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Table 1 Body weight, body condition score (BCS), and clinical features of dogs

From: Regular medical checkup program (in K-MEDI hub) to enhance the welfare of laboratory dogs and pigs

Animal number

1H 2019

2H 2019

1H 2020

Body weight (kg)

Body temperature (°C)

BCS

Clinical feature

Body weight (kg)

Body temperature (°C)

BCS

Clinical feature

Body weight (kg)

Body temperature (°C)

BCS

Dog-#1

12.1

37.8

5

ND

13.8

10.9

3

Feed amount 200 g → 300 g 2

12.3

38.9

4

Dog-#2

8.5

38.5

5

ND

9.2

38.1

5

ND

9.65

39

4.5

Dog-#3

8.35

38.5

5

ND

Euthanized

Dog-#4

11.4

38.7

5

ND

Euthanized

Dog-#5

7.75

39.3

4

ND

Euthanized

Dog-#6

7.15

39.3

4

ND

Euthanized

Dog-#7

8.65

38.8

5

ND

Euthanized

Dog-#8

9.1

39

5

ND

Euthanized

Dog-#9

8.95

38.6

4

ND

Euthanized

Dog-#10

9.45

39.3

6

ND

9.42

38.9

3

ND

10.9

38.8

4

Dog-#11

9.3

37.4

4

ND

Euthanized

Dog-#12

9.65

38.1

5

ND

Euthanized

Dog-#13

10.5

38.2

5

ND

Euthanized

Dog-#14

10.05

38.8

5

ND

Euthanized

Dog-#15

10.5

37.6

4

ND

9.7

38.2

3

Monocytosis3

13.55

38.9

5

Dog-#16

10.45

38.3

5

ND

10.9

38.5

4

Mild labored breathing4,

neutrophilia 5

12

39.6

4

Dog-#17

9.8

38.1

5

ND

10.9

38.1

4

ND

10.8

39.2

4

Dog-#18

10.55

39

5

ND

12.6

38

5

ND

13.15

39.2

5

Dog-#19

10.9

38.8

5

ND

12.45

37.8

5

ND

12.45

38.6

4

Dog-#20

13.8

37.6

5

ND

Euthanized

Dog-#21

11.45

38.7

5

ND

13.8

39.3

5

ND

12.6

40.2

5

Dog-#22

11.05

38.7

5

ND

11.5

38.8

3

Feed amount 200 g → 300 g

12.9

39

4

Dog-#23

9.5

38.6

5

ND

10.2

39.1

5

ND

Euthanized

Dog-#24

11.45

38.4

6

ND

12.75

39.5

3

ND

13

39.6

5

Dog-#25

10.35

38.5

5

ND

10.9

41.1

5

Mild labored breathing4

12.3

40

5

Dog-#26

10.15

38.6

6

ND

12.9

38.6

4

ND

Euthanized

Dog-#27

7.65

39

4

ND

Euthanized

Dog-#28

10

38.5

5

ND

12.8

38.4

6

Feed amount 300 g → 200 g

13.05

39.1

4

Dog-#29

7.5

38.6

3

Feed amount: 150 g → 200 g

Euthanized

Dog-#30

10.05

38.3

5

ND

11.9

38.1

5

Mild labored breathing4

12.2

39.5

5

Dog-#31

6.3

39.3

4

ND

Euthanized

Dog-#32

8.65

38.6

5

ND

10.7

38.7

5

ND

10.5

38.9

4

Dog-#33

9.45

37.6

5

ND

11.3

38.9

4

ND

 

Dog-#34

8.6

39.3

5

ND

Euthanized

Dog-#35

6.6

39.3

4

ND

Euthanized

Dog-#36

10.2

38

4

ND

10.6

38.5

6

ND

11.3

39.1

5

Dog-#37

8.85

38.4

6

ND

11.5

38.8

4

ND

11.25

39.1

5

Dog-#38

9.45

37.6

4

ND

11.1

38.5

5

The right hind leg lameness

Monocytosis5

Euthanized

Dog-#39

6.45

38.8

3

Retained deciduous teeth of right upper canine, bleeding1

Euthanized by humane endpoint

Dog-#40

6.35

37.1

4

ND

Euthanized

Dog-#41

7.5

38.3

4

ND

Euthanized

Dog-#42

7.55

37.6

4

ND

Euthanized

Dog-#43

8.7

38.6

4

ND

10.55

38.5

5

Neutrophila6

Euthanized

Dog-#44

8.9

37.6

4

ND

Euthanized

Dog-#45

9.5

38.8

5

ND

Euthanized

Dog-#46

Before bringing in animals

12.25

39.1

5

ND

Euthanized

Dog-#47

12.5

39.1

5

ND

9.7

39

5

Dog-#48

Before bringing in animals

9.1

38.9

4.5

  1. ND: Not detected; Euthanized: Euthanized due to study termination; BCS: Body condition score. Superscript numbers indicate the actions taken, as follows:
  2. 1Difficulty in feeding due to right upper deciduous canine tooth with bleeding gums → euthanizing with early termination of experiments to alleviate pain, considering animal welfare
  3. 2BCS was 3/9 → feed for dog-#29 increased from 150 g/day to 200 g/day. The BCS of the dog was 4/9 at medical checkup during the second half.
  4. 3Monocytosis after a bronchial transplant experiment, detected 2 weeks before examination → antibiotics treatment (enrofloxacin 5 mg/kg once daily (SID) for 3 days). Blood re-analysis after 3 weeks—The monocyte concentration in blood decreased to 1.81 × 103 cells/uL
  5. 4Mild labored breathing 2 weeks after bronchial transplant experiment → breathing of the dogs normalized after 3 weeks and maintained during a medical examination in 1H 2020
  6. 5Lameness of the right hind leg was found in dog-#16 with monocyte after the right hind leg implant experiment 1 week before the medical checkup → antibiotics treatment (enrofloxacin 5 mg/kg SID for 3 days). Blood re-analysis in 3 weeks—Monocyte normalized to 0.83 × 103 cells/uL, the dog did not show lameness after 3 weeks
  7. 6neutrophilia after bronchial transplant experiments → antibiotics treatment (enrofloxacin 5 mg/kg SID for 3 days). Blood re-analysis after 3 weeks—Neutrophil count normalized to 6.50 × 103 cells/uL