Fig. 1From: Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 miceTrp53 gene deletion. After the design and synthesis of two highly active TALENs specific to exon 2 of Trp53, each TALEN mRNA was injected into the cytoplasm of mouse pronuclear-stage embryos to produce FVB/N-Trp53em2Hwl/Korl (A) and C57BL/6-Trp53em1Hwl/Korl (B) KO mice deficient in p53Back to article page