Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea

Table 3 Effect of shikimic acid on urinary volume and electrolyte excretion in normal and diarrheal rats

Group	Urinary volume (mL/100 g/8 h)	Diuretic index	Urinary Sod. (mmol/L)	Urinary Pot. (mmol/L)	Saluretic index		Urinary Sod./Pot	Urinary Chlor
Group	Urinary volume (mL/100 g/8 h)	Diuretic index	Urinary Sod. (mmol/L)	Urinary Pot. (mmol/L)	Sod.	Pot	Urinary Sod./Pot	Urinary Chlor
Control	0.96 ± 0.19	–	98.52 ± 6.28	56.14 ± 2.90	–	–	1.75	7.61 ± 0.45
Shikimic acid	0.94 ± 0.23	–	96.94 ± 5.73	55.68 ± 2.83	–	–	1.74	7.59 ± 0.58
Desmopressin drug	0.97 ± 0.18	–	97.64 ± 5.48	57.14 ± 2.69	–	–	1.70	7.60 ± 0.39
Diarrheal rats	1.30 ± 0.41^b	1.35	130.41 ± 7.20^b	75.65 ± 3.12^b	1.32	1.35	1.72	5.28 ± 0.27^b
Diarrheal rats + shikimic acid	1.04 ± 0.20^c	1.08	103.74 ± 5.39^c	60.13 ± 2.79^d	1.05	1.07	1.73	6.87 ± 0.59^c
Diarrheal rats + desmopressin drug	1.01 ± 0.36^c	1.05	101.26 ± 4.80^d	59.07 ± 2.24^d	1.03	1.05	1.71	6.98 ± 0.43^c

Number of animals = 6 rats/group. Results were expressed as mean ± SEM. Statistical analysis was one-way ANOVA test
^aP ≤ 0.05 significant change compared to control group
^bP ≤ 0.01 highly significant change compared to control group
^cP ≤ 0.05 significant change compared to diarrheal group
^dP ≤ 0.01 highly significant change compared to diarrheal group. Diuretic index: Urine volume of treated group/Urine volume of the control group. Saluretic Sodium/Potassium index: Urinary Sodium/Potassium of treated group/Urinary Sodium/Potassium of the control group. Sod.: Sodium. Pot.: Potassium. Chor.: Chloride

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