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Fig. 1 | Laboratory Animal Research

Fig. 1

From: Therapeutic effect of intra-articular injected 3′-sialyllactose on a minipig model of rheumatoid arthritis induced by collagen

Fig. 1

Effects of 3′-SL administration on clinical symptoms of a minipig model of rheumatoid arthritis induced by intra-articular injection of heterologous CII emulsified with CFA or IFA. A Experimental procedure for evaluating the therapeutic effect of 3′-SL in the rheumatoid arthritis minipig model. B Representative images of knee joints of rheumatoid arthritis-induced minipigs. Arrow head indicates swelling near the knee joint. Dotted arrow indicates the region where the width of the knee joint is measured. R: right knee joint; L: left knee joint. C Relative width difference of the knee joint. The difference in the width of the knee joint was calculated by subtracting the right knee value from the left knee value. These values were normalized to the length of D0. Error bars represent SD. D Representative C-arm images of the knee joint of a minipig model of rheumatoid arthritis. VC: vehicle control; G1: 2 mg/kg treatment group; G2: 10 mg/kg treatment group; G3: 50 mg/kg treatment group

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Laboratory Animal Research

ISSN: 2233-7660