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Table 5 Effect of naringin on oxidative stress and inflammatory markers

From: Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance

 

CTRL

DMU

DM + naringin

DM + OPE

DM + Met

MDA (µM)

1.59 ± 0.10

8.98 ± 0.18a

5.26 ± 0.16a,b

3.56 ± 0.15a,b,c

2.69 ± 1.70a,b,c,d

SOD (U/mg)

4.25 ± 0.16

1.13 ± 0.10a

2.32 ± 0.12a,b

3.21 ± 0.18a,b,c

3.11 ± 0.13a,b,c,

Catalase (U/mg)

15.94 ± 0.28

7.38 ± 0.27a

10.78 ± 0.39a,b

12.26 ± 0.31a,b,c

11.98 ± 0.41a,b,c

TAC(mmol/g tissue)

1.08 ± 0.03

0.15 ± 0.08a

0.79 ± 0.05a,b

0.91 ± 0.04a,b,c

0.93 ± 0.06a,b,c

TnF-a (pg/mL)

5.57 ± 0.13

10.89 ± 0.23a

7.98 ± 0.32a,b

6.42 ± 0.32 a,b,c

6.51 ± 0.36a,b,c

CRP (ng/ml)

0.14 ± 0.01

0.63 ± 0.06a

0.48 ± 0.02a,b

0.27 ± 0.01a,b,c

0.25 ± 0.02a,b,c

  1. Data were analyzed by one way ANOVA (and expressed as mean ± SEM) followed Tukey’s posthoc test. DMU: Diabetic untreated, DM + naringin: Diabetic treated with naringin; DM + OPE: Diabetic treated with orange peel extract; DM + met: Diabetic, treated with metformin
  2. aP < 0.05 vs control
  3. bP < 0.05 vs DMU
  4. cP < 0.05 vs DM + naringin
  5. dP < 0.05 vs DM + OPE