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  1. Online databases are crucial infrastructures to facilitate the wide effective and efficient use of mouse mutant resources in life sciences. The number and types of mouse resources have been rapidly growing due...

    Authors: Hiroshi Masuya, Daiki Usuda, Hatsumi Nakata, Naomi Yuhara, Keiko Kurihara, Yuri Namiki, Shigeru Iwase, Toyoyuki Takada, Nobuhiko Tanaka, Kenta Suzuki, Yuki Yamagata, Norio Kobayashi, Atsushi Yoshiki and Tatsuya Kushida

    Citation: Laboratory Animal Research 2021 37:6

    Content type: Review

    Published on:

  2. Sarcopenia promotes skeletal muscle atrophy and exhibits a high mortality rate. Its elucidation is of the highest clinical importance, but an animal experimental model remains controversial. In this study, we ...

    Authors: Akira Nemoto and Toru Goyagi

    Citation: Laboratory Animal Research 2021 37:7

    Content type: Research

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  3. Sepsis, one of the most fatal diseases in the world, is known to culminate in multiple organ failure due to an uncontrolled inflammatory response. Hence, the use of animal models in sepsis research is very imp...

    Authors: Ji Won Park, Su Jin Lee, Ji Eun Kim, Mi Ju Kang, Su Ji Bae, Yun Ju Choi, Jeong Eun Gong, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Yeon Shik Choi, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2021 37:2

    Content type: Research

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  4. Increases of neutrophils and osteoclasts are pathological changes of periodontitis. RANKL is an osteoclast differentiation factor. The effect of periodontopathogen LPS on RANKL-expressing neutrophils has not b...

    Authors: Ae Ri Kim, Yun Kyong Lim, Joong-Ki Kook, Eun-Jung Bak and Yun-Jung Yoo

    Citation: Laboratory Animal Research 2021 37:5

    Content type: Research

    Published on:

  5. Oryzias dancena (Beloniformes; Teleostei), is a euryhaline teleost that mainly inhabits the brackish or freshwater of river mouths and estuaries around the Bay of Bengal and the Malay Peninsula. It also has a sho...

    Authors: In-Seok Park

    Citation: Laboratory Animal Research 2021 37:4

    Content type: Review

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  6. With the enactment of the Brazilian Law Arouca 11,794/2008 and Decree 6.899/2009, there has been an urgent need for changes in the processes related to animal experimentation in Brazil; in particular, there is...

    Authors: Eloiza K. G. D. Ferreira, Giovanny A. C. A. Mazzarotto and Guilherme F. Silveira

    Citation: Laboratory Animal Research 2021 37:1

    Content type: Research

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  7. Since the Three Rs of replacement, reduction and refinement was proposed by Russel and Birch in 1959, researchers have a moral duty to minimize harm to animals. Even though animal experiments are performed by ...

    Authors: Kook Hyun Lee, Dong Won Lee and Byeong Chul Kang

    Citation: Laboratory Animal Research 2020 36:45

    Content type: Mini-Review

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  8. Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not b...

    Authors: Nam Hee Youn, Eun Ji Kim, Jung-Sun Yi, Joo Hwan Kim, Ye-Jin Cho, Ki Taek Nam, Ki Sook Park and Jong Kwon Lee

    Citation: Laboratory Animal Research 2020 36:42

    Content type: Research

    Published on:

  9. WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age depe...

    Authors: Arun Prakash Mishra, Archana B. Siva, Chandrashekaran Gurunathan, Y. Komala and B. Jyothi Lakshmi

    Citation: Laboratory Animal Research 2020 36:41

    Content type: Research

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  10. The effect of standard therapeutic strategies on Helicobacter pylori infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect...

    Authors: Hyun-A Lee, Joo-Yun Kim, Jisoo Kim, Bora Nam and Okjin Kim

    Citation: Laboratory Animal Research 2020 36:40

    Content type: Research

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  11. The kainic acid-induced seizure mouse model is widely used in epilepsy research. In this study, we applied kainic acid to the subcutaneous injections of three different sources of DBA/2 mice to compare and eva...

    Authors: Kyung-Ku Kang, Young-In Kim, Min-Soo Seo, Soo-Eun Sung, Joo-Hee Choi, Sijoon Lee, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang, Sang-Joon Park and Kil Soo Kim

    Citation: Laboratory Animal Research 2020 36:39

    Content type: Research

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  12. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease, which causes high fever, thrombocytopenia, and death in humans and animals in East Asian countries. The pathogenicity of SFTS...

    Authors: Seok-Chan Park, Jun Young Park, Jin Young Choi, Sung-Geun Lee, Seong Kug Eo, Jae-Ku Oem, Dong-Seob Tark, Myungjo You, Do-Hyeon Yu, Joon-Seok Chae and Bumseok Kim

    Citation: Laboratory Animal Research 2020 36:38

    Content type: Research

    Published on:

  13. In animal research, “refinement” refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Evaluation of drug efficacy in mice mo...

