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  1. Recently a screen from a library of 1.8 million compounds identified in vitro a potent activity of the 2-aminobenzimidazoles series against Leishmania infantum, the etiological agent responsible by over 20.000 de...

    Authors: Hirla Costa Silva Fukushima, Ricardo Lacava Bailone, Tatiana Corrêa, Helena Janke, Luís Kluwe De Aguiar, Princia Grejo Setti and Ricardo Carneiro Borra

    Citation: Laboratory Animal Research 2021 37:27

    Content type: Research

    Published on:

  2. Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines express...

    Authors: Chong Pyo Choe, Seok-Yong Choi, Yun Kee, Min Jung Kim, Seok-Hyung Kim, Yoonsung Lee, Hae-Chul Park and Hyunju Ro

    Citation: Laboratory Animal Research 2021 37:26

    Content type: Review

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  3. Electrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart, electrolyte disturba...

    Authors: Siyavash Joukar

    Citation: Laboratory Animal Research 2021 37:25

    Content type: Review

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  4. CBA/J mice are standard experimental animals in auditory studies, and age-related changes in auditory pathways are well documented. However, changes in locomotion-related brain regions have not been systematic...

    Authors: Cheryl Tyszkiewicz, Ingrid D Pardo, Hayley N Ritenour, Chang-Ning Liu and Chris Somps

    Citation: Laboratory Animal Research 2021 37:24

    Content type: Research

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  5. Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high...

    Authors: Chidhambara Priya Dharshini Kottaisamy, Divya S. Raj, V. Prasanth Kumar and Umamaheswari Sankaran

    Citation: Laboratory Animal Research 2021 37:23

    Content type: Review

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  6. As a laboratory animal resource, the ICR mouse is commonly used in a variety of research fields. However, information on differences in exercise-related characteristics in ICR mice derived from different linea...

    Authors: Dong-Joo Hwang, Ki-Chun Kwon, Dong-Hun Choi, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang and Joon-Yong Cho

    Citation: Laboratory Animal Research 2021 37:21

    Content type: Research

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  7. Particulate matter (PM) is one of the principal causes of human respiratory disabilities resulting from air pollution. Animal models have been applied to discover preventive and therapeutic drugs for lung dise...

    Authors: Se Yong Park, Kyu Sup An, Buhyun Lee, Ju-Hee Kang, Hyun Jin Jung, Min Woo Kim, Hyeon Yeol Ryu, Kyu-Suk Shim, Ki Taek Nam, Yeo Sung Yoon and Seung Hyun Oh

    Citation: Laboratory Animal Research 2021 37:20

    Content type: Methodology

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  8. Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and thus mouse models of CRC are of significant value to study the pathogenesis. The Azoxymethane/Dextran sulfate sodium (AOM/D...

    Authors: Henriette Arnesen, Mette Helen Bjørge Müller, Mona Aleksandersen, Gunn Charlotte Østby, Harald Carlsen, Jan Erik Paulsen and Preben Boysen

    Citation: Laboratory Animal Research 2021 37:19

    Content type: Research

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  9. Hypothermic treatment is known to protect organs against cardiac arrest (CA) and improves survival rate. However, few studies have evaluated the effects of hypothermia on CA-induced liver damages. This study w...

    Authors: Donghwi Kim, Bora Kim, Hyejin Sim, Tae-Kyeong Lee, Hyun-Jin Tae, Jae-Chul Lee, Joon Ha Park, Jun Hwi Cho, Moo-Ho Won, Yoonsoo Park and Ji Hyeon Ahn

    Citation: Laboratory Animal Research 2021 37:16

    Content type: Research

    Published on:

  10. Nonhuman primates (NHPs) are superior model for ocular research due to its morphological and physiological similarities with humans. Thus, the effect of four different anesthetic combinations [ketamine (10 mg/...

    Authors: Hong-Soo Lee, Da-Hee Kim, Sung-Hwan Kim, Min-Sung Kang and Han Na Suh

    Citation: Laboratory Animal Research 2021 37:15

    Content type: Research

    Published on:

  11. The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an appro...

    Authors: Jong-Min Kim and Chung-Gyu Park

    Citation: Laboratory Animal Research 2021 37:14

    Content type: Research

    Published on:

  12. Blood collection is an important procedure used in animal experiments. Blood collection methods that reduce pain, injury, and stress in experimental animals are important with regard to animal ethics. Various ...

