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  1. TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied ...

    Authors: Chi-Hyun Ahn, Won Woo Lee, Yun Chan Jung, Ji-Ae Shin, Kyoung-Ok Hong, Sujung Choi, Neeti Swarup, Jihoon Kim, Min-Hye Ahn, Minjung Jung, Sung-Dae Cho and Bohwan Jin

    Citation: Laboratory Animal Research 2019 35:27

    Content type: Research

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  2. Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, ha...

    Authors: Yoojin Seo, Su-Jeong Oh, Ji-Su Ahn, Ye Young Shin, Ji Won Yang and Hyung-Sik Kim

    Citation: Laboratory Animal Research 2019 35:26

    Content type: Research

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  3. Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal c...

    Authors: Ju-Bin Kang, Dong-Ju Park and Phil-Ok Koh

    Citation: Laboratory Animal Research 2019 35:24

    Content type: Research

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  4. Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with...

    Authors: Daejin Hyung, Ann-Marie Mallon, Dong Soo Kyung, Soo Young Cho and Je Kyung Seong

    Citation: Laboratory Animal Research 2019 35:23

    Content type: Research

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  5. In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration ...

    Authors: Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, Min Soo Kang, Jong Whi Kim, Kyu Ri Hahn, Dae Young Yoo, Yeo Sung Yoon, In Koo Hwang and Dae Won Kim

    Citation: Laboratory Animal Research 2019 35:21

    Content type: Research

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  6. P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult and aged mice by usi...

    Authors: Tae-Kyeong Lee, Young Eun Park, Cheol Woo Park, Bora Kim, Jae-Chul Lee, Joon Ha Park, Hyang-Ah Lee, Moo-Ho Won and Ji Hyeon Ahn

    Citation: Laboratory Animal Research 2019 35:20

    Content type: Research

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  7. Lipopolysaccharide (LPS) acts as an endotoxin, releases inflammatory cytokines, and promotes an inflammatory response in various tissues. This study investigated whether LPS modulates neuroglia activation and ...

    Authors: Ju-Bin Kang, Dong-Ju Park, Murad-Ali Shah, Myeong-Ok Kim and Phil-Ok Koh

    Citation: Laboratory Animal Research 2019 35:19

    Content type: Research

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  8. Cerebral ischemia is a major cause of neurodegenerative disease. It induces neuronal vulnerability and susceptibility, and leads to neuronal cell death. Resveratrol is a polyphenolic compound that acts as an a...

    Authors: Dong-Ju Park, Ju-Bin Kang, Fawad-Ali Shah and Phil-Ok Koh

    Citation: Laboratory Animal Research 2019 35:18

    Content type: Research

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  9. In our efforts to understand the systemic features of tumors, the importance of animal models is increasing due to the recent growth in the development of immunotherapy and targeted therapies. This has resulte...

    Authors: Mi Ju Kang, Ji Eun Kim, Ji Won Park, Hyeon Jun Choi, Su Ji Bae, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Dae Youn Hwang and Hyun Keun Song

    Citation: Laboratory Animal Research 2019 35:17

    Content type: Research

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  10. Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic...

    Authors: Tae Bin Jeong, Joung-Hee Kim, Sou Hyun Kim, Seunghyun Lee, Seung Won Son, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim, Jae-Hwan Kwak and Young-Suk Jung

    Citation: Laboratory Animal Research 2019 35:16

    Content type: Research

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  11. Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. It is characterized by the accumulation of lipids without alcohol intake and often progresses to non-alcoholic...

    Authors: Seunghyun Lee, Jae-Hwan Kwak, Sou Hyun Kim, Tae Bin Jeong, Seung Won Son, Joung-Hee Kim, Yong Lim, Joon-Yong Cho, Dae Youn Hwang, Kil Soo Kim and Young-Suk Jung

    Citation: Laboratory Animal Research 2019 35:15

    Content type: Research

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  12. A total of 24 SD rats were allotted to four treatment groups such as the control (CON), 1% of cholesterol diet (CHO), 0.5% of coenzyme Q10 (COQ) and 1% of cholesterol plus 0.5% of coenzyme Q10 (CHCQ) groups to de...

