Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea

Table 2 Effect of shikimic acid on kidney function, electrolytes, and weight in normal and diarrheal rats

Groups	Serum electrolytes levels		Serum urea and creatinine levels		Kidney weight (g/100 g bwt)	Serum chloride (mmol/L)
Groups	Sodium (mmol/L)	Potassium (mmol/L)	Urea (mg/dL)	Creatinine (mg/dL)	Kidney weight (g/100 g bwt)	Serum chloride (mmol/L)
Control	152.32 ± 4.64	5.58 ± 0.26	24.81 ± 2.71	0.82 ± 0.07	0.69 ± 0.05	104.29 ± 2.35
Shikimic acid	150.46 ± 3.85	5.56 ± 0.31	24.75 ± 2.39	0.81 ± 0.05	0.70 ± 0.07	102.87 ± 2.46
Desmopressin drug	151.71 ± 4.53	5.59 ± 0.27	24.84 ± 2.80	0.80 ± 0.06	0.67 ± 0.09	105.12 ± 2.18
Diarrheal rats	98.76 ± 4.03^b	2.52 ± 0.34^b	41.20 ± 2.67^b	1.43 ± 0.05^b	0.48 ± 0.03^b	79.61 ± 1.65^b
Diarrheal rats + Shikimic acid	145.8 ± 3.75^c	5.19 ± 0.24^c	29.74 ± 2.65^c	0.79 ± 0.06^d	0.67 ± 0.07^d	98..50 ± 2.41^c
Diarrheal rats + Desmopressin drug	151.24 ± 3.50^d	5.49 ± 0.32^d	25.26 ± 3.59^d	0.81 ± 0.04^d	0.71 ± 0.06^d	101.54 ± 1.86^d

Number of animals = 6 rats/group. Results were expressed as mean ± SEM. Statistical analysis was one-way ANOVA test
^aP ≤ 0.05 significant change compared to control group
^bP ≤ 0.01 highly significant change compared to control group
^cP ≤ 0.05 significant change compared to diarrheal group
^dP ≤ 0.01 highly significant change compared to diarrheal group

ISSN: 2233-7660