    Authors: Eun Jung Jo, Eunjin Bae, Jeong-Hwan Yoon, Ji Yeon Kim and Jin Soo Han

    Citation: Laboratory Animal Research 2021 37:12

    Content type: Research

    Published on:

  13. Aging is one of major causes triggering neurophysiological changes in many brain substructures, including the hippocampus, which has a major role in learning and memory. Thioredoxin (Trx) is a class of small r...

    Authors: Yeon Ho Yoo, Dae Won Kim, Bai Hui Chen, Hyejin Sim, Bora Kim, Jae-Chul Lee, Ji Hyeon Ahn, Yoonsoo Park, Jun Hwi Cho, Il Jun Kang, Moo-Ho Won and Tae-Kyeong Lee

    Citation: Laboratory Animal Research 2021 37:11

    Content type: Research

    Published on:

  14. Calcium is a critical factor involved in modulation of essential cellular functions. Parvalbumin is a calcium buffering protein that regulates intracellular calcium concentrations. It prevents rises in calcium...

    Authors: Dong-Ju Park, Ju-Bin Kang, Fawad-Ali Shah and Phil-Ok Koh

    Citation: Laboratory Animal Research 2021 37:9

    Content type: Research

    Published on:

  15. Inflammatory bowel disease (IBD), including both Crohn’s disease and ulcerative colitis, are chronic human diseases that are challenging to cure and are often unable to be resolved. The inbred mouse strain C57...

    Authors: Sou Hyun Kim, Doyoung Kwon, Seung Won Son, Tae Bin Jeong, Seunghyun Lee, Jae-Hwan Kwak, Joon-Yong Cho, Dae Youn Hwang, Min-Soo Seo, Kil Soo Kim and Young-Suk Jung

    Citation: Laboratory Animal Research 2021 37:8

    Content type: Research

    Published on:

  16. Online databases are crucial infrastructures to facilitate the wide effective and efficient use of mouse mutant resources in life sciences. The number and types of mouse resources have been rapidly growing due...

    Authors: Hiroshi Masuya, Daiki Usuda, Hatsumi Nakata, Naomi Yuhara, Keiko Kurihara, Yuri Namiki, Shigeru Iwase, Toyoyuki Takada, Nobuhiko Tanaka, Kenta Suzuki, Yuki Yamagata, Norio Kobayashi, Atsushi Yoshiki and Tatsuya Kushida

    Citation: Laboratory Animal Research 2021 37:6

    Content type: Review

    Published on:

  17. Sarcopenia promotes skeletal muscle atrophy and exhibits a high mortality rate. Its elucidation is of the highest clinical importance, but an animal experimental model remains controversial. In this study, we ...

    Authors: Akira Nemoto and Toru Goyagi

    Citation: Laboratory Animal Research 2021 37:7

    Content type: Research

    Published on:

  18. Sepsis, one of the most fatal diseases in the world, is known to culminate in multiple organ failure due to an uncontrolled inflammatory response. Hence, the use of animal models in sepsis research is very imp...

    Authors: Ji Won Park, Su Jin Lee, Ji Eun Kim, Mi Ju Kang, Su Ji Bae, Yun Ju Choi, Jeong Eun Gong, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Yeon Shik Choi, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2021 37:2

    Content type: Research

    Published on:

  19. Increases of neutrophils and osteoclasts are pathological changes of periodontitis. RANKL is an osteoclast differentiation factor. The effect of periodontopathogen LPS on RANKL-expressing neutrophils has not b...

    Authors: Ae Ri Kim, Yun Kyong Lim, Joong-Ki Kook, Eun-Jung Bak and Yun-Jung Yoo

    Citation: Laboratory Animal Research 2021 37:5

    Content type: Research

    Published on:

    The Correction to this article has been published in Laboratory Animal Research 2021 37:22

  20. Oryzias dancena (Beloniformes; Teleostei), is a euryhaline teleost that mainly inhabits the brackish or freshwater of river mouths and estuaries around the Bay of Bengal and the Malay Peninsula. It also has a sho...

