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  1. Glutamate induces neurotoxicity during brain development, causing nerve damage. Protein phosphatase 2A (PP2A) is a type of serine/threonine phosphatase that regulates various biological functions. Among the PP...

    Authors: Ju-Bin Kang, Dong-Ju Park, Hyun-Kyoung Son and Phil-Ok Koh

    Citation: Laboratory Animal Research 2020 36:34

    Content type: Research

    Published on:

  2. The cryopreservation of sperm and embryos is useful to efficiently archive valuable resources of genetically engineered mice. Till date, more than 60,000 strains of genetically engineered mice have been archiv...

    Authors: Toru Takeo, Satohiro Nakao, Yoshiko Nakagawa, Jorge M. Sztein and Naomi Nakagata

    Citation: Laboratory Animal Research 2020 36:33

    Content type: Review

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  3. Baicalin is a natural flavonoid that exerts a variety of pharmaceutical effects such as anti-inflammatory and antioxidant. Lipopolysaccharide (LPS) is an endotoxin that releases inflammatory cytokines and indu...

    Authors: Murad-Ali Shah, Dong-Ju Park, Ju-Bin Kang, Myeong-Ok Kim and Phil-Ok Koh

    Citation: Laboratory Animal Research 2020 36:32

    Content type: Research

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  4. Differences in responsiveness of BALB/c substrains have been investigated in various fields, including diabetes induction, corpus callosum deficiency, virus-induced demyelinating disease, aggressive behavior a...

    Authors: Mi Ju Kang, Jeong Eun Gong, Ji Eun Kim, Hyeon Jun Choi, Su Ji Bae, Yun Ju Choi, Su Jin Lee, Min-Soo Seo, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Yong Lim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2020 36:30

    Content type: Research

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  5. C57BL/6NKorl mice are a novel mouse stock recently developed by the National Institute of Food and Drug Safety Evaluation in Korea. Extensive research into the nature of C57BL/6NKorl mice is being conducted. H...

    Authors: Dong-Joo Hwang, Ki-Chun Kwon, Dae-Youn Hwang, Min-Soo Seo, Kil-Soo Kim, Young-Suk Jung and Joon-Yong Cho

    Citation: Laboratory Animal Research 2020 36:29

    Content type: Research

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  6. Obesity has been known as an independent risk factor for stroke. Effects of high-fat diet (HFD)-induced obesity on neuronal damage in the somatosensory cortex of animal models of cerebral ischemia have not bee...

    Authors: Won Joo Seo, Ji Hyeon Ahn, Tae-Kyeong Lee, Bora Kim, Jae-Chul Lee, Joon Ha Park, Yeon Ho Yoo, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won and Yoonsoo Park

    Citation: Laboratory Animal Research 2020 36:28

    Content type: Research

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  7. Genome editing has recently emerged as a powerful tool for generating mutant mice. Small deletions of nucleotides in the target genes are frequently found in CRISPR/Cas9 mediated mutant mice. However, there ar...

    Authors: Inseon Bak, Doo-Jin Kim, Hyoung-Chin Kim, Hye-Jun Shin, Eunhye Yu, Kyeong-Won Yoo and Dae-Yeul Yu

    Citation: Laboratory Animal Research 2020 36:27

    Content type: Research

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  8. Benign prostate hyperplasia (BPH) is a common disease in old-age males, accounting for approximately 77% of morbidity within the age range of 40 to 70 years. It has been shown that morbidity increases with soc...

    Authors: Dae-geon Kim, Hyo-Jeong Kwon, Jong-Hwan Lim, Joo-heon Kim and Kyu Pil Lee

    Citation: Laboratory Animal Research 2020 36:26

    Content type: Research

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  9. Brain Factor-7® (BF-7), silk fibroin peptide, is known to be effective in improvement of memory and learning ability. In this study, the effects of BF-7 (10 mg/kg, p.o., pre-treatment for 7 days and post-treat...

    Authors: Yoohun Noh, Ji Hyeon Ahn, Ji-Won Lee, Junkee Hong, Tae-Kyeong Lee, Bora Kim, Sung-Su Kim and Moo-Ho Won

    Citation: Laboratory Animal Research 2020 36:24

    Content type: Research

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  10. Human angiotensin-converting enzyme 2 (hACE2) has recently received a great attention due to it play a critical role as SARS-CoV receptor in the infection of human body. However, no further analysis for gene r...

    Authors: Su Hae Lee, Seung Wan Jee, Dae Youn Hwang and Jong Koo Kang

    Citation: Laboratory Animal Research 2020 36:23

    Content type: Research

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  11. Fat-mass and obesity-associated protein (Fto) is highly expressed in the brain including, the hippocampus, and its expression is significantly decreased in the brain of Alzheimer’s disease patients. In the pre...