    Authors: Julián Ernesto Nicolás Gulin, Margarita Bisio and Facundo García-Bournissen

    Citation: Laboratory Animal Research 2020 36:37

    Content type: Methodology

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  14. Anti-parasitics are frequently used in research animal facilities to treat a multitude of common infections, with pinworms and fur mites being amongst the most common. Ivermectin and selamectin are common oral...

    Authors: Peter A. Kropp, Gabrielle V. Rushing, Asa A. Brockman, Erin N. Z. Yu, Rebecca A. Ihrie and Maureen Gannon

    Citation: Laboratory Animal Research 2020 36:36

    Content type: Case Report

    Published on:

  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mi Ju Kang, Jeong Eun Gong, Ji Eun Kim, Hyeon Jun Choi, Su Ji Bae, Yun Ju Choi, Su Jin Lee, Min-Soo Seo, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Yong Lim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2020 36:35

    Content type: Correction

    Published on:

    The original article was published in Laboratory Animal Research 2020 36:30

  16. Glutamate induces neurotoxicity during brain development, causing nerve damage. Protein phosphatase 2A (PP2A) is a type of serine/threonine phosphatase that regulates various biological functions. Among the PP...

    Authors: Ju-Bin Kang, Dong-Ju Park, Hyun-Kyoung Son and Phil-Ok Koh

    Citation: Laboratory Animal Research 2020 36:34

    Content type: Research

    Published on:

  17. The cryopreservation of sperm and embryos is useful to efficiently archive valuable resources of genetically engineered mice. Till date, more than 60,000 strains of genetically engineered mice have been archiv...

    Authors: Toru Takeo, Satohiro Nakao, Yoshiko Nakagawa, Jorge M. Sztein and Naomi Nakagata

    Citation: Laboratory Animal Research 2020 36:33

    Content type: Review

    Published on:

  18. Baicalin is a natural flavonoid that exerts a variety of pharmaceutical effects such as anti-inflammatory and antioxidant. Lipopolysaccharide (LPS) is an endotoxin that releases inflammatory cytokines and indu...

    Authors: Murad-Ali Shah, Dong-Ju Park, Ju-Bin Kang, Myeong-Ok Kim and Phil-Ok Koh

    Citation: Laboratory Animal Research 2020 36:32

    Content type: Research

    Published on:

  19. Differences in responsiveness of BALB/c substrains have been investigated in various fields, including diabetes induction, corpus callosum deficiency, virus-induced demyelinating disease, aggressive behavior a...

    Authors: Mi Ju Kang, Jeong Eun Gong, Ji Eun Kim, Hyeon Jun Choi, Su Ji Bae, Yun Ju Choi, Su Jin Lee, Min-Soo Seo, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Yong Lim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2020 36:30

    Content type: Research

    Published on:

    The Correction to this article has been published in Laboratory Animal Research 2020 36:35

  20. C57BL/6NKorl mice are a novel mouse stock recently developed by the National Institute of Food and Drug Safety Evaluation in Korea. Extensive research into the nature of C57BL/6NKorl mice is being conducted. H...

    Authors: Dong-Joo Hwang, Ki-Chun Kwon, Dae-Youn Hwang, Min-Soo Seo, Kil-Soo Kim, Young-Suk Jung and Joon-Yong Cho

    Citation: Laboratory Animal Research 2020 36:29

    Content type: Research

    Published on:

  21. Obesity has been known as an independent risk factor for stroke. Effects of high-fat diet (HFD)-induced obesity on neuronal damage in the somatosensory cortex of animal models of cerebral ischemia have not bee...

    Authors: Won Joo Seo, Ji Hyeon Ahn, Tae-Kyeong Lee, Bora Kim, Jae-Chul Lee, Joon Ha Park, Yeon Ho Yoo, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won and Yoonsoo Park

    Citation: Laboratory Animal Research 2020 36:28

    Content type: Research

    Published on:

  22. Genome editing has recently emerged as a powerful tool for generating mutant mice. Small deletions of nucleotides in the target genes are frequently found in CRISPR/Cas9 mediated mutant mice. However, there ar...

    Authors: Inseon Bak, Doo-Jin Kim, Hyoung-Chin Kim, Hye-Jun Shin, Eunhye Yu, Kyeong-Won Yoo and Dae-Yeul Yu

    Citation: Laboratory Animal Research 2020 36:27

    Content type: Research

    Published on:

  23. Benign prostate hyperplasia (BPH) is a common disease in old-age males, accounting for approximately 77% of morbidity within the age range of 40 to 70 years. It has been shown that morbidity increases with soc...