    Authors: In-Seok Park

    Citation: Laboratory Animal Research 2021 37:4

    Content type: Review

    Published on:

  21. With the enactment of the Brazilian Law Arouca 11,794/2008 and Decree 6.899/2009, there has been an urgent need for changes in the processes related to animal experimentation in Brazil; in particular, there is...

    Authors: Eloiza K. G. D. Ferreira, Giovanny A. C. A. Mazzarotto and Guilherme F. Silveira

    Citation: Laboratory Animal Research 2021 37:1

    Content type: Research

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  22. Since the Three Rs of replacement, reduction and refinement was proposed by Russel and Birch in 1959, researchers have a moral duty to minimize harm to animals. Even though animal experiments are performed by ...

    Authors: Kook Hyun Lee, Dong Won Lee and Byeong Chul Kang

    Citation: Laboratory Animal Research 2020 36:45

    Content type: Mini-Review

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  23. Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not b...

    Authors: Nam Hee Youn, Eun Ji Kim, Jung-Sun Yi, Joo Hwan Kim, Ye-Jin Cho, Ki Taek Nam, Ki Sook Park and Jong Kwon Lee

    Citation: Laboratory Animal Research 2020 36:42

    Content type: Research

    Published on:

  24. WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age depe...

    Authors: Arun Prakash Mishra, Archana B. Siva, Chandrashekaran Gurunathan, Y. Komala and B. Jyothi Lakshmi

    Citation: Laboratory Animal Research 2020 36:41

    Content type: Research

    Published on:

  25. The effect of standard therapeutic strategies on Helicobacter pylori infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect...

    Authors: Hyun-A Lee, Joo-Yun Kim, Jisoo Kim, Bora Nam and Okjin Kim

    Citation: Laboratory Animal Research 2020 36:40

    Content type: Research

    Published on:

  26. The kainic acid-induced seizure mouse model is widely used in epilepsy research. In this study, we applied kainic acid to the subcutaneous injections of three different sources of DBA/2 mice to compare and eva...

    Authors: Kyung-Ku Kang, Young-In Kim, Min-Soo Seo, Soo-Eun Sung, Joo-Hee Choi, Sijoon Lee, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang, Sang-Joon Park and Kil Soo Kim

    Citation: Laboratory Animal Research 2020 36:39

    Content type: Research

    Published on:

  27. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease, which causes high fever, thrombocytopenia, and death in humans and animals in East Asian countries. The pathogenicity of SFTS...

    Authors: Seok-Chan Park, Jun Young Park, Jin Young Choi, Sung-Geun Lee, Seong Kug Eo, Jae-Ku Oem, Dong-Seob Tark, Myungjo You, Do-Hyeon Yu, Joon-Seok Chae and Bumseok Kim

    Citation: Laboratory Animal Research 2020 36:38

    Content type: Research

    Published on:

  28. In animal research, “refinement” refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Evaluation of drug efficacy in mice mo...

    Authors: Julián Ernesto Nicolás Gulin, Margarita Bisio and Facundo García-Bournissen

    Citation: Laboratory Animal Research 2020 36:37

    Content type: Methodology

    Published on:

  29. Anti-parasitics are frequently used in research animal facilities to treat a multitude of common infections, with pinworms and fur mites being amongst the most common. Ivermectin and selamectin are common oral...

    Authors: Peter A. Kropp, Gabrielle V. Rushing, Asa A. Brockman, Erin N. Z. Yu, Rebecca A. Ihrie and Maureen Gannon

    Citation: Laboratory Animal Research 2020 36:36

    Content type: Case Report

    Published on:

  30. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mi Ju Kang, Jeong Eun Gong, Ji Eun Kim, Hyeon Jun Choi, Su Ji Bae, Yun Ju Choi, Su Jin Lee, Min-Soo Seo, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Yong Lim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2020 36:35

    Content type: Correction

    Published on:

    The original article was published in Laboratory Animal Research 2020 36:30

  31. Glutamate induces neurotoxicity during brain development, causing nerve damage. Protein phosphatase 2A (PP2A) is a type of serine/threonine phosphatase that regulates various biological functions. Among the PP...

