Fig. 3
From: Zebrafish toxicological screening could aid Leishmaniosis drug discovery
Example of cardiographs, representing the time series of patterns of intensity (green channel from RGB) of the horizontal and vertical lines (1000 digitized frames), positioned on center of the heart´s larvae. Based on the image pattern formed, the rate and the rhythm of the heartbeat were calculated. In image (A), the constant rhythm of the heartbeat of a larva exposed to 12.5 µM of 2-aminobenzimidazole-derived can be observed, and in image (B) an altered rhythm of the positive control heartbeat of an exposed larva at 10.0 µM haloperidol (beat heating rate = 150 bpm, sample entropy = 1.05 and Poincaré: S = 3267) is showed. In this case, it is possible to observe variable time intervals of cardiac contractions (beat heating rate = 186 bpm, sample entropy = 0.11 and Poincaré: S = 8.28)