Fig. 2

Repeated RST-induced anxiety- and depressive-like behaviors in mice derived from three different sources. (a, b) Immobility time in FST and TST, and c, d, and e The time spent in the center and periphery zones, entries in the center, and the number of line crossings in the zone analysis of OFT following exposure to repeated restraint stress. Data are presented as the mean ± SEM; n = 10 mice per group. *Denotes statistical difference from the control mice (*p < 0.05; **p < 0.01; ***p < 0.001). RST, restraint stress, FST, forced swim test; TST, tail suspension test; OFT, open field test; SEM, mean ± standard error