Table 4 Effects of losartan, metformin and glibenclamide on systolic blood pressure of DOCA + STZ hypertensive diabetic rats

Normal Control

89.67 ± 0.33

88.67 ± 2.73

89.33 ± 3.84

96.33 ± 7.33

97.33 ± 2.85

100.33 ± 2.73

HD Control

90.33 ± 3.18

127.67 ± 1.45^*

134.33 ± 0.88^*

147.67 ± 4.33^*

147.67 ± 5.04^*

146.67 ± 3.48^*

HD + LOS + MET

93.33 ± 0.33

118.33 ± 1.76^*#

126.67 ± 3.53^*

130.67 ± 0.33^*

120.67 ± 6.39^#

115.67 ± 4.91^#

HD + LOS + GLB

96.33 ± 0.33

118.67 ± 0.33^*#

121.67 ± 1.20^*#

128.33 ± 2.03^*#

119.33 ± 6.36^#

121.67 ± 2.03^*#

HD + LOS + MET + GLB

95.00 ± 8.14

116.67 ± 1.76^*#

118.33 ± 2.33^*#

123.33 ± 0.88^*#

111.33 ± 5.93^#

112.00 ± 4.93^#