Fig. 4
From: Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea
Effect of shikimic acid on kidney tissue in normal and diarrheal groups. A photomicrograph of rat kidney (H&E) from: (A, 200) The control group reveals normal kidney construction; (B, 200) and (C, 400) the diarrheal group treated with shikimic acid exhibits widespread coagulative necrosis (B, black arrows) with dilatation, vacuolar degeneration, epithelial desquamation, and intraluminal cast formation (C, white arrows) in the proximal tubules; (D, 200) The diarrheal group after oral administration with shikimic acid shows an obvious improvement in the histological construction and looks like the control group