Table 1 Reports of S. xylosus skin infection in mice

Forkhead box N1 (Foxn1) knockout (nude mice)

Lack of T cells and aberrant skin differentiation

[88, 89]

Neutrophil cytosolic factor 1 (Ncf1 or gp47^phox) knockout

Deficient NADPH oxidase activity and impaired neutrophil function

[71,72,73]

Integrin beta 2 (Itgb2 or CD18) knockout

Defective neutrophil and T cell activity

[78]

Nitric oxide synthase 2 (Nos2) knockout

Deficient production of reactive nitrogen species, impaired neutrophil recruitment and delayed wound closure and increased Th1 responses

[76, 77]

Exogenous infection of SJL/J

No specific defect

[111]

C57BL/6 and a variety of knockouts on C57BL/6 background

No specific defect

Defective production of IL-2, IL-4, IL05, IL-10, and/or IL-12

Defective complement

Defective NK cell mediated antibody dependent cytotoxicity and phagocytosis

Defective mast cell responses

[76]

Cytochrome b-245 beta chain (Cybb or gp91^phox) knockout

Deficient NADPH oxidase activity and impaired neutrophil function

[71]

Stearoyl CoA desaturase 1 (SCD1) knockout

Aberrant skin differentiation

[36]

Replication timing regulatory factor 1 (Rif1) knockout

Impaired class-switch recombination of immunoglobulins

[92]

Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta (Nfkbiz or IκBζ) knockout

Elevated serum IgE and increased numbers of IL-17A-secreting CD4+ T cells in skin

[69]

Recombination activating 1 (Rag1) and mitogen-activated protein kinase kinase kinase 8 (Map3k8 or Tpl2) double knockout

Lack of B cells and T cells and defects in superoxide production by macrophages

[87]

Leptin receptor (Lepr or db) knockout

Diabetic with chronic wound

[96]

Oxazolone induced atopic dermatitis lesions in C57BL/6J

Mixed Th1-Th2-mediated allergic response

[67]