    Authors: Ha-Na Kim, Dong-Gyung Jeon, Yong Lim and In-Surk Jang

    Citation: Laboratory Animal Research 2019 35:13

    Content type: Research

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  13. Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion inj...

    Authors: Joon Ha Park, Tae-Kyeong Lee, Dae Won Kim, Cheol Woo Park, Young Eun Park, Bora Kim, Jae-Chul Lee, Hyang-Ah Lee, Moo-Ho Won and Ji Hyeon Ahn

    Citation: Laboratory Animal Research 2019 35:12

    Content type: Research

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  14. Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of three differ...

    Authors: Min-Soo Seo, Young-In Kim, Kyung-Ku Kang, Se-Kyung Oh, Soo-Eun Sung, Young-Suk Jung, Joon Yong Cho, HyunKeun Song, Dae Youn Hwang, Sang-Joon Park and Kil Soo Kim

    Citation: Laboratory Animal Research 2019 35:11

    Content type: Research

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  15. MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is commonly used to induce nigrostriatal defects to induce parkinsonism and/or parkinsonian syndrome, to replicate the lesions seen in Parkinson’s disease (PD...

    Authors: Dong-Joo Hwang, Ki-Chun Kwon, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang and Joon-Yong Cho

    Citation: Laboratory Animal Research 2019 35:10

    Content type: Research

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  16. Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize put...

    Authors: Ji Eun Kim, Young Ju Lee, Sung Ha Ryu, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Yusang Choi, Hyun Gu Kang, Kyu-Bong Kim, Suhkmann Kim, Yong Lim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2019 35:9

    Content type: Research

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  17. Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematol...

    Authors: Bon-Sang Koo, Dong-Ho Lee, Philyong Kang, Kang-Jin Jeong, Sangil Lee, Kijin Kim, Youngjeon Lee, Jae-Won Huh, Young-Hyun Kim, Sang-Je Park, Yeung Bae Jin, Sun-Uk Kim, Ji-Su Kim, Yeonghoon Son and Sang-Rae Lee

    Citation: Laboratory Animal Research 2019 35:7

    Content type: Research

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  18. Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii, which occurs worldwide in mammals and birds. Brain is the primary target organ because Toxoplasma gondii is a ubiquitous intracellular parasit...

    Authors: Hasan Tarik Atmaca, Aycan Nuriye Gazyagci, Osman Safa Terzi, Gungor Cagdas Dincel and Tugce Sumer

    Citation: Laboratory Animal Research 2019 35:6

    Content type: Research

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  19. Streptococcus pneumoniae causes many people to suffer from pneumonia, septicemia, and other diseases worldwide. To identify the difference in susceptibility of and treatment efficacy against S. pneumoniae in thre...

    Authors: Jun-Young Kim, Sun-Min Seo, Han-Kyul Lee, Han-Woong Kim and Yang-Kyu Choi

    Citation: Laboratory Animal Research 2019 35:5

    Content type: Research

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  20. Although Eriobotrya japonica leaves have been studied as a raw material for various cosmetic products, little is known about the anti-oxidant, anti-inflammatory, and anti-melanogenic activities of Eriobotrya japo...

    Authors: Nak-Won Seong, Won-Jun Oh, Il-Soo Kim, Su-Jin Kim, Ji-Eun Seo, Chang-Eon Park, Da-Young Kim, Je-Won Ko and Jong-Choon Kim

    Citation: Laboratory Animal Research 2019 35:4

    Content type: Research

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  21. Iran bears a remarkable variety of reptiles. One of the lizard families occurring in Iran is the Family Agamidae which is widely are distributed throughout the old world. The large-scaled rock agamid, Laudakia nu...

    Authors: Farkhondeh Sayyadi, Nasrullah Rastegar-Pouyani, Mehri Azadbakht and Khosrow Chehri

    Citation: Laboratory Animal Research 2019 35:3

    Content type: Research

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  22. We examined the precision, accuracy, and capability of detecting changes of Dual-Energy X-ray Absorptiometry (DXA) for the measurements of total-body weight (TBW), total-body fat weight (TBFW), and total-body ...

