Fig. 3
Histology of the Testes; Stain H and E; × 100. Lumen of seminiferous tubule (black star), basement membrane (red arrow), interstitial space (blue star), spermatogenic cells (yellow spanned arrow). The testicular histoarchitecture in the control group (A) showed a round-oval-shaped seminiferous tubule with an intact basement membrane containing proliferating spermatogenic cells; there is also the presence of testosterone-secreting Leydig cells within the interstitial spaces separating the seminiferous tubules. Diabetic animals (B) showed disrupted testicular morphology, abnormal shape of the seminiferous tubule with thin basement membrane, degeneration of appreciable sum of spermatogenic cells, presence of few or no Leydig cells within the interstitial spaces, and reduced spermatogenesis rate. Diabetic + naringin (C) showed a slightly improved morphology of the seminiferous tubule and spermatogenesis rate. DM + OPE (D) and DM + Met (E) showed oval seminiferous tubules with improved proliferation of spermatogenic cells