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Table 4 Effect of shikimic acid on antioxidants levels in the kidney of normal and diarrheal rats

From: Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea

Parameters

Control

Shikimic acid

Desmopressin drug

diarrheal rats

diarrheal rats + shikimic acid

diarrheal rats + desmopressin

Superoxide dismutase

(U/g tissue)

3250 ± 60

3240 ± 50

3245 ± 55

1170 ± 40b

3230 ± 50d

3220 ± 70d

Glutathione peroxidase

(U/g tissue)

785 ± 19

780 ± 24

785 ± 21

365 ± 18b

775 ± 16d

770 ± 21d

Catalase (µmol H2O2/ min/mg tissue)

0.18 ± 0.05

0.19 ± 0.04

0.17 ± 0.06

0.09 ± 0.03b

0.14 ± 0.06c

0.15 ± 0.05c

Malondialdehyde

(µmol/g tissue)

8.52 ± 0.60

8.49 ± 0.72

8.50 ± 0.69

19.38 ± 0.54b

9.54 ± 0.83d

9.58 ± 0.90d

NADPH oxidase activity (mg/mg protein × 105)

12.3 ± 1.18

12.5 ± 1.54

12.4 ± 1.37

8.6 ± 1.31a

10.5 ± 1.25c

10.7 ± 1.26c

Conjugated dienes

(μmol/g tissue)

1.45 ± 0.19

1.42 ± 0.17

1.43 ± 0.15

1.86 ± 0.24a

1.64 ± 0.19c

1.62 ± 0.17c

Oxidative index

(A233/A215 ratio)

0.49 ± 0.03

0.47 ± 0.05

0.50 ± 0.03

0.62 ± 0.04a

0.54 ± 0.05c

0.52 ± 0.06c

  1. Number of animals = 6 rats/group. Results were expressed as mean ± SEM. Statistical analysis was one-way ANOVA test
  2. aP ≤ 0.05 significant change compared to control group
  3. bP ≤ 0.01 highly significant change compared to control group
  4. cP ≤ 0.05 significant change compared to diarrheal group
  5. dP ≤ 0.01 highly significant change compared to diarrheal group