    Authors: Jungyun Yeu, Han-Jik Ko, Doyeun Kim, Youngbok Ahn, Jaejin Kim, Wonhee Lee, IlSin Jung, Jungkyu Suh and Seok-Jong Lee

    Citation: Laboratory Animal Research 2019 35:2

    Content type: Research

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  23. Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed ...

    Authors: Hajin Nam, Yoo Yeon Kim, Boyoung Kim, Won Kee Yoon, Hyoung-Chin Kim and Jun Gyo Suh

    Citation: Laboratory Animal Research 2018 34:3404311

    Content type: OriginalPaper

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  24. CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein α (SIRPα) on macropha...

    Authors: Joo-Il Kim, Jin-Sung Park, Jina Kwak, Hyun-Jin Lim, Soo-Kyung Ryu, Euna Kwon, Kang-Min Han, Ki-Taek Nam, Han-Woong Lee and Byeong-Cheol Kang

    Citation: Laboratory Animal Research 2018 34:3404302

    Content type: OriginalPaper

    Published on:

  25. Nucleotide-binding domain 1 (Nod1) is a cytosolic receptor that is responsible for the recognition of a bacterial peptidoglycan motif containing meso-diaminophimelic acid. In this study, we sought to identify the...

    Authors: Min-Jung Kang, Jin-A Choi, Joo-Hee Choi, Ah-Ra Jang, Ji-Yeon Park, Jae-Hun Ahn, Tae-Sung Lee, Dong-Yeon Kim and Jong-Hwan Park

    Citation: Laboratory Animal Research 2018 34:3404295

    Content type: OriginalPaper

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  26. A few clues about correlation between endoplasmic reticulum (ER) stress and mulberry (Morus alba) leaves were investigated in only the experimental autoimmune myocarditis and streptozotocin-induced diabetes. To i...

    Authors: Mi Rim Lee, Su Ji Bae, Ji Eun Kim, Bo Ram Song, Jun Young Choi, Jin Ju Park, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Young Whan Choi, Kyung Mi Kim and Dae Youn Hwang

    Citation: Laboratory Animal Research 2018 34:3404288

    Content type: OriginalPaper

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  27. This study was conducted to compare the anesthetic effects of 2,2,2-tribromoethanol (TBE, Avertin®) in ICR mice obtained from three different sources. TBE (2.5%) was intraperitoneally injected at three doses: ...

    Authors: Mi Ree Lee, Hye Rin Suh, Myeong Whan Kim, Joon Young Cho, Hyun Keun Song, Young Suk Jung, Dae Youn Hwang and Kil Soo Kim

    Citation: Laboratory Animal Research 2018 34:3404270

    Content type: OriginalPaper

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  28. Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in var...

    Authors: Bo Min Park, Jae-il Roh, Jaehoon Lee and Han-Woong Lee

    Citation: Laboratory Animal Research 2018 34:3404264

    Content type: OriginalPaper

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  29. Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of all human gastric can...

    Authors: Hyejeong Kim, Haengdueng Jeong, Yejin Cho, Jaehoon Lee, Ki Taek Nam and Han-Woong Lee

    Citation: Laboratory Animal Research 2018 34:3404257

    Content type: OriginalPaper

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  30. O-2-18F-fluoroethyl-l-tyrosine ([18F]FET) has been widely used for glioblastomas (GBM) in clinical practice, although evaluation of its applicability in non-clinical research is still lacking. The objective of th...

    Authors: Ok-Sun Kim, Jang Woo Park, Eun Sang Lee, Ran Ji Yoo, Won-Il Kim, Kyo Chul Lee, Jae Hoon Shim and Hye Kyung Chung

    Citation: Laboratory Animal Research 2018 34:3404248

    Content type: OriginalPaper

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  31. Bacopa monnieri is a medicinal plant with a long history of use in Ayurveda, especially in the treatment of poor memory and cognitive deficits. In the present study, we hypothesized that Bacopa monnieri extract (...

    Authors: Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Woosuk Kim, Jong Whi Kim, Dae Young Yoo, Yeo Sung Yoon, In Koo Hwang and Dae Won Kim

    Citation: Laboratory Animal Research 2018 34:3404239

    Content type: OriginalPaper

    Published on:

  32. Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been p...

