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Table 5 Effect of shikimic acid on inflammatory markers in the kidney of normal and diarrheal rats

From: Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea

Parameters

Control

Shikimic acid

Desmopressin drug

diarrheal rats

diarrheal rats + shikimic acid

diarrheal rats + desmopressin drug

Tumor necrosis factor-α (ng/g tissue)

46.8 ± 2.71

45.9 ± 2.68

47.3 ± 2.59

65.2 ± 2.59a

45.3 ± 2.64d

45.6 ± 2.48d

Interleukin-1β

(ng/g tissue)

6.5 ± 0.4

6.4 ± 0.7

6.6 ± 0.5

8.6 ± 0.3a

8.4 ± 0.6c

8.7 ± 0.5c

Interleukin-6

(pg/g tissue)

54.6 ± 5.7

55.2 ± 6.1

53.8 ± 4.9

107 ± 4.5b

56.1 ± 7.2d

57.0 ± 6.3d

Interleukin-10

(pg/g tissue)

36.4 ± 3.9

34.8 ± 3.7

35.7 ± 4.0

24.5 ± 2.3a

33.8 ± 3.6c

32.9 ± 4.1c

  1. Number of animals = 6 rats/group. Results were expressed as mean ± SEM. Statistical analysis was one-way ANOVA test
  2. aP ≤ 0.05 significant change compared to control group
  3. bP ≤ 0.01 highly significant change compared to control group
  4. cP ≤ 0.05 significant change compared to diarrheal group
  5. dP ≤ 0.01 highly significant change compared to diarrheal group
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Laboratory Animal Research

ISSN: 2233-7660