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Table 1 Overview of the advantages, disadvantages, and references to promising genetic, neuroimaging, and neuromodulation technologies

From: Rodent models for psychiatric disorders: problems and promises

  Advantages Disadvantages References
Genetics:
 scRNA-seq single cellular resolution Expensive
Large amount of data
Improving bioinformatic pipelines
Kolodziejczyk et al. (2015)
Ofengeim et al. (2017)
Saliba et al. (2014)
 CRISPR/Cas9 Cost and time efficient
Precise editing
Multiple genes simultaneously
Off-target effects
Editing efficiency
Doudna & Charpentier (2014)
Neuroimaging:
 Fiber Photometry Cell-type specific
High temporal resolution
Lack of individual cellular information Dana et al. (2015)
Li et al. (2019)
 1/2-Photon Imaging Cell-type specific
High temporal resolution
High spatial resolution
Larger head mount
Limited free movement
Widely invasive surgery
Leinweber et al. (2014)
Ozbay et al. (2018)
Neuromodulation:
 Optogenetics Cell-type specific
High temporal specificity
Capability of fine temporal manipulation
Difficulty targeting deeper structures
Implanted fiber cable
Boyden et al. (2005)
Govorunova et al. (2015)
 Chemogenetics Cell-type specific
Free moving behavior
Higher penetrance
Long duration effect
Potential off target effects of ligand
Relative low temporal specificity
Armbruster et al. (2007)
Magnus et al. (2019)