    Authors: Seunghyun Lee, Jae-Hwan Kwak, Sou Hyun Kim, Jieun Yun, Joon-Yong Cho, Kilsoo Kim, Daeyeon Hwang and Young-Suk Jung

    Citation: Laboratory Animal Research 2018 34:3404232

    Content type: OriginalPaper

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  33. Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative acti...

    Authors: Ji Eun Kim, Mi Ju Kang, Jun Young Choi, Jin Ju Park, Mi Rim Lee, Bo Ram Song, Hye Ryeong Kim, Ji Won Park, Hyeon Jun Choi, Su Ji Bae and Dae Youn Hwang

    Citation: Laboratory Animal Research 2018 34:3404223

    Content type: OriginalPaper

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  34. The efficacy of standard therapeutic strategies for Helicobacter pylori (H. pylori) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investiga...

    Authors: Seong-Soo Hong, Hyun-A Lee, Joo Yun Kim, Ji-Woong Jeong, Jae-Jung Shim, Jung Lyoul Lee, Jae-Hun Sim, Yungho Chung and Okjin Kim

    Citation: Laboratory Animal Research 2018 34:3404216

    Content type: OriginalPaper

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  35. The following experiments were designed to examine the effect of serum of spayed dogs on superovulation response in mice and rats. In Experiment 1, female mice at diestrus (n=30) were divided into three equal ...

    Authors: M. H. Nooranizadeh, A. Mogheiseh, M. Kafi, M. Sepehrimanesh and H. Vaseghi

    Citation: Laboratory Animal Research 2018 34:3404211

    Content type: OriginalPaper

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  36. Hyperglycemia is one of the major risk factors for stroke. Hyperglycemia can lead to a more extensive infarct volume, aggravate neuronal damage after cerebral ischemia. α-Synuclein is especially abundant in ne...

    Authors: Ju-Bin Kang, Dong-Kyun Kim, Dong-Ju Park, Murad-Ali Shah, Myeong-Ok Kim, Eun-Jung Jung, Han-Shin Lee and Phil-Ok Koh

    Citation: Laboratory Animal Research 2018 34:3404195

    Content type: OriginalPaper

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  37. The different polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene promote variances in diabetes susceptibility in humans. We investigated whether these genotypes also promote differences in diabet...

    Authors: Ching-Fu Tu, Chi-Yun Hsu, Meng-Hwan Lee, Bo-Hui Jiang, Shyh-Forng Guo, Chai-Ching Lin and Tien-Shuh Yang

    Citation: Laboratory Animal Research 2018 34:3404185

    Content type: OriginalPaper

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  38. In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in the hippocampus ...

    Authors: Sung Min Nam, Hyun Jung Kwon, Woosuk Kim, Jong Whi Kim, Kyu Ri Hahn, Hyo Young Jung, Dae Won Kim, Dae Young Yoo, Je Kyung Seong, In Koo Hwang and Yeo Sung Yoon

    Citation: Laboratory Animal Research 2018 34:3404176

    Content type: OriginalPaper

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  39. Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunode...

    Authors: Joo-Il Kim, Jin-Sung Park, Hanna Kim, Soo-Kyung Ryu, Jina Kwak, Euna Kwon, Jun-Won Yun, Ki-Taek Nam, Han-Woong Lee and Byeong-Cheol Kang

    Citation: Laboratory Animal Research 2018 34:3404166

    Content type: OriginalPaper

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  40. Breast cancer remains the second leading cause of cancer death among woman, worldwide, despite advances in identifying novel targeted therapies and the development of treating strategies. Classification of cli...

    Authors: Mi Kyung Park, Chang Hoon Lee and Ho Lee

    Citation: Laboratory Animal Research 2018 34:3404160

    Content type: Review

    Published on:

  41. Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used ...

    Authors: Hyeonhui Kim, Minki Kim, Sun-Kyoung Im and Sungsoon Fang

    Citation: Laboratory Animal Research 2018 34:3404147

    Content type: Review

    Published on:

Affiliated with


  • Laboratory Animal Research is the official journal of the Korean Association for Laboratory Animal Science. KALAS was established in 1985 in order to discuss the knowledge of the experiment, and promote the science and technology in laboratory animal sciences.

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