Fig. 3
From: Insight into the emerging and common experimental in-vivo models of Alzheimer’s disease
Transgenic and emerging models of AD. There are various knock-in and knock-out models of AD which overexpress certain genes related to AD pathology. Models like PDAPP, APP23, Tg2576 and hAPP-J20 overexpress APP gene to produce increased amount of Aβ along with other pathologies. P301S model exhibits increased tau hyperphosphorylation and models including APP/PS1, 3 × Tg and 5 × FAD show various pathologies altogether comprising Aβ deposition, tau hyperphosphorylation, neuroinflammation and other pathologies. Further figure shows newly discovered models which mimic the AD associated pathologies resulting in the development of reliable model for studying the pathogenesis and therapeutics for AD. These models include oAβ25-35 model, transgenic model expressing 82-kDa ChAT, oDGal mouse and APP knock-in rat