Articles

Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging

Fat-mass and obesity-associated protein (Fto) is highly expressed in the brain including, the hippocampus, and its expression is significantly decreased in the brain of Alzheimer’s disease patients. In the pre...

Authors: Min Soo Kang, Woosuk Kim, Tae Hyeong Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang and Jung Hoon Choi

Degenerative joint disease in the temporomandibular joint with fibrous ankylosis in a rhesus macaque (Macaca mulatta)

Ankylosis in the temporomandibular joint (TMJ) is known to have various etiologies in veterinary medicine. We observed a case of fibrous ankylosis of the TMJ in a newly imported rhesus monkey (Macaca mulatta).

Authors: Su-Mi Kim, Chang-Gok Woo and Jong-Min Kim

Retraction Note: Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

An amendment to this paper has been published and can be accessed via the original article.

Authors: Jae Young Yu, Hanh Thuy Nguyen, Chul Soon Yong, Hyoung Geun Park, Joon Ho Jun and Jong Oh. Kim

Synaptic loss and amyloid beta alterations in the rodent hippocampus induced by streptozotocin injection into the cisterna magna

To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the p...

Authors: Yujin Ahn, Jincheol Seo, Junghyung Park, Jinyoung Won, Hyeon-Gu Yeo, Keonwoo Kim, Chang-Yeop Jeon, Jae-Won Huh, Sang-Rae Lee, Dong-Seok Lee and Youngjeon Lee

Evaluation of canine teeth crown reduction technique in macaques

The reduction of canine teeth in adult males in whom permanent canine teeth eruption occurs should be considered due to the safety of humans or other monkeys. The objective of this study was to evaluate the co...

Authors: Su-Mi Kim and Jong-Min Kim

Enhanced alcohol degradation and hepatic protective effects of an Acetobacter Pasteurianus-derived product, CureZyme-ACE, in an acute intoxication rat model

Excessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute i...

Authors: Eun-Jong Jeon, Yun-Sang Cho, Ae-Hyang Kim, Jae-Min Shim, Yi-Soo Kim, Zhe Piao, Young Chul Shin and Jungkee Kwon

Patient-derived xenografts as compatible models for precision oncology

Cancer is a very heterogeneous disease, displaying heterogeneity between patients (inter-tumoral heterogeneity) and heterogeneity within a patient (intra-tumoral heterogeneity). Precision oncology is a diagnos...

Authors: Sung-Yup Cho

Zebrafish as an alternative animal model in human and animal vaccination research

Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite rodents being the most wid...

Authors: Ricardo Lacava Bailone, Hirla Costa Silva Fukushima, Bianca Helena Ventura Fernandes, Luís Kluwe De Aguiar, Tatiana Corrêa, Helena Janke, Princia Grejo Setti, Roberto De Oliveira Roça and Ricardo Carneiro Borra

Highlights on selected microscopy techniques to study zebrafish developmental biology

Bio-imaging is a tedious task when it concerns exploring cell functions, developmental mechanisms, and other vital processes in vivo. Single-cell resolution is challenging due to different issues such as sampl...

Authors: Ahmed Abu-Siniyeh and Walid Al-Zyoud

Animal models for the risk assessment of viral pandemic potential

Pandemics affect human lives severely and globally. Experience predicts that there will be a pandemic for sure although the time is unknown. When a viral epidemic breaks out, assessing its pandemic risk is an ...

Authors: Mee Sook Park, Jin Il Kim, Joon-Yong Bae and Man-Seong Park

Therapeutic potential of stem cell-derived extracellular vesicles in osteoarthritis: preclinical study findings

Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeut...

Authors: Ki Hoon Kim, Jeong Hyun Jo, Hye Jin Cho, Tae Sub Park and Tae Min Kim

Rodent models for psychiatric disorders: problems and promises

Psychiatric disorders are a prevalent global health problem, over 900 million individuals affected by a continuum of mental and substance use disorders. Due to this high prevalence, and the substantial direct ...

Authors: Matthew Baker, Sa-Ik Hong, Seungwoo Kang and Doo-Sup Choi

Decrease of 14–3-3 proteins by glutamate exposure in the cerebral cortex of newborn rats

Glutamate is a representative excitatory neurotransmitter. However, excessive glutamate exposure causes neuronal cell damage by generating neuronal excitotoxicity. Excitotoxicity in neonates caused by glutamat...

