Fig. 2
From: Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea
Effect of shikimic acid on p53 gene in the kidney of normal and diarrheal rats. A Immuno-histochemically stained kidney tissue reveals tumor suppressive gene p53 expression in the control group, showing a normal amount of expressed tumor suppressive gene p53. B. Kidney tissue of diarrheal rats reveals a decrease in p53 expression, which appeared as weak immune-staining tissue. C. An increase in expression of tumor suppressive gene p53 in the kidney of diarrheal rats treated with desmopressin drug appeared in the positive staining kidney tissue. D. The expression of the tumor suppressive gene p53 was increased in diarrheal rats after oral administration of shikimic acid, where a positive staining of kidney tissue was observed