Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans

Table 3 Auditory system age equivalence in humans and animals

Events/species	Cochlear hair cell differentiation	ABR onset^a	ABR latency maturation^b	ABR threshold maturation^c	ARHL onset	Reference
Human	GD 74, 26% of gestation	GD 175, 63% of gestation	16 M	2 Y	60–69 Y^d	Hecox and Galambos [78]
						Starr et al. [76]
						Sasama [82]
						Pujol et al. [73]
						Bainbridge and Wallhagen [83]
Sheep	NA	GD 106, 72% of gestation	49 D	NA	NA	Wolfson et al. [77]
Sheep	NA	GD 106, 72% of gestation	49 D	NA	NA	Griffiths et al. [81]
Rat	GD 20, 91% of gestation	12.5 D	56 D	22 D	12—over 30 M^e	Church et al. [79]
						Geal-Dor et al. [84]
						Zine and Romand [74]
						Popelar et al. [85]
						Qiu et al. [86]
Mice	GD 15.5, 78% of gestation	12 D	30 D	14 D	3—over 24 M^e	Song et al. [80]
						Sha et al. [87]
						Chonko et al. [75]
						Keithley et al. [88]

ABR: Auditory brainstem response; ARHL: age-related hearing loss; D: days after birth; GD: gestational days; M: months after birth; NA: not available; Y: years after birth
^aDefined by the earliest time point that the ABR potential can be recorded
^bDefined by the earliest time point that the adult-like ABR latency can be recorded
^cDefined by the earliest time point that the adult-like ABR threshold pattern can be recorded
^dDefined by the prevalence of AHRL excess 30% in the studied population
^eDepending on the strains

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