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  1. Alzheimer's disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability. Although the underlying cause of AD is yet unknown, o...

    Authors: Swati Pant, Mohan Gupta, Tulika Anthwal, Monika Chauhan and Sumitra Nain
    Citation: Laboratory Animal Research 2024 40:9
  2. Ischemic stroke is a serious neurological disorder caused by blockages in cerebral artery. Protein phosphatase 2A (PP2A) is a phosphatase that performs a critical role in cell signaling and growth. PP2A subuni...

    Authors: Ju-Bin Kang, Hyun-Kyoung Son, Dong-Ju Park, Yeung-Bae Jin and Phil-Ok Koh
    Citation: Laboratory Animal Research 2024 40:8
  3. Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research. Hematological and biochemical laboratory data are essential for evaluating specific variations in the ...

    Authors: Suresh Patel, Satish Patel, Ashvin Kotadiya, Samir Patel, Bhavesh Shrimali, Nikita Joshi, Tushar Patel, Harshida Trivedi, Jitendra Patel, Amit Joharapurkar and Mukul Jain
    Citation: Laboratory Animal Research 2024 40:7
  4. The effects of housing conditions on animal physiology, behavior or stress are still debated. The aim of this study was to investigate the effects of three different housing systems, individually ventilated ca...

    Authors: İsmail Abidin, Hatice Keser, Elif Şahin, Hilal Öztürk, Harun Başoğlu, Ahmet Alver and Selcen Aydin-Abidin
    Citation: Laboratory Animal Research 2024 40:6
  5. Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting many organs, including the testis. Naringin from orange peel extract (OPE) is a flavanone with fertility-enhancing properties. Hence, this stud...

    Authors: Kazeem Bidemi Okesina, Adeyemi Fatai Odetayo, Wale Johnson Adeyemi, Ayodeji Johnson Ajibare, Akeem Ayodeji Okesina and Luqman Aribidesi Olayaki
    Citation: Laboratory Animal Research 2024 40:5
  6. Phytoestrogens, such as isoflavones, are known for their capacity to simulate various physiological impacts of estrogen in the human body. Our research evaluated the effects of isoflavone-enriched soybean leav...

    Authors: Dae Young Yoo, Cheng-liang Xie, Joo Yeon Jeong, Ki Hun Park, Sang Soo Kang and Dong Hoon Lee
    Citation: Laboratory Animal Research 2024 40:4
  7. High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the...

    Authors: Vipin Kumar Verma, Salma Malik, Ekta Mutneja, Anil Kumar Sahu, Vaishali Prajapati, Prashant Mishra, Jagriti Bhatia and Dharamveer Singh Arya
    Citation: Laboratory Animal Research 2024 40:3
  8. Pterospermum rubiginosum has been traditionally used by the tribal inhabitants of Southern India for treating bone fractures and as a local anti-inflammatory agent; however, experimental evidence to support this ...

    Authors: Rajamohanan Jalaja Anish, Aswathy Nair, V. Saraswathy, Velappan Nair S. Kalpana and Rajendran L. Shyma
    Citation: Laboratory Animal Research 2024 40:2
  9. Methamphetamine (MA) is a highly abused psychostimulant across all age groups including pregnant women. Because developing brain is vulnerable by the action of drugs, or other noxious stimuli, the aim of our s...

    Authors: Barbora Čechová, Jana Jurčovičová, Ivana Petríková, Šimon Vaculín, Štěpán Šandera and Romana Šlamberová
    Citation: Laboratory Animal Research 2024 40:1
  10. Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse models with different genomic backgrounds. Disease data of sex...

    Authors: Wei Dong, Cheng Tian, Z. Galvin Li, David Brand, Yanhong Cao, Xiaoyun Liu, Jiamin Ma, Andy Chai, Linda K. Myers, Jian Yan, Karen Hasty, John Stuart, Yan Jiao, Weikuan Gu and Xiaojun Cai
    Citation: Laboratory Animal Research 2023 39:35
  11. This study aimed to establish an image evaluation grading criteria for experimental stifle joint osteoarthritis (OA) in anterior cruciate ligament transection induced OA beagle dog models. The severity of OA w...

    Authors: Beomseok Rhee, Changfan Jin, Seo-Hyun Shin, Hojung Choi, Youngwon Lee and Sokho Kim
    Citation: Laboratory Animal Research 2023 39:34
  12. Alzheimer’s disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder. As the exact cause of the disease is still unclear, the drug development is very challenging. This review encompass...