    Authors: Min Soo Kang, Woosuk Kim, Tae Hyeong Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang and Jung Hoon Choi

    Citation: Laboratory Animal Research 2020 36:20

    Content type: Research

    Published on:

  12. Ankylosis in the temporomandibular joint (TMJ) is known to have various etiologies in veterinary medicine. We observed a case of fibrous ankylosis of the TMJ in a newly imported rhesus monkey (Macaca mulatta).

    Authors: Su-Mi Kim, Chang-Gok Woo and Jong-Min Kim

    Citation: Laboratory Animal Research 2020 36:19

    Content type: Case Report

    Published on:

  13. To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the p...

    Authors: Yujin Ahn, Jincheol Seo, Junghyung Park, Jinyoung Won, Hyeon-Gu Yeo, Keonwoo Kim, Chang-Yeop Jeon, Jae-Won Huh, Sang-Rae Lee, Dong-Seok Lee and Youngjeon Lee

    Citation: Laboratory Animal Research 2020 36:17

    Content type: Research

    Published on:

  14. Excessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute i...

    Authors: Eun-Jong Jeon, Yun-Sang Cho, Ae-Hyang Kim, Jae-Min Shim, Yi-Soo Kim, Zhe Piao, Young Chul Shin and Jungkee Kwon

    Citation: Laboratory Animal Research 2020 36:15

    Content type: Research

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  15. Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite rodents being the most wid...

    Authors: Ricardo Lacava Bailone, Hirla Costa Silva Fukushima, Bianca Helena Ventura Fernandes, Luís Kluwe De Aguiar, Tatiana Corrêa, Helena Janke, Princia Grejo Setti, Roberto De Oliveira Roça and Ricardo Carneiro Borra

    Citation: Laboratory Animal Research 2020 36:13

    Content type: Review

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  16. Pandemics affect human lives severely and globally. Experience predicts that there will be a pandemic for sure although the time is unknown. When a viral epidemic breaks out, assessing its pandemic risk is an ...

    Authors: Mee Sook Park, Jin Il Kim, Joon-Yong Bae and Man-Seong Park

    Citation: Laboratory Animal Research 2020 36:11

    Content type: Review

    Published on:

  17. Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeut...

    Authors: Ki Hoon Kim, Jeong Hyun Jo, Hye Jin Cho, Tae Sub Park and Tae Min Kim

    Citation: Laboratory Animal Research 2020 36:10

    Content type: Review

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  18. Psychiatric disorders are a prevalent global health problem, over 900 million individuals affected by a continuum of mental and substance use disorders. Due to this high prevalence, and the substantial direct ...

    Authors: Matthew Baker, Sa-Ik Hong, Seungwoo Kang and Doo-Sup Choi

    Citation: Laboratory Animal Research 2020 36:9

    Content type: Review

    Published on:

  19. Dementia is defined as cognitive impairment in more than one cognitive area and leads to an abnormal degree of impairment in the ability to remember past events. Among mice models of dementia the most used str...

    Authors: Nashelly Esquivel, Yenela García, Bestraida Lores, Marivy Gutiérrez and Claudio Rodríguez

    Citation: Laboratory Animal Research 2020 36:7

    Content type: Research

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  20. To investigate the role of complement C3 (C3) convertase on the strain difference for C3 protein expression in three inbred mice strains, we compared the levels of C2, C3 and C4 mRNA, as well as C3 protein and...

    Authors: Ji Won Park, Ji Eun Kim, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae and Dae Youn Hwang

    Citation: Laboratory Animal Research 2020 36:4

    Content type: Research

    Published on:

  21. To investigate conditions that cause temporal lens opacity, we tested chemical and physical factors, such as anaesthesia dose, ocular surface dryness, and infrared (IR) light exposure in anaesthetised C57BL/6 ...

    Authors: Hun Lee, Hong Kyung Kim, Hae Sol Shin, Soo Jung Han, Sangchul Yoon, Je Kyung Seong and Kyoung Yul Seo

    Citation: Laboratory Animal Research 2020 36:1

    Content type: Research

    Published on:

  22. The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAW) effectively prevents inflammation and remodeling of airway in the ovalbumin (OVA)-induced asthma model. To characteriz...

    Authors: Jun Young Choi, So Hyun Kim, Ji Eun Kim, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Jae Ho Lee, Young-Suk Jung and Dae Youn Hwang

    Citation: Laboratory Animal Research 2019 35:32

    Content type: Research

    Published on:

  23. Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not ...

