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Table 2 The histological phenotype in the liver of wild and HBx-Tg B6 mice

From: Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

  Group 1 Group 2
WT HBx Tg P-value WT HBx Tg P-value
Micro-fatty change 0/39(0%) 3/45(6.7%) 0.101 9/47(19.1%) 40/51(78.4%) 0.000
Macro-fatty change 0/39(0%) 0/45(0%) 2/47(4.3%) 25/51(49.0%) 0.045
Inflammation 0/39(0%) 10/45(22.2%) 0.002 9/47(19.1%) 5/51(9.8%) 0.187
Necrosis 0/39(0%) 1/45(2.2%) 0.349 0/47(0%) 4/51(7.8%) 0.050
Dysplasia 0/39(0%) 43/45(95.6%) 0.000 0/47(0%) 48/51(94.1%) 0.000
Dysplastic nodule 0/39(0%) 0/45(0%) 0/47(0%) 1/51(2.0%) 0.335
Tumor 0/39(0%) 0/45(0%) 0/47(0%) 0/51(0%)
  Group 3 Group 4
Micro-fatty change 4/13(30.8%) 15/15(100%) 0.000 1/3(33.3%) 7/8(87.5%) 0.072
Macro-fatty change 0/13(0%) 15/15(100%) 0.000 0/3(0%) 3/8(37.5%) 0.214
Inflammation 1/13(7.7%) 3/15(20.0%) 0.353 1/3(33.3%) 4/8(50%) 0.621
Necrosis 1/13(7.7%) 1/15(6.7%) 0.916 0/3(0%) 2/8(25.0%) 0.338
Dysplasia 0/13(0%) 15/15(100%) 0.000 0/3(0%) 8/8(100%) 0.001
Dysplastic nodule 0/13(0%) 1/15(6.7%) 0.343 0/3(0%) 5/8(62.5%) 0.064
Tumor 0/13(0%) 1/15(6.7%) 0.343 0/3(0%) 5/8(62.5%) 0.064
  1. Group 1: ~ 12 weeks, Group 2: 12~28 weeks
  2. Group 3: 28~44 weeks, Group 4: 44~64 weeks