Insight into the emerging and common experimental in-vivo models of Alzheimer’s disease

Table 3 Timeline for the emergence of pathophysiological and behavioral hallmarks in various animal models of AD

S.No.	Animal model	Timeline for Pathophysiological alterations	Timeline for behavioral alterations	References
1.	Streptozotocin	21 days	15 days	[20, 21, 136, 137]
2.	Scopolamine	13 days	9 days	[35, 36]
3.	Colchicine	2 weeks	21 days	[138, 139]
4.	Okadaic acid	13 days	10 days	[140, 141]
5.	Amyloid-β1-42	15 days	14 days	[142, 143]
6.	Acrolein	12 weeks	4 weeks	[144, 145]
7.	Heavy metals	25 days	21 days	[146, 147]
8.	PDAPP	6–9 months	3–4 months	[148, 149]
9.	APP23	6 months	3 months	[150, 151]
10.	Tg2576	3 months	9–10 months	[88, 148]
11.	hAPP-J20	5–6 months	9–12 months	[96, 97]
12.	P301S mice	6 months	9–12 months	[101]
13.	APP/PS1	2–3 months	120–250 days	[148]
14.	3 × Tg	6–12 months	4 months	[108, 109]
15.	5 × FAD	2 months old	4–5 months	[152]

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