (Mesembryanthemum crystallinum) extract (IPE) in vitro and in vivo. Raji (a human B cell line) and Jurkat (a human T cell li...

    Authors: Joo-Hee Choi, Sung-Gang Jo, Seoung-Ki Jung, Woo-Tae Park, Keun-Young Kim, Yong-Wook Park and Jong-Hwan Park
    Citation: Laboratory Animal Research 2017 33:3301032
    Content type: OriginalPaper Published on:

  12. The study was performed to see the effects of coenzyme Q10 (CoQ10) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats w...

    Authors: Min-Hae Song, Ha-Na Kim, Yong Lim and In-Surk Jang
    Citation: Laboratory Animal Research 2017 33:3301024
    Content type: OriginalPaper Published on:

  13. Previous studies report positive effects of pentoxifylline (PTX) alone or in combination with other drugs on some pathologic bone diseases as well as an ability to accelerate osteogensis and fracture healing i...

    Authors: Mohammad Mahdi Vashghani Farahani, Reza Ahadi, Mohammadamin Abdollahifar and Mohammad Bayat
    Citation: Laboratory Animal Research 2017 33:3301015
    Content type: OriginalPaper Published on:

  14. Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology, oncology, infect...

    Authors: Hye-Jun Shin, Young Min Cho, Hee Jung Shin, Hae Deun Kim, Kyung Min Choi, Mi Gyeong Kim, Hyoung Doo Shin and Myeon-Woo Chung
    Citation: Laboratory Animal Research 2017 33:3301008
    Content type: OriginalPaper Published on:

  15. Circling mouse (C57BL/6J-cir/cir) deleted the transmembrane inner ear (Tmie) gene is an animal model for human non-syndromic recessive deafness, DFNB6. In circling mouse, hair cells in the cochlea have degenerate...

    Authors: Yoo Yeon Kim, Hajin Nam, Harry Jung, Boyoung Kim and Jun Gyo Suh
    Citation: Laboratory Animal Research 2017 33:3301001
    Content type: OriginalPaper Published on:

  16. Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering ...

    Authors: Yun-Jung Choi, Hye-Jin Park, Chul-Ho Sohn, Kyeong Cheon Jung, Seong Hoe Park and Jae-Il Lee
    Citation: Laboratory Animal Research 2016 32:3204267
    Content type: Case Report Published on:

  17. Transplantation of spermatogonial stem cells (SSCs) in experimental animal models has been used to study germ line stem cell biology and to produce transgenic animals. The species-specific recipient model prep...

    Authors: Won-Young Lee, Ran Lee, Hyuk Song, Tai-Young Hur, Seunghoon Lee, Jiyun Ahn and Hyunjhung Jhun
    Citation: Laboratory Animal Research 2016 32:3204257
    Content type: OriginalPaper Published on:

  18. Alzheimer’s disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of hum...

    Authors: Woo Bin Yun, Jin Ju Park, Ji Eun Kim, Ji Eun Sung, Hyun Ah Lee, Jae Ho Lee, Chang Jun Bae and Dae Youn Hwang
    Citation: Laboratory Animal Research 2016 32:3204249
    Content type: OriginalPaper Published on:

  20. Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects and the action mechanism of drugs against this disease. ICR mice were selected to produce ...

    Authors: Ji Eun Kim, Woo Bin Yun, Ji Eun Sung, Hyun Ah Lee, Jun Young Choi, Yeon Shik Choi, Young Suk Jung, Kil Soo Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2016 32:3204231
    Content type: OriginalPaper Published on:

  21. We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationsh...

    Authors: Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Dae Won Kim, Jung Hoon Choi, Jin Young Chung, Moo-Ho Won, Yeo Sung Yoon and In Koo Hwang
    Citation: Laboratory Animal Research 2016 32:3204224
    Content type: OriginalPaper Published on:

  22. This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats w...

    Authors: Myeong-Hwan Kim, Eun-Jin Lee, Jeong-Mu Cheon, Ki-Jun Nam, Tae-Ho Oh and Kil-Soo Kim
    Citation: Laboratory Animal Research 2016 32:3204217
    Content type: OriginalPaper Published on:

  23. Our research sought to characterize the phylogeny of Pseudomonas aeruginosa isolated from pet Chinese stripe-necked turtles (Ocadia sinensis) to better understand its evolutionary relation to other isolates and i...