    Authors: Gwang-Ho Kim and Sun Shin Yi

    Citation: Laboratory Animal Research 2019 35:31

    Content type: Research

    Published on:

  24. Signal transducer and activator of transcription 3 (STAT3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis,...

    Authors: Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin and Seung Hyun Oh

    Citation: Laboratory Animal Research 2019 35:30

    Content type: Research

    Published on:

  25. Coffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the effect of coffee on...

    Authors: Teka Obsa Feyisa, Daniel Seifu Melka, Menakath Menon, Wajana Lako Labisso and Mezgebu Legesse Habte

    Citation: Laboratory Animal Research 2019 35:29

    Content type: Research

    Published on:

  26. In this probe, at first we examined the best route and dosage of arginine administration on wound healing in an excisional wound model in rats. Next, we intend to assess the impact of photobiomodulation (PBM) ...

    Authors: Atarodsadat Mostafavinia, Mohammad Bidram, Amirhossein Gomi Avili, Mohammadamin Mahmanzar, Seyed Ali Karimifard, Ensieh Sajadi, Abdollah Amini, Mahsa Hadipour Jahromy, Seyed Kamran Ghoreishi, Sufan Chien and Mohammad Bayat

    Citation: Laboratory Animal Research 2019 35:28

    Content type: Research

    Published on:

  27. TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied ...

    Authors: Chi-Hyun Ahn, Won Woo Lee, Yun Chan Jung, Ji-Ae Shin, Kyoung-Ok Hong, Sujung Choi, Neeti Swarup, Jihoon Kim, Min-Hye Ahn, Minjung Jung, Sung-Dae Cho and Bohwan Jin

    Citation: Laboratory Animal Research 2019 35:27

    Content type: Research

    Published on:

  28. Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, ha...

    Authors: Yoojin Seo, Su-Jeong Oh, Ji-Su Ahn, Ye Young Shin, Ji Won Yang and Hyung-Sik Kim

    Citation: Laboratory Animal Research 2019 35:26

    Content type: Research

    Published on:

  29. Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal c...

    Authors: Ju-Bin Kang, Dong-Ju Park and Phil-Ok Koh

    Citation: Laboratory Animal Research 2019 35:24

    Content type: Research

    Published on:

  30. Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with...

    Authors: Daejin Hyung, Ann-Marie Mallon, Dong Soo Kyung, Soo Young Cho and Je Kyung Seong

    Citation: Laboratory Animal Research 2019 35:23

    Content type: Research

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  31. In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration ...

    Authors: Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, Min Soo Kang, Jong Whi Kim, Kyu Ri Hahn, Dae Young Yoo, Yeo Sung Yoon, In Koo Hwang and Dae Won Kim

    Citation: Laboratory Animal Research 2019 35:21

    Content type: Research

    Published on:

  32. P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult and aged mice by usi...

    Authors: Tae-Kyeong Lee, Young Eun Park, Cheol Woo Park, Bora Kim, Jae-Chul Lee, Joon Ha Park, Hyang-Ah Lee, Moo-Ho Won and Ji Hyeon Ahn

    Citation: Laboratory Animal Research 2019 35:20

    Content type: Research

    Published on:

  33. Lipopolysaccharide (LPS) acts as an endotoxin, releases inflammatory cytokines, and promotes an inflammatory response in various tissues. This study investigated whether LPS modulates neuroglia activation and ...

    Authors: Ju-Bin Kang, Dong-Ju Park, Murad-Ali Shah, Myeong-Ok Kim and Phil-Ok Koh

    Citation: Laboratory Animal Research 2019 35:19

    Content type: Research

    Published on:

  34. Cerebral ischemia is a major cause of neurodegenerative disease. It induces neuronal vulnerability and susceptibility, and leads to neuronal cell death. Resveratrol is a polyphenolic compound that acts as an a...

    Authors: Dong-Ju Park, Ju-Bin Kang, Fawad-Ali Shah and Phil-Ok Koh

    Citation: Laboratory Animal Research 2019 35:18

    Content type: Research

    Published on:

  35. In our efforts to understand the systemic features of tumors, the importance of animal models is increasing due to the recent growth in the development of immunotherapy and targeted therapies. This has resulte...

    Authors: Mi Ju Kang, Ji Eun Kim, Ji Won Park, Hyeon Jun Choi, Su Ji Bae, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2019 35:17

    Content type: Research

    Published on:

  36. Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic...

    Authors: Tae Bin Jeong, Joung-Hee Kim, Sou Hyun Kim, Seunghyun Lee, Seung Won Son, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim, Jae-Hwan Kwak and Young-Suk Jung

    Citation: Laboratory Animal Research 2019 35:16

    Content type: Research

    Published on:

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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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