Skip to main content

Table 2 The histological phenotype in the liver of wild and HBx-Tg B6 mice

From: Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

 

Group 1

Group 2

WT

HBx Tg

P-value

WT

HBx Tg

P-value

Micro-fatty change

0/39(0%)

3/45(6.7%)

0.101

9/47(19.1%)

40/51(78.4%)

0.000

Macro-fatty change

0/39(0%)

0/45(0%)

2/47(4.3%)

25/51(49.0%)

0.045

Inflammation

0/39(0%)

10/45(22.2%)

0.002

9/47(19.1%)

5/51(9.8%)

0.187

Necrosis

0/39(0%)

1/45(2.2%)

0.349

0/47(0%)

4/51(7.8%)

0.050

Dysplasia

0/39(0%)

43/45(95.6%)

0.000

0/47(0%)

48/51(94.1%)

0.000

Dysplastic nodule

0/39(0%)

0/45(0%)

0/47(0%)

1/51(2.0%)

0.335

Tumor

0/39(0%)

0/45(0%)

0/47(0%)

0/51(0%)

 

Group 3

Group 4

Micro-fatty change

4/13(30.8%)

15/15(100%)

0.000

1/3(33.3%)

7/8(87.5%)

0.072

Macro-fatty change

0/13(0%)

15/15(100%)

0.000

0/3(0%)

3/8(37.5%)

0.214

Inflammation

1/13(7.7%)

3/15(20.0%)

0.353

1/3(33.3%)

4/8(50%)

0.621

Necrosis

1/13(7.7%)

1/15(6.7%)

0.916

0/3(0%)

2/8(25.0%)

0.338

Dysplasia

0/13(0%)

15/15(100%)

0.000

0/3(0%)

8/8(100%)

0.001

Dysplastic nodule

0/13(0%)

1/15(6.7%)

0.343

0/3(0%)

5/8(62.5%)

0.064

Tumor

0/13(0%)

1/15(6.7%)

0.343

0/3(0%)

5/8(62.5%)

0.064

  1. Group 1: ~ 12 weeks, Group 2: 12~28 weeks
  2. Group 3: 28~44 weeks, Group 4: 44~64 weeks