    Authors: Mitchell Wendt and Gang-Joon Heo
    Citation: Laboratory Animal Research 2016 32:3204208
    Content type: OriginalPaper Published on:

  24. This study investigated the protective effects of diallyl disulfide (DADS) against acetaminophen (AAP)-induced acute renal injury in male rats. We also investigated the effects of DADS on kidney injury molecul...

    Authors: Jin-Young Shin, Ji-Hee Han, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, Tae-Yang Jung, Hyun-A Kim, Sung-Hwan Kim, In-Sik Shin and Jong-Choon Kim
    Citation: Laboratory Animal Research 2016 32:3204200
    Content type: OriginalPaper Published on:

  25. Dynamin-like protein I (DLP-1) is an important mitochondrial fission and fusion protein that is associated with apoptotic cell death in neurodegenerative diseases. In this study, we investigated DLP-1 expressi...

    Authors: Ah-Ram Jang and Phil-Ok Koh
    Citation: Laboratory Animal Research 2016 32:3204194
    Content type: OriginalPaper Published on:

  26. The purpose of this study was to delineate the various factors that affect the growth characteristics of human cancer xenografts in nude mice and to reveal the relationship between the growth characteristics a...

    Authors: Ji Young Lee, Mi-Sook Kim, Eun Ho Kim, Namhyun Chung and Youn Kyoung Jeong
    Citation: Laboratory Animal Research 2016 32:3204187
    Content type: OriginalPaper Published on:

  27. Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMAPMMA [po...

    Authors: Yawon Hwang and Gonhyung Kim
    Citation: Laboratory Animal Research 2016 32:3204181
    Content type: OriginalPaper Published on:

  28. Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD contai...

    Authors: Yeseul Cha, Ja Young Jang, Young-Hwan Ban, Haiyu Guo, Kyungha Shin, Tae-Su Kim, Sung-Pyo Lee, Jieun Choi, Eun-Suk An, Da-Woom Seo, Jung-Min Yon, Ehn-Kyoung Choi and Yun-Bae Kim
    Citation: Laboratory Animal Research 2016 32:3203179
    Content type: OriginalPaper Published on:

  29. Pet turtles are known as a source of Salmonella infection to humans when handled in captivity. Thirty four turtles purchased from pet shops and online markets in Korea were examined to determine whether the turtl...

    Authors: Du-San Back, Gee-Wook Shin, Mitchell Wendt and Gang-Joon Heo
    Citation: Laboratory Animal Research 2016 32:3203166
    Content type: OriginalPaper Published on:

  30. The approach and novelty of this scientific work was to formulate the appropriate Streptozotocin (STZ) and Alloxan dosage in different routes of administration to imply minimum mortality rate and high incidenc...

    Authors: Ataroalsadat Mostafavinia, Abdodlah Amini, Seyed Kamran Ghorishi, Ramin Pouriran and Mohammad Bayat
    Citation: Laboratory Animal Research 2016 32:3203160
    Content type: OriginalPaper Published on:

  31. Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. ...

    Authors: Seungho Choi, Jong-Kyu Woo, Yeong-Su Jang, Ju-Hee Kang, Jung-Eun Jang, Tae-Hoo Yi, Sang-Yong Park, Sun-Yeou Kim, Yeo-Sung Yoon and Seung Hyun Oh
    Citation: Laboratory Animal Research 2016 32:3203151
    Content type: OriginalPaper Published on:

  32. Dendrobium moniliforme (L.) Sw., an herb of the Orchidaceae family, has long been used in traditional medicine to strengthen bones, nourish the stomach, and promote the production of bodily fluid. Recently, polys...

