Skip to main content

Advertisement

Table 2 The histological phenotype in the liver of wild and HBx-Tg B6 mice

From: Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

 Group 1Group 2
WTHBx TgP-valueWTHBx TgP-value
Micro-fatty change0/39(0%)3/45(6.7%)0.1019/47(19.1%)40/51(78.4%)0.000
Macro-fatty change0/39(0%)0/45(0%)2/47(4.3%)25/51(49.0%)0.045
Inflammation0/39(0%)10/45(22.2%)0.0029/47(19.1%)5/51(9.8%)0.187
Necrosis0/39(0%)1/45(2.2%)0.3490/47(0%)4/51(7.8%)0.050
Dysplasia0/39(0%)43/45(95.6%)0.0000/47(0%)48/51(94.1%)0.000
Dysplastic nodule0/39(0%)0/45(0%)0/47(0%)1/51(2.0%)0.335
Tumor0/39(0%)0/45(0%)0/47(0%)0/51(0%)
 Group 3Group 4
Micro-fatty change4/13(30.8%)15/15(100%)0.0001/3(33.3%)7/8(87.5%)0.072
Macro-fatty change0/13(0%)15/15(100%)0.0000/3(0%)3/8(37.5%)0.214
Inflammation1/13(7.7%)3/15(20.0%)0.3531/3(33.3%)4/8(50%)0.621
Necrosis1/13(7.7%)1/15(6.7%)0.9160/3(0%)2/8(25.0%)0.338
Dysplasia0/13(0%)15/15(100%)0.0000/3(0%)8/8(100%)0.001
Dysplastic nodule0/13(0%)1/15(6.7%)0.3430/3(0%)5/8(62.5%)0.064
Tumor0/13(0%)1/15(6.7%)0.3430/3(0%)5/8(62.5%)0.064
  1. Group 1: ~ 12 weeks, Group 2: 12~28 weeks
  2. Group 3: 28~44 weeks, Group 4: 44~64 weeks