    Authors: Rishika Dhapola, Sneha Kumari, Prajjwal Sharma and Dibbanti HariKrishnaReddy
    Citation: Laboratory Animal Research 2023 39:33
  13. Unlike conventional T cells, innate and virtual-memory CD8 T cells in naïve mice acquire their memory phenotypes and functions in the absence of antigenic encounters in a cytokine-dependent manner. The relevan...

    Authors: Hi Jung Park, Eun Ah Choi, Sung Min Choi, Young-Ki Choi, Jae Il Lee and Kyeong Cheon Jung
    Citation: Laboratory Animal Research 2023 39:32
  14. Sensorineural hearing loss (SNHL), caused by pathology in the cochlea, is the most common type of hearing loss in humans. It is generally irreversible with very few effective pharmacological treatments availab...

    Authors: Po-Yi Lue, Mark H. Oliver, Michel Neeff, Peter R. Thorne and Haruna Suzuki-Kerr
    Citation: Laboratory Animal Research 2023 39:31
  15. The gut–brain axis (GBA) in Parkinson's disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut microbiota being considered one of the major treatment targets for neurodegen...

    Authors: Ji Eun Kim, Ki Chun Kwon, You Jeong Jin, Ayun Seol, Hee Jin Song, Yu Jeong Roh, Tae Ryeol Kim, Eun Seo Park, Gi Ho Park, Ji Won Park, Young Suk Jung, Joon Yong Cho and Dae Youn Hwang
    Citation: Laboratory Animal Research 2023 39:30
  16. We aimed to examine the accompanying and solo impacts of conditioned medium of human adipose-derived stem cells (h-ASC-COM) and photobiomodulation (PBM) on the maturation stage of an ischemic infected delayed-...

    Authors: Kaysan Sohrabi, Houssein Ahmadi, Abdollah Amini, Behnaz Ahrabi, Atarodalsadat Mostafavinia, Hamidreza Omidi, Mansooreh Mirzaei, Fatemeh Fadaei Fathabady, Mohammadjavad Fridoni, Maryam Rahmannia, Sufan Chien and Mohammad Bayat
    Citation: Laboratory Animal Research 2023 39:29
  17. Feline mammary carcinoma (FMC) is one of the most prevalent malignancies of female cats. FMC is highly metastatic and thus leads to poor disease outcomes. Among all metastases, liver metastasis occurs in about...

    Authors: Yi-Chih Chang, Hao-Ping Liu, Hsiao-Li Chuang, Jiunn-Wang Liao, Pei-Ling Kao, Hsun-Lung Chan, Ter-Hsin Chen and Yu-Chih Wang
    Citation: Laboratory Animal Research 2023 39:27
  18. Influenza A viruses (IAVs) have long posed a threat to humans, occasionally causing significant morbidity and mortality. The initial immune response is triggered by infected epithelial cells, alveolar macropha...

    Authors: Eun Ah Choi, Hi Jung Park, Sung Min Choi, Jae Il Lee and Kyeong Cheon Jung
    Citation: Laboratory Animal Research 2023 39:26
  19. Chronic skin wounds are a common complication of many diseases such as diabetes. Various traditional methods for assessing skin wound closure are used in animal studies, including wound tracing, calliper measu...

    Authors: Coco X. Huang, Elisha Siwan, Sarah L. Fox, Matilda Longfield, Stephen M. Twigg and Danqing Min
    Citation: Laboratory Animal Research 2023 39:25
  20. The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institut...

    Authors: Gwang-Hoon Lee, Woori Jo, Joon-Suk Park, Tae-Ku Kang, Soo-Eun Sung, Taeho Oh and KilSoo Kim
    Citation: Laboratory Animal Research 2023 39:24
  21. To evaluate the chemosensitivity to doxorubicin (DOX) in two primary cells derived from a tumor of FVB/N-Trp53tm1Hw1 knockout (KO) mice with TALEN-mediated Trp53 mutant gene, we evaluated the cell survivability, ...

    Authors: Woobin Yun, Ji Eun Kim, You Jeong Jin, Yu Jeong Roh, Hee Jin Song, Ayun Seol, Tae Ryeol Kim, Kyeong Seon Min, Eun Seo Park, Gi Ho Park, Hyun Gu Kang, Yeon Shik Choi and Dae Youn Hwang
    Citation: Laboratory Animal Research 2023 39:23
  22. The clinical use of sildenafil citrate (Viagra), a drug used to treat erectile dysfunction, is limited because of its many side effects on tissues. In this context, we aimed to investigate the protective effec...