    Authors: Mu-Jin Lee, Ho-Kyung Jung, Min-Suk Kim, Ji-Hun Jang, Mi-Ok Sim, Tea-Mook Kim, Ho Park, Byung-Kwan Ahn, Hyun-Woo Cho, Jung-Hee Cho, Won-Seok Jung and Jong-Choon Kim
    Citation: Laboratory Animal Research 2016 32:3203144
    Content type: OriginalPaper Published on:

  33. The aim of this study was to examine the therapeutic potential of sulfasalazine and prednisolone in a mouse collagen antibody-induced arthritis (CAIA) model. Twenty-five male BALB/c mice were randomly divided ...

    Authors: Joo Hye Sim, Won Kil Lee, Yun Seok Lee and Jin Seok Kang
    Citation: Laboratory Animal Research 2016 32:3203135
    Content type: OriginalPaper Published on:

  35. We designed 4 primers for amplification of allelespecific PCR products from leptin receptor mutant and normal alleles using primer design web service for tetraprimer ARMS-PCR (Figure 1) i.e., Lepr-forward oute...

    Authors: Harry Jung, Hajin Nam and Jun-Gyo Suh
    Citation: Laboratory Animal Research 2016 32:3202133
    Content type: Erratum Published on:

    The original article was published in Laboratory Animal Research 2016 32:Art9

  36. Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferati...

    Authors: Hyo Young Jung, Dae Young Yoo, Young Kwang Jo, Geon A. Kim, Jin Young Chung, Jung Hoon Choi, Goo Jang and In Koo Hwang
    Citation: Laboratory Animal Research 2016 32:3202128
    Content type: Case Report Published on:

  38. Whereas increasing concerns about radiation exposure to nuclear disasters or side effects of anticancer radiotherapy, relatively little research for radiation damages or remedy has been done. The purpose of th...

    Authors: Seung-Hyun Ryu, Jong-Hyung Park, Eui-Suk Jeong, Soo-Young Choi, Seung-Hoon Ham, Jin-Il Park, Hee-Yeon Jeon, Jun-Young Kim, Ran-Ji Yoo, Yong-Jin Lee, Sang-Keun Woo and Yang-Kyu Choi
    Citation: Laboratory Animal Research 2016 32:3202116
    Content type: OriginalPaper Published on:

  39. To investigate the beneficial effects of diosgenin (DC) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were measured ...

    Authors: Eun-Kyoung Koh, Woo-Bin Yun, Ji-Eun Kim, Sung-Hwa Song, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Seung-Wan Jee, Chang-Joon Bae and Dae-Youn Hwang
    Citation: Laboratory Animal Research 2016 32:3202105
    Content type: OriginalPaper Published on:

  40. Helicobacter pylori colonizes the gastric mucosa of about half of the world’s population, causing chronic gastritis and gastric cancer. An increasing emergence of antibiotic-resistant H. pylori arouses demand on ...

    Authors: Dong-Jae Kim, Min-Jung Kang, Jin-A Choi, Dae-Seung Na, Jin-Beom Kim, Chun-Soo Na and Jong-Hwan Park
    Citation: Laboratory Animal Research 2016 32:3202099
    Content type: OriginalPaper Published on:

  41. The aim of this study is to investigate the potential of anti-osteoarthritis effects on egg white-chalcanthite (EC), purple bamboo salts (PBS), and a mixture of EC and PBS (EC+PBS). EC is a mixture of egg whit...

