Fig. 1

RbAp48 immunohistochemistry in CA1 of the sham operated (a) and ischemia operated (b-e) gerbils. In the sham operated gerbils, strong RbAp48 immunoreactivity is shown in pyramidal cells (thick arrows) and non-pyramidal cells (thin arrows). RbAp48 immunoreactivity is decreased in pyramidal cells at 2 days post-ischemia. At 5 days and 10 days post-ischemia, RbAp48 immunoreactive pyramidal cells (asterisks) were few; however, RbAp48 immunoreactive non-pyramidal cells (thin arrows) are significantly increased in numbers. SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum. Scale bar = 50 μm. (F, G) ROD as % of RbAp48 immunoreactive structures in the SP (f), and in the SO and SR (g) after transient ischemia (n = 7 at each point in time, ^*P < 0.05, significantly different from the sham operated group, ^†P < 0.05, significantly different from the pre-time point group). Bars indicate the means ± SEM