Authors: Ju-Bin Kang, Seung-Yun Lee, Dong-Ju Park and Phil-Ok Koh

Characterization of aged male BALB/c_cenp mice as a model of dementia

Dementia is defined as cognitive impairment in more than one cognitive area and leads to an abnormal degree of impairment in the ability to remember past events. Among mice models of dementia the most used str...

Authors: Nashelly Esquivel, Yenela García, Bestraida Lores, Marivy Gutiérrez and Claudio Rodríguez

Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

The hepatitis B virus (HBV) infects approximately 240 million people worldwide, causing chronic liver disease (CLD) and liver cancer. Although numerous studies have been performed to date, unfortunately there ...

Authors: Dae-Yeul Yu

Compensatory role of C3 convertase on the strain difference for C3 protein expression in FVB/N, C3H/HeN and C57BL/6N mice

To investigate the role of complement C3 (C3) convertase on the strain difference for C3 protein expression in three inbred mice strains, we compared the levels of C2, C3 and C4 mRNA, as well as C3 protein and...

Authors: Ji Won Park, Ji Eun Kim, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae and Dae Youn Hwang

A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model

Aerobic exercise is well known to have a positive impact on body composition, muscle strength, and oxidative capacity. In animal model, both treadmill and wheel running exercise modalities have become more pop...

Authors: Youn Ju Kim, Hye Jin Kim, Won Jun Lee and Je Kyung Seong

Characterization and applications of chimeric mice with humanized livers for preclinical drug development

We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice to academia and pharmaceutical com...

Authors: Chise Tateno and Yuha Kojima

Evaluation of factors related to Anaesthesia-induced Lens opacity in experimental mice

To investigate conditions that cause temporal lens opacity, we tested chemical and physical factors, such as anaesthesia dose, ocular surface dryness, and infrared (IR) light exposure in anaesthetised C57BL/6 ...

Authors: Hun Lee, Hong Kyung Kim, Hae Sol Shin, Soo Jung Han, Sangchul Yoon, Je Kyung Seong and Kyoung Yul Seo

Four amino acids as serum biomarkers for anti-asthma effects in the ovalbumin-induced asthma mouse model treated with extract of Asparagus cochinchinensis

The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAW) effectively prevents inflammation and remodeling of airway in the ovalbumin (OVA)-induced asthma model. To characteriz...

Authors: Jun Young Choi, So Hyun Kim, Ji Eun Kim, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Jae Ho Lee, Young-Suk Jung and Dae Youn Hwang

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep

Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not ...

Authors: Gwang-Ho Kim and Sun Shin Yi

Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad

Signal transducer and activator of transcription 3 (STAT3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis,...

Authors: Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin and Seung Hyun Oh

Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

Coffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the effect of coffee on...

Authors: Teka Obsa Feyisa, Daniel Seifu Melka, Menakath Menon, Wajana Lako Labisso and Mezgebu Legesse Habte

An improvement in acute wound healing in rats by the synergistic effect of photobiomodulation and arginine

In this probe, at first we examined the best route and dosage of arginine administration on wound healing in an excisional wound model in rats. Next, we intend to assess the impact of photobiomodulation (PBM) ...

Authors: Atarodsadat Mostafavinia, Mohammad Bidram, Amirhossein Gomi Avili, Mohammadamin Mahmanzar, Seyed Ali Karimifard, Ensieh Sajadi, Abdollah Amini, Mahsa Hadipour Jahromy, Seyed Kamran Ghoreishi, Sufan Chien and Mohammad Bayat

Antitumor effect of TW-37, a BH3 mimetic in human oral cancer

TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied ...

Authors: Chi-Hyun Ahn, Won Woo Lee, Yun Chan Jung, Ji-Ae Shin, Kyoung-Ok Hong, Sujung Choi, Neeti Swarup, Jihoon Kim, Min-Hye Ahn, Minjung Jung, Sung-Dae Cho and Bohwan Jin

Implication of Porphyromonas gingivalis in colitis and homeostasis of intestinal epithelium

Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, ha...