    Authors: Tae-Hee Lee, Hyun-kyung Song, Ja-Young Jang, Dong-Yoon Kim, Hyun-Kyung Park, Eun-A Choi and Beom-Seok Han
    Citation: Laboratory Animal Research 2016 32:3202091
    Content type: OriginalPaper Published on:

  42. The antibacterial activities of the essential oil of Eucalyptus globulus (EOEG) was determined against 7 fish pathogenic bacteria (Edwardsiella tarda, Streptococcus iniae, S. parauberis, Lactococcus garviae, Vibr...

    Authors: Joon-Woo Park, Mitchell Wendt and Gang-Joon Heo
    Citation: Laboratory Animal Research 2016 32:3202087
    Content type: OriginalPaper Published on:

  43. Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pat...

    Authors: Hyun-Kyu Park, Jae-Woo Cho, Byoung-Seok Lee, Heejin Park, Ji-Seok Han, Mi-Jin Yang, Wan-Jung Im, Do-Yong Park, Woo-Jin Kim, Su-Cheol Han and Yong-Bum Kim
    Citation: Laboratory Animal Research 2016 32:3202079
    Content type: OriginalPaper Published on:

  44. A 19-month-old male German shepherd dog was presented with a hindlimb footpad mass. The mass was excised and histopathology was performed. Grossly, the cut section of the mass had multiple wellcircumscribed no...

    Authors: Eun-Mi Lee, Ah-Young Kim, Eun-Joo Lee and Kyu-Shik Jeong
    Citation: Laboratory Animal Research 2016 32:10
    Content type: Case Report Published on:

  45. The C57BLKS/J-Leprdb mouse has a point mutation in the leptin receptor gene and is one of the most useful animal model for non-insulin dependent diabetes mellitus in human. Since the homozygote of C57BLKS/J-Leprd...

    Authors: Harry Jung, Hajin Nam and Jun-Gyo Suh
    Citation: Laboratory Animal Research 2016 32:9
    Content type: Letter Published on:

  47. Animal models for gastric ulcers produced by physical, pharmacological and surgical methods have been widely employed to evaluate therapeutic drugs and investigate the mechanism of action of this disease. ICR ...

    Authors: Sung Hwa Song, Ji Eun Kim, Jun Go, Eun Kyoung Koh, Ji Eun Sung, Hyun Ah Lee, Kyung Min Choi, Hae Deun Kim, Young Suk Jung, Kil Soo Kim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2016 32:7
    Content type: OriginalPaper Published on:

  48. A dysfunction of endoplasmic reticulum (ER) stress response can result in various diseases, including cancer, inflammation, diabetes and neurodegenerative disorders. To investigate whether ER stress response c...

    Authors: Ji-Eun Kim, Jun Go, Ji-Eun Sung, Hyun-Ah Lee, Eun-Ji Seo, Woo-Bin Yun and Dae-Youn Hwang
    Citation: Laboratory Animal Research 2016 32:3
    Content type: OriginalPaper Published on:

  49. The purpose of this study was to evaluate the effects of thiopental versus propofol on cardiopulmonary functions, when used as an induction agent prior to isoflurane anesthesia in rhesus monkeys. Eight healthy...

    Authors: Yun-Jung Choi, Hye-Jin Park, Hyeon-Ho Kim, Yun-Jin Lee, Kyeong-Cheon Jung, Seong-Hoe Park and Jae-Il Lee
    Citation: Laboratory Animal Research 2016 32:2
    Content type: OriginalPaper Published on:

  50. In this study, we observed the ontogenetic changes in glucose transporter 3 (GLUT3) immunoreactivity, a major neuronal GLUT, in the dentate gyrus of mouse brains at various ages: postnatal day (P) 1, 7, 14, 28...

    Authors: Hyo Young Jung, Hee Sun Yim, Dae Young Yoo, Jong Whi Kim, Jin Young Chung, Je Kyung Seong, Yeo Sung Yoon, Dae Won Kim and In Koo Hwang
    Citation: Laboratory Animal Research 2016 32:1
    Content type: OriginalPaper Published on:
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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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Laboratory Animal Research

ISSN: 2233-7660