    Authors: Ibrahim M. Ibrahim Laila, Samar HassabAllah Kassem and Marwa Salah ElDin Mohamed Diab
    Citation: Laboratory Animal Research 2023 39:22
  23. Globally, medicinal plants are used to treat diseases like diabetes. The present study evaluates the possible antioxidant, acute oral toxicity, the in-vitro and in-vivo antidiabetic potential of the hydro-ethanol...

    Authors: Alokali Kiba, Dipankar Saha and Bhrigu Kumar Das
    Citation: Laboratory Animal Research 2023 39:21
  24. Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatric disorders with morphological brain abnormalities. There is a growing body of evidence that abnormalities in the dop...

    Authors: Aysegul Gungor Aydin and Esat Adiguzel
    Citation: Laboratory Animal Research 2023 39:20
  25. Transient receptor potential canonical (TRPC) channels are non-selective cationic channels with permeability to Ca2+ and Na+. Despite their importance, there are currently few studies on TRPC in the periodontal l...

    Authors: Aeryun Kim, Ae Ri Kim, Yeong-Eui Jeon, Yun‑Jung Yoo, Yu-Mi Yang and Eun‑Jung Bak
    Citation: Laboratory Animal Research 2023 39:19
  26. The symbiosis between the Hawaiian bobtail squid Euprymna scolopes and bacterium Vibrio fischeri serves as a model for investigating the molecular mechanisms that promote the initial formation of animal-bacterial...

    Authors: Andrew G. Cecere, Rachel A. Cook and Tim I. Miyashiro
    Citation: Laboratory Animal Research 2023 39:17
  27. Liver fibrosis is an early stage of liver cirrhosis. As a reversible lesion before cirrhosis, liver failure, and liver cancer, it has been a target for drug discovery. Many antifibrotic candidates have shown p...

    Authors: Ji-Hee Hwang, Minyoung Lim, Gyeongjin Han, Heejin Park, Yong-Bum Kim, Jinseok Park, Sang-Yeop Jun, Jaeku Lee and Jae-Woo Cho
    Citation: Laboratory Animal Research 2023 39:16
  28. Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties. Hallucinations, confusion, agitation, aggressiveness, anxiety, and restlessness are reported am...

    Authors: Vincent Onoriode Igben, Wilson Josiah Iju, Omogbiya Adrian Itivere, John Chukwuma Oyem, Peter Sunday Akpulu and Efe Endurance Ahama
    Citation: Laboratory Animal Research 2023 39:15
  29. Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the dev...

    Authors: Emmanuelle Totain, Loïc Lindner, Nicolas Martin, Yolande Misseri, Alexandra Iché, Marie-Christine Birling, Tania Sorg, Yann Herault, Alain Bousquet-Melou, Pascale Bouillé, Christine Duthoit, Guillaume Pavlovic and Severine Boullier
    Citation: Laboratory Animal Research 2023 39:14
  30. Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia administration is an essential step for MCAo, but anestheti...

    Authors: Jinyoung Won, Zeeshan Ahmad Khan and Yonggeun Hong
    Citation: Laboratory Animal Research 2023 39:11
  31. Enrichment of home cages in laboratory experiments offers clear advantages, but has been criticized in some respects. First, there is a lack of definition, which makes methodological uniformity difficult. Seco...

    Authors: Paul Mieske, Julia Scheinpflug, Timur Alexander Yorgan, Laura Brylka, Rupert Palme, Ute Hobbiesiefken, Juliane Preikschat, Lars Lewejohann and Kai Diederich
    Citation: Laboratory Animal Research 2023 39:9
  32. The Omicron variant has become the most prevalent SARS-CoV-2 variant. Omicron is known to induce milder lesions compared to the original Wuhan strain. Fatal infection of the Wuhan strain into the brain has bee...

    Authors: Na Yun Lee, Youn Woo Lee, Seung-Min Hong, Dain On, Gyeong Min Yoon, See-He An, Ki Taek Nam, Jun-Young Seo, Jeon-Soo Shin, Yang-Kyu Choi, Seung Hyun Oh, Jun-Won Yun, Ho Young Lee, Kang-Seuk Choi, Je Kyung Seong and Jun Won Park
    Citation: Laboratory Animal Research 2023 39:8
  33. Hypertension is a medical condition that often comorbidly exist in patients with type II diabetes. Therefore, it is very important to manage both conditions simultaneously to mitigate the complications and mor...