Authors: Yoojin Seo, Su-Jeong Oh, Ji-Su Ahn, Ye Young Shin, Ji Won Yang and Hyung-Sik Kim

Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines

In the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), FMD (Foot-and-Mouth Disease) and AI (Avian Influenza)...

Authors: Gwang-Ho Kim and Sun Shin Yi

Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats

Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal c...

Authors: Ju-Bin Kang, Dong-Ju Park and Phil-Ok Koh

TarGo: network based target gene selection system for human disease related mouse models

Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with...

Authors: Daejin Hyung, Ann-Marie Mallon, Dong Soo Kyung, Soo Young Cho and Je Kyung Seong

Involvement of immune responses in pulmonary arterial hypertension; lessons from rodent models

Pulmonary hypertension (PH) is a pathological state with sustained elevation of pulmonary artery (PA) pressure. Since the pathogenesis of PH is mostly irreversible, the disease often comes up with poor prognos...

Authors: Kibyeong Kim and Jae-Hoon Choi

Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus

In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration ...

Authors: Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, Min Soo Kang, Jong Whi Kim, Kyu Ri Hahn, Dae Young Yoo, Yeo Sung Yoon, In Koo Hwang and Dae Won Kim

Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus

P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult and aged mice by usi...

Authors: Tae-Kyeong Lee, Young Eun Park, Cheol Woo Park, Bora Kim, Jae-Chul Lee, Joon Ha Park, Hyang-Ah Lee, Moo-Ho Won and Ji Hyeon Ahn

Lipopolysaccharide induces neuroglia activation and NF-κB activation in cerebral cortex of adult mice

Lipopolysaccharide (LPS) acts as an endotoxin, releases inflammatory cytokines, and promotes an inflammatory response in various tissues. This study investigated whether LPS modulates neuroglia activation and ...

Authors: Ju-Bin Kang, Dong-Ju Park, Murad-Ali Shah, Myeong-Ok Kim and Phil-Ok Koh

Resveratrol modulates the Akt/GSK-3β signaling pathway in a middle cerebral artery occlusion animal model

Cerebral ischemia is a major cause of neurodegenerative disease. It induces neuronal vulnerability and susceptibility, and leads to neuronal cell death. Resveratrol is a polyphenolic compound that acts as an a...

Authors: Dong-Ju Park, Ju-Bin Kang, Fawad-Ali Shah and Phil-Ok Koh

Comparison of responsiveness to cancer development and anti-cancer drug in three different C57BL/6N stocks

In our efforts to understand the systemic features of tumors, the importance of animal models is increasing due to the recent growth in the development of immunotherapy and targeted therapies. This has resulte...

Authors: Mi Ju Kang, Ji Eun Kim, Ji Won Park, Hyeon Jun Choi, Su Ji Bae, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Dae Youn Hwang and Hyun Keun Song

Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources

Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic...

Authors: Tae Bin Jeong, Joung-Hee Kim, Sou Hyun Kim, Seunghyun Lee, Seung Won Son, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim, Jae-Hwan Kwak and Young-Suk Jung

Comparative study of liver injury induced by high-fat methionine- and choline-deficient diet in ICR mice originating from three different sources

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. It is characterized by the accumulation of lipids without alcohol intake and often progresses to non-alcoholic...

Authors: Seunghyun Lee, Jae-Hwan Kwak, Sou Hyun Kim, Tae Bin Jeong, Seung Won Son, Joung-Hee Kim, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung

Correlation between synthesis of α₂-macroglobulin as acute phase protein and degree of hepatopathy in rats

The degree of hepatopathy affecting the synthesis of α₂-macroglobulin (α2M) as an acute phase protein in rats was investigated. Hepatopathy was induced in Sprague-Dawley rats by intravenous administration of gala...

Authors: Reina Ito and Takashi Kuribayashi

The effects of coenzyme Q₁₀ supplement on blood lipid indices and hepatic antioxidant defense system in SD rats fed a high cholesterol diet

A total of 24 SD rats were allotted to four treatment groups such as the control (CON), 1% of cholesterol diet (CHO), 0.5% of coenzyme Q₁₀ (COQ) and 1% of cholesterol plus 0.5% of coenzyme Q₁₀ (CHCQ) groups to de...

Authors: Ha-Na Kim, Dong-Gyung Jeon, Yong Lim and In-Surk Jang

RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia

Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion inj...

Authors: Joon Ha Park, Tae-Kyeong Lee, Dae Won Kim, Cheol Woo Park, Young Eun Park, Bora Kim, Jae-Chul Lee, Hyang-Ah Lee, Moo-Ho Won and Ji Hyeon Ahn

Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources

Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three differ...

Authors: Min-Soo Seo, Young-In Kim, Kyung-Ku Kang, Se-Kyung Oh, Soo-Eun Sung, Young-Suk Jung, Joon Yong Cho, HyunKeun Song, Dae Youn Hwang, Sang-Joon Park and Kil Soo Kim

Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources

MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is commonly used to induce nigrostriatal defects to induce parkinsonism and/or parkinsonian syndrome, to replicate the lesions seen in Parkinson’s disease (PD...

Authors: Dong-Joo Hwang, Ki-Chun Kwon, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang and Joon-Yong Cho

Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats

Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize put...

Authors: Ji Eun Kim, Young Ju Lee, Sung Ha Ryu, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Yusang Choi, Hyun Gu Kang, Kyu-Bong Kim, Suhkmann Kim, Yong Lim and Dae Youn Hwang

Aged mice show an increased mortality after anesthesia with a standard dose of ketamine/xylazine

Geriatric animal models are crucial for a better understanding and an improved therapy of age-related diseases. We observed a high mortality of aged mice after anesthesia with a standard dose of ketamine/xylaz...

Authors: Sandra Schuetze, Anja Manig, Sandra Ribes and Roland Nau

Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematol...

Authors: Bon-Sang Koo, Dong-Ho Lee, Philyong Kang, Kang-Jin Jeong, Sangil Lee, Kijin Kim, Youngjeon Lee, Jae-Won Huh, Young-Hyun Kim, Sang-Je Park, Yeung Bae Jin, Sun-Uk Kim, Ji-Su Kim, Yeonghoon Son and Sang-Rae Lee

Tracking acute phase protein response during acute and chronic Toxoplasma gondii infection

Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii, which occurs worldwide in mammals and birds. Brain is the primary target organ because Toxoplasma gondii is a ubiquitous intracellular parasit...

Authors: Hasan Tarik Atmaca, Aycan Nuriye Gazyagci, Osman Safa Terzi, Gungor Cagdas Dincel and Tugce Sumer

Comparison of the virulence of Streptococcus pneumoniae in ICR mouse stocks of three different origins

Streptococcus pneumoniae causes many people to suffer from pneumonia, septicemia, and other diseases worldwide. To identify the difference in susceptibility of and treatment efficacy against S. pneumoniae in thre...

Authors: Jun-Young Kim, Sun-Min Seo, Han-Kyul Lee, Han-Woong Kim and Yang-Kyu Choi

First comprehensive report of bacteria spp. associated with cloaca of Laudakia nupta (Sauria: Agamidae) in Iran using molecular studies

Iran bears a remarkable variety of reptiles. One of the lizard families occurring in Iran is the Family Agamidae which is widely are distributed throughout the old world. The large-scaled rock agamid, Laudakia nu...

Authors: Farkhondeh Sayyadi, Nasrullah Rastegar-Pouyani, Mehri Azadbakht and Khosrow Chehri

Evaluation of iNSiGHT VET DXA (Dual-Energy X-ray Absorptiometry) for assessing body composition in obese rats fed with high fat diet: a follow-up study of diet induced obesity model for 8 weeks

We examined the precision, accuracy, and capability of detecting changes of Dual-Energy X-ray Absorptiometry (DXA) for the measurements of total-body weight (TBW), total-body fat weight (TBFW), and total-body ...

Authors: Jungyun Yeu, Han-Jik Ko, Doyeun Kim, Youngbok Ahn, Jaejin Kim, Wonhee Lee, IlSin Jung, Jungkyu Suh and Seok-Jong Lee

Welcome to Laboratory Animal Research

Authors: Je Kyung Seong