    Authors: Ju-Bin Kang, Dong-Ju Park, Hyun-Kyoung Son and Phil-Ok Koh

    Citation: Laboratory Animal Research 2020 36:34

    Content type: Research

    Published on:

  32. The cryopreservation of sperm and embryos is useful to efficiently archive valuable resources of genetically engineered mice. Till date, more than 60,000 strains of genetically engineered mice have been archiv...

    Authors: Toru Takeo, Satohiro Nakao, Yoshiko Nakagawa, Jorge M. Sztein and Naomi Nakagata

    Citation: Laboratory Animal Research 2020 36:33

    Content type: Review

    Published on:

  33. Baicalin is a natural flavonoid that exerts a variety of pharmaceutical effects such as anti-inflammatory and antioxidant. Lipopolysaccharide (LPS) is an endotoxin that releases inflammatory cytokines and indu...

    Authors: Murad-Ali Shah, Dong-Ju Park, Ju-Bin Kang, Myeong-Ok Kim and Phil-Ok Koh

    Citation: Laboratory Animal Research 2020 36:32

    Content type: Research

    Published on:

  34. Differences in responsiveness of BALB/c substrains have been investigated in various fields, including diabetes induction, corpus callosum deficiency, virus-induced demyelinating disease, aggressive behavior a...

    Authors: Mi Ju Kang, Jeong Eun Gong, Ji Eun Kim, Hyeon Jun Choi, Su Ji Bae, Yun Ju Choi, Su Jin Lee, Min-Soo Seo, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Yong Lim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2020 36:30

    Content type: Research

    Published on:

    The Correction to this article has been published in Laboratory Animal Research 2020 36:35

  35. C57BL/6NKorl mice are a novel mouse stock recently developed by the National Institute of Food and Drug Safety Evaluation in Korea. Extensive research into the nature of C57BL/6NKorl mice is being conducted. H...

    Authors: Dong-Joo Hwang, Ki-Chun Kwon, Dae-Youn Hwang, Min-Soo Seo, Kil-Soo Kim, Young-Suk Jung and Joon-Yong Cho

    Citation: Laboratory Animal Research 2020 36:29

    Content type: Research

    Published on:

  36. Obesity has been known as an independent risk factor for stroke. Effects of high-fat diet (HFD)-induced obesity on neuronal damage in the somatosensory cortex of animal models of cerebral ischemia have not bee...

    Authors: Won Joo Seo, Ji Hyeon Ahn, Tae-Kyeong Lee, Bora Kim, Jae-Chul Lee, Joon Ha Park, Yeon Ho Yoo, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won and Yoonsoo Park

    Citation: Laboratory Animal Research 2020 36:28

    Content type: Research

    Published on:

  37. Genome editing has recently emerged as a powerful tool for generating mutant mice. Small deletions of nucleotides in the target genes are frequently found in CRISPR/Cas9 mediated mutant mice. However, there ar...

    Authors: Inseon Bak, Doo-Jin Kim, Hyoung-Chin Kim, Hye-Jun Shin, Eunhye Yu, Kyeong-Won Yoo and Dae-Yeul Yu

    Citation: Laboratory Animal Research 2020 36:27

    Content type: Research

    Published on:

  38. Benign prostate hyperplasia (BPH) is a common disease in old-age males, accounting for approximately 77% of morbidity within the age range of 40 to 70 years. It has been shown that morbidity increases with soc...

    Authors: Dae-geon Kim, Hyo-Jeong Kwon, Jong-Hwan Lim, Joo-heon Kim and Kyu Pil Lee

    Citation: Laboratory Animal Research 2020 36:26

    Content type: Research

    Published on:

  39. Brain Factor-7® (BF-7), silk fibroin peptide, is known to be effective in improvement of memory and learning ability. In this study, the effects of BF-7 (10 mg/kg, p.o., pre-treatment for 7 days and post-treat...

    Authors: Yoohun Noh, Ji Hyeon Ahn, Ji-Won Lee, Junkee Hong, Tae-Kyeong Lee, Bora Kim, Sung-Su Kim and Moo-Ho Won

    Citation: Laboratory Animal Research 2020 36:24

    Content type: Research

    Published on:

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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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