    Authors: Dae-geon Kim, Hyo-Jeong Kwon, Jong-Hwan Lim, Joo-heon Kim and Kyu Pil Lee

    Citation: Laboratory Animal Research 2020 36:26

    Content type: Research

    Published on:

  24. Brain Factor-7® (BF-7), silk fibroin peptide, is known to be effective in improvement of memory and learning ability. In this study, the effects of BF-7 (10 mg/kg, p.o., pre-treatment for 7 days and post-treat...

    Authors: Yoohun Noh, Ji Hyeon Ahn, Ji-Won Lee, Junkee Hong, Tae-Kyeong Lee, Bora Kim, Sung-Su Kim and Moo-Ho Won

    Citation: Laboratory Animal Research 2020 36:24

    Content type: Research

    Published on:

  25. Human angiotensin-converting enzyme 2 (hACE2) has recently received a great attention due to it play a critical role as SARS-CoV receptor in the infection of human body. However, no further analysis for gene r...

    Authors: Su Hae Lee, Seung Wan Jee, Dae Youn Hwang and Jong Koo Kang

    Citation: Laboratory Animal Research 2020 36:23

    Content type: Research

    Published on:

  26. Fat-mass and obesity-associated protein (Fto) is highly expressed in the brain including, the hippocampus, and its expression is significantly decreased in the brain of Alzheimer’s disease patients. In the pre...

    Authors: Min Soo Kang, Woosuk Kim, Tae Hyeong Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang and Jung Hoon Choi

    Citation: Laboratory Animal Research 2020 36:20

    Content type: Research

    Published on:

  27. Ankylosis in the temporomandibular joint (TMJ) is known to have various etiologies in veterinary medicine. We observed a case of fibrous ankylosis of the TMJ in a newly imported rhesus monkey (Macaca mulatta).

    Authors: Su-Mi Kim, Chang-Gok Woo and Jong-Min Kim

    Citation: Laboratory Animal Research 2020 36:19

    Content type: Case Report

    Published on:

  28. To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the p...

    Authors: Yujin Ahn, Jincheol Seo, Junghyung Park, Jinyoung Won, Hyeon-Gu Yeo, Keonwoo Kim, Chang-Yeop Jeon, Jae-Won Huh, Sang-Rae Lee, Dong-Seok Lee and Youngjeon Lee

    Citation: Laboratory Animal Research 2020 36:17

    Content type: Research

    Published on:

  29. Excessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute i...

    Authors: Eun-Jong Jeon, Yun-Sang Cho, Ae-Hyang Kim, Jae-Min Shim, Yi-Soo Kim, Zhe Piao, Young Chul Shin and Jungkee Kwon

    Citation: Laboratory Animal Research 2020 36:15

    Content type: Research

    Published on:

  30. Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite rodents being the most wid...

    Authors: Ricardo Lacava Bailone, Hirla Costa Silva Fukushima, Bianca Helena Ventura Fernandes, Luís Kluwe De Aguiar, Tatiana Corrêa, Helena Janke, Princia Grejo Setti, Roberto De Oliveira Roça and Ricardo Carneiro Borra

    Citation: Laboratory Animal Research 2020 36:13

    Content type: Review

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  31. Pandemics affect human lives severely and globally. Experience predicts that there will be a pandemic for sure although the time is unknown. When a viral epidemic breaks out, assessing its pandemic risk is an ...

    Authors: Mee Sook Park, Jin Il Kim, Joon-Yong Bae and Man-Seong Park

    Citation: Laboratory Animal Research 2020 36:11

    Content type: Review

    Published on:

  32. Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeut...

    Authors: Ki Hoon Kim, Jeong Hyun Jo, Hye Jin Cho, Tae Sub Park and Tae Min Kim

    Citation: Laboratory Animal Research 2020 36:10

    Content type: Review

    Published on:

  33. Psychiatric disorders are a prevalent global health problem, over 900 million individuals affected by a continuum of mental and substance use disorders. Due to this high prevalence, and the substantial direct ...

    Authors: Matthew Baker, Sa-Ik Hong, Seungwoo Kang and Doo-Sup Choi

    Citation: Laboratory Animal Research 2020 36:9

    Content type: Review

    Published on:

  34. Dementia is defined as cognitive impairment in more than one cognitive area and leads to an abnormal degree of impairment in the ability to remember past events. Among mice models of dementia the most used str...

    Authors: Nashelly Esquivel, Yenela García, Bestraida Lores, Marivy Gutiérrez and Claudio Rodríguez

    Citation: Laboratory Animal Research 2020 36:7

    Content type: Research

    Published on:

  35. To investigate the role of complement C3 (C3) convertase on the strain difference for C3 protein expression in three inbred mice strains, we compared the levels of C2, C3 and C4 mRNA, as well as C3 protein and...

    Authors: Ji Won Park, Ji Eun Kim, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae and Dae Youn Hwang

    Citation: Laboratory Animal Research 2020 36:4

    Content type: Research

    Published on:

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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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