    Authors: Emuesiri Goodies Moke, Eric Kelly Inanemo Omogbai, SammyDavies Ehiosu Osagie-Eweka, Adaeze Phina Uchendu, Odion Martha Obayuwana, Elizabeth Okoro-Akpandu and Benneth Ben-Azu
    Citation: Laboratory Animal Research 2023 39:7
  34. New findings in regenerative medicine have always been combined with numerous animal studies. Therefore, choosing the right translational animal model plays an important role in transferring as much basic know...

    Authors: Kamran Shirbache, Hossein Nematian and Mohammad Hossein Nabian
    Citation: Laboratory Animal Research 2023 39:6
  35. Orthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant immunosuppressive therapy is important to prevent graft failure. We i...

    Authors: Min-Jung Park, Hyun Sik Na, Young-Shin Joo, Keun-Hyung Cho, Se-Young Kim, Jeong Won Choi, Jin-Ah Baek, Jong Young Choi, Young Kyoung You and Mi-La Cho
    Citation: Laboratory Animal Research 2023 39:5
  36. Cudrania tricuspidata is a perennial plant, and Sargassum fusiforme is a brown seaweed with numerous potential benefits, including anticancer, anti-inflammatory, and antioxidant activities. However, the efficacie...

    Authors: Priyanka Rajan, Premkumar Natraj, Nak Hyoung Kim, Jae-Hoon Kim, Hyuk Joon Choi and Chang-Hoon Han
    Citation: Laboratory Animal Research 2023 39:4
  37. Epigallocatechin gallate (EGCG) is a flavonoid compound commonly found in green tea. It exhibits antioxidant, anti-inflammatory, and neuroprotective effects in cerebral ischemia. Protein phosphatase 2 A (PP2A)...

    Authors: Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park and Phil Ok Koh
    Citation: Laboratory Animal Research 2023 39:3
  38. Recombination activating gene2 (Rag2) knockout (KO) mice are used widely in various research fields, including vaccine development, transplantation studies, and hematopoiesis research, but few studies have com...

    Authors: Yu Jeong Roh, Jeong Eun Gong, Ji Eun Kim, You Jeong Jin, Hee Jin Song, Ayun Seol, Jumin Park, Yong Lim and Dae Youn Hwang
    Citation: Laboratory Animal Research 2023 39:2
  39. Disruptions of the intestinal epithelial barrier (IEB) are frequently observed in various digestive diseases, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). This study assessed ...

    Authors: Ji Eun Kim, Hee Jin Song, Yun Ju Choi, You Jeong Jin, Yu Jeong Roh, Ayun Seol, So Hae Park, Ju Min Park, Hyun Gu Kang and Dae Youn Hwang
    Citation: Laboratory Animal Research 2023 39:1
  40. Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals...

    Authors: Siavash Ahmadi-Noorbakhsh, Mohammad Farajli Abbasi, Maedeh Ghasemi, Gholamreza Bayat, Nahid Davoodian, Ehsan Sharif-Paghaleh, Seyedeh Mahsa Poormoosavi, Melika Rafizadeh, Maryam Maleki, Hesamaddin Shirzad-Aski, Hossein Kargar Jahromi, Masoomeh Dadkhah, Bahman Khalvati, Tahereh Safari, Mohammad Amin Behmanesh, Seyed Esmaeil Khoshnam…
    Citation: Laboratory Animal Research 2022 38:40
  41. Fameyes (a mixture of Clematis mandshurica Rupr. extract (CMRE) and Erigeron annuus (L.) Pers. extract (EAPE)) containing scutellarin and chlorogenic acid as major components has been reported to relieve mental s...

    Authors: Junkee Hong, Tae-Kyeong Lee, In Hye Kim, Seungah Lee, Byung-Ju Jeon, Jiwon Lee, Moo-Ho Won and Sungsu Kim
    Citation: Laboratory Animal Research 2022 38:39
  42. Resistance exercise training is known to improve metabolic disorders, such as obesity and type2 diabetes. In this study, we investigated whether the beneficial effects of resistance exercise training persisted...

    Authors: Hye Jin Kim, Youn Ju Kim, Il Yong Kim and Je Kyung Seong
    Citation: Laboratory Animal Research 